Results 51 to 60 of about 7,813,887 (311)

Power and particle exhaust in the ST-E1 fusion power plant

Nuclear Fusion
Power exhaust challenges and potential solutions for a 5 m major radius, low-aspect ratio burning tokamak have been explored. 1D edge plasma models have been used to screen for access to detachment using short and long outer divertor legs in double and ...
M. Robinson, A. Scarabosio, E. Vekshina, J.H. Nichols, J.D. Lore, K. Borowiec, J. Varje, S.M. Levine, M. Scarpari, E.N.J. Maartensson, X. Zhang, R. Kamenicky, J. Alexander, M. Jackson, C. Marsden, S.A.M. McNamara, R. Maingi   +16 more
doaj   +1 more source

Considering for the blanket structure scheme of HCCB DEMO

Theoretical and Applied Mechanics Letters, 2019
: For the solid blanket concept of helium cooled ceramic breeder (HCCB) demonstration fusion power plant (DEMO), a feasible blanket structure with configuration 2×X is proposed as considering relatively low temperature limit of neutron multiplier ...
Zhou Zhao, Zaixin Li, Xiaoyu Wang, Xueren Wang, Kaiming Feng   +4 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Design scoping and systems modelling of ST-E1 using the PyTok power plant simulation code

Nuclear Fusion
To support the pre-concept design of Tokamak Energy’s (TEs) ST-E1 fusion power plant, we developed a new systems code, PyTok. PyTok codifies plasma physics and engineering constraints within a pure Python, object-oriented framework designed for rapid ...
C.L. Wilson, J. Astbury, M.J. Ginsberg, N. Hinton, E.N.J. Maartensson, S.A.M. McNamara, J. Willis, E. Yildirim, the ST-E1 Team   +8 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Maintenance strategy, structural design, and site layout of the ST-E1 fusion power plant

Nuclear Fusion
An effective fusion reactor maintenance scheme enables safe operations and short downtimes. This in turn leads to high availability, which is critical to the commercial viability of a power-producing plant.
J. Willis, K. Chandrasekhar, P. Cheema, J. England, V. Godhani, E. Guise, S.M. Levine, R. Pocock, A. Scott, A. Shone, R. Thwaites, P. Titus, C. Wilson, the ST-E1 Team   +13 more
doaj   +1 more source

Reference commercial fusion power plants [PDF]

, 1976
Currently available conceptual designs for commercial fusion power plants are for first generation plants using deuterium-tritium (D-T) fuel, and are all functionally similar. This similarity has been used as a basis for defining an envelope of D-T fusion power plant characteristics which encompasses the characteristics of the available designs.
Young, J. R., Gore, B. F.
openaire   +2 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source