Results 101 to 110 of about 42,805 (305)

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Neutronics analysis of spin-polarized fuel in spherical tokamaks

Nuclear Fusion
The effect of spin-polarized deuterium–tritium fuel on the blanket, magnets, and surrounding structures is analyzed for a spherical tokamak fusion power plant.
Jin Whan Bae, Katarzyna Borowiec, Vittorio Badalassi, Jason Parisi, Ahmed Diallo, Jon Menard, Andrei Khodak, Thomas Brown   +7 more
doaj   +1 more source

Neutronic investigation of waste transmutation option without partitioning and transmutation in a fusion-fission hybrid system

Nuclear Engineering and Technology, 2018
A feasibility of reusing option of spent nuclear fuel in a fusion-fission hybrid system without partitioning was checked as an alternative option of pyro-processing with critical reactor system. Neutronic study was performed with MCNP 6.1 for this option,
Seong Hee Hong, Myung Hyun Kim
doaj   +1 more source

Development of Fusion Reactor Blanket System.

Journal of Plasma and Fusion Research, 1999
In a fusion reactor, the blanket performs the important functions of tritium breeding, heat production, and shielding. System integration must be considered in the blanket’s development and design. This report stresses the importance of system integration and describes recent developments in the materials of the blanket system as well as relevant ...
openaire   +2 more sources

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Fusion technologies for Laser Inertial Fusion Energy (LIFE)∗

EPJ Web of Conferences, 2013
The Laser Inertial Fusion-based Energy (LIFE) engine design builds upon on going progress at the National Ignition Facility (NIF) and offers a near-term pathway to commercial fusion.
Kramer K.J., Latkowski J.F., Abbott R.P., Anklam T.P., Dunne A.M., El-Dasher B.S., Flowers D.L., Fluss M.J., Lafuente A., Loosmore G.A., Morris K.R., Moses E., Reyes S.   +12 more
doaj   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Interplanetary propulsion using inertial fusion [PDF]

, 1987
Inertial fusion can be used to power spacecraft within the solar system and beyond. Such spacecraft have the potential for short-duration manned-mission performance exceeding other technologies.
Diaz, F. C., Hoffman, N., Hogan, W. J., Klein, G., Murray, K., Orth, C. D.   +5 more
core   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Impact of high-fidelity temperature feedback modeling on fusion blanket neutronics

Nuclear Fusion
Accurate modeling and simulation of neutron and gamma transport and interactions within fusion tokamaks represents a critical area of research for fusion energy development.
Jin Whan Bae, Arpan Sircar, Katarzyna Borowiec, Vittorio Badalassi, Cami Collins   +4 more
doaj   +1 more source