Results 71 to 80 of about 42,458 (304)

Conceptual design of the enhanced coolant purification systems for the European HCLL and HCPB test blanket modules [PDF]

, 2019
The Coolant Purification Systems (CPSs) is one of the most relevant ancillary systems of European Helium Cooled Lead Lithium (HCLL) and Helium Cooled Pebble Bed (HCPB) Test Blanket Modules (TBMs) which are currently in the preliminary design phase in ...
Aiello A., Arena P., Di Maio P. A., Ferrucci B., Forte R., Galabert J., Granieri M., Ortiz C., Ricapito I., Tincani A., Voukelatou K.   +10 more
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Recent Fusion Research in the National Institute for Fusion Science [PDF]

, 2011
The National Institute for Fusion Science (NIFS), which was established in 1989, promotes academic approaches toward the exploration of fusion science for steady-state helical reactor and realizes the establishment of a comprehensive understanding of ...
Akio KOMORI, Akio SAGARA, Hiroshi YAMADA, Ritoku HORIUCHI, Satoru SAKAKIBARA, Team NIFS, Yasuhiko TAKEIRI   +6 more
core   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Research on the optimization method of tritium release efficiency in a water cooled blanket for CFETR

AIP Advances
The Chinese Fusion Engineering Test Reactor (CFETR) is a tokamak device located between ITER and DEMO, with the primary goal of generating useable fusion energy through D–T reactions.
Jie Li, Xianbing Xiang, Xiaoyi Zeng, Haiyan Yang, Jie Zhang   +4 more
doaj   +1 more source

Mixed convection in a downward flow in a vertical duct with strong transverse magnetic field

, 2018
The downward flow in a vertical duct with one heated and three thermally insulated walls is analyzed numerically using the two-dimensional approximation valid in the asymptotic limit of an imposed strong transverse magnetic field.
Zhang, Xuan, Zikanov, Oleg
core   +1 more source

Fusion blankets for high efficiency power cycles [PDF]

, 1980
The efficiencies of blankets for fusion reactors are usually in the range of 30 to 40%, limited by the operating temperature (500/sup 0/C) of conventional structural materials such as stainless steels. In this project two-zone blankets are proposed; these blankets consist of a low-temperature shell surrounding a high-temperature interior zone. A survey
Powell, J R, Fillo, J A, Horn, F L, Lazareth, O W, Usher, J L   +4 more
openaire   +2 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Magnetohydrodynamic flow and heat transfer around a heated cylinder of arbitrary conductivity [PDF]

, 2017
The interaction of the liquid metal with the plasma confinement magnetic field constitutes a challenge for the design of fusion reactor blankets, due to the arise of MHD effects: increased pressure drops, heat transfer suppression, etc. To overcome these
Caruso, Gianfranco, Nobili, Matteo, Tassone, Alessandro   +2 more
core   +1 more source