Results 121 to 130 of about 928,726 (300)

Computational Mechanism Design for Information Fusion within Sensor Networks

, 2006
Conventional centralised information fusion and control architectures will be challenged by developments in sensor networks that allow sophisticated autonomous sensors, owned by different stakeholders with individual goals, to interact and share ...
S. Reece, N. Jennings, Dash, Rajdeep K, Rogers, Alex, Dash, RK, S. Roberts, Roberts, Stephen, Jennings, N. R., Roberts, S, Rogers, A, Reece, Steve, R. Dash, A. Rogers, Dash, Rajdeep K., Jennings, NR, Reece, S, IEEE   +16 more
core   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Non uniform thickness neutron spectrum shifter to fit radiation BB effects on material in IFMIF-DONES

Nuclear Engineering and Technology
The International Fusion Materials Irradiation Facility – Demo Oriented Neutron Source (IFMIF-DONES) plays an essential role in testing and qualifying materials for the development of nuclear fusion technology.
F. Mota, M.I. Ortiz, F. Arranz, B. Brañas, D. Rapisarda   +4 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Integral analysis of the effect of material dimension and composition on tokamak neutronics

Nuclear Fusion
The neutronics performance of a tokamak has been identified as an important factor in designing a fusion power plant. The design of the tokamak should not only meet operational parameters such as sufficient tritium breeding, but also safety parameters ...
Jin Whan Bae, Davin Young, Katarzyna Borowiec, Vittorio Badalassi   +3 more
doaj   +1 more source

RFP based fusion-fission hybrid reactor model for nuclear applications

, 2019
The Reversed Field Pinch (RFP) configuration looks to be an attractive option for fusion-fission hybrid reactors: the toroidal magnetic systems would be made of copper coils instead of more expensive superconductive magnets; fusion conditions could be ...
Zollino, G., Escande, D., Ricco, G., Osipenko, M., Zuin, M., Agostinetti, P., Bettini, P., Casagrande, Riccardo0001716726208020027997979735644790060000-0002-3137-426225C86F76-FA48-11E7-96FE-86B611A95AF2, Ripani, M., Piovan, R., Puiatti, M. E., Bustreo, C., Cavazzana, R., Casagrande, Riccardo, Valisa, M., Panza, F.   +15 more
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

A novel discontinuous-Galerkin deterministic neutronics model for fusion applications: development and benchmarking

Nuclear Fusion
Neutron interactions in a fusion power plant play a pivotal role in determining critical design parameters such as coil-plasma distance and breeding blanket composition. Fast predictive neutronic capabilities are therefore crucial for an efficient design
Timo J. Bogaarts, Felix Warmer
doaj   +1 more source

Cassette blanket and vacuum building: key elements in fusion reactor maintenance [PDF]

, 1977
The integration of two concepts important to fusion power reactors is discussed. The first concept is the vacuum building which improves upon the current fusion reactor designs.
Werner, R.W.
core