Results 101 to 110 of about 42,458 (304)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Neutronics analysis of spin-polarized fuel in spherical tokamaks

Nuclear Fusion
The effect of spin-polarized deuterium–tritium fuel on the blanket, magnets, and surrounding structures is analyzed for a spherical tokamak fusion power plant.
Jin Whan Bae, Katarzyna Borowiec, Vittorio Badalassi, Jason Parisi, Ahmed Diallo, Jon Menard, Andrei Khodak, Thomas Brown   +7 more
doaj   +1 more source

Neutronic investigation of waste transmutation option without partitioning and transmutation in a fusion-fission hybrid system

Nuclear Engineering and Technology, 2018
A feasibility of reusing option of spent nuclear fuel in a fusion-fission hybrid system without partitioning was checked as an alternative option of pyro-processing with critical reactor system. Neutronic study was performed with MCNP 6.1 for this option,
Seong Hee Hong, Myung Hyun Kim
doaj   +1 more source

Interplanetary propulsion using inertial fusion [PDF]

, 1987
Inertial fusion can be used to power spacecraft within the solar system and beyond. Such spacecraft have the potential for short-duration manned-mission performance exceeding other technologies.
Diaz, F. C., Hoffman, N., Hogan, W. J., Klein, G., Murray, K., Orth, C. D.   +5 more
core   +1 more source

Development of Fusion Reactor Blanket System.

Journal of Plasma and Fusion Research, 1999
In a fusion reactor, the blanket performs the important functions of tritium breeding, heat production, and shielding. System integration must be considered in the blanket’s development and design. This report stresses the importance of system integration and describes recent developments in the materials of the blanket system as well as relevant ...
openaire   +2 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Fusion technologies for Laser Inertial Fusion Energy (LIFE)∗

EPJ Web of Conferences, 2013
The Laser Inertial Fusion-based Energy (LIFE) engine design builds upon on going progress at the National Ignition Facility (NIF) and offers a near-term pathway to commercial fusion.
Kramer K.J., Latkowski J.F., Abbott R.P., Anklam T.P., Dunne A.M., El-Dasher B.S., Flowers D.L., Fluss M.J., Lafuente A., Loosmore G.A., Morris K.R., Moses E., Reyes S.   +12 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source