Results 61 to 70 of about 8,177,292 (310)

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Maintenance strategy, structural design, and site layout of the ST-E1 fusion power plant

Nuclear Fusion
An effective fusion reactor maintenance scheme enables safe operations and short downtimes. This in turn leads to high availability, which is critical to the commercial viability of a power-producing plant.
J. Willis, K. Chandrasekhar, P. Cheema, J. England, V. Godhani, E. Guise, S.M. Levine, R. Pocock, A. Scott, A. Shone, R. Thwaites, P. Titus, C. Wilson, the ST-E1 Team   +13 more
doaj   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tokamak Energy’s pre-concept design for a fusion power plant: an overview of ST-E1

Nuclear Fusion
Climate change and rapidly rising energy demand, driven in part by artificial intelligence and data-centre growth, create an urgent need for stable, low-carbon, and abundant power. Fusion is a promising long-term solution, yet its commercialisation faces
J. Willis, S.A.M. McNamara, E.N.J. Maartensson, J. Astbury, E. Yildirim, N. Hinton, C.L. Wilson, X. Zhang, J.W. Berkery, L. Baylor, M. Shimada, H. Flynn, A.O. Nelson, S. Abouelazayem, A. Alieva, T. Anderson, J. Benayas, L. Black, M. Borscz, M. Bristow, S. Brown, P. Bunting, A. Burchill, K. Chandrasekhar, P. Cheema, O. Danisworo, A. Dnestrovskii, A.V. Dudkovskaia, J. England, J. Fowler, V. Godhani, E. Guise, S. Irukuvarghula, D. James, F. Janky, G.S. Kamal, J. Kang, M. Kruip, A. Kumar, V.Y.S. Lee, S.M. Levine, J. Lima, N.A. Lopez, I. Loughran, F. Malinowski, C. Marsden, L. Mateescu, A.F.P. McAdam, S.Y. Medvedev, M. Michalopoulou, M.K.E. Mohamed, J. Naish, G. Naylor, D. O’Dea, J. Pickles, R. Pocock, M. Robinson, M. Romanelli, S. Romanelli, A. Scarabosio, M. Scarpari, A. Scott, A. Shone, A. Sladkomedova, A. Soldatova, T. Srawley, J. Stirling, G. Stoneham, R. Suhardjo, Y. Takase, J. Taylor, S. Terry, R. Thwaites, J. Trueba, B. van Nugteren, J. Varje, E. Vekshina, B. Vincent, A. Vorobev, A.L. Washington II, N. Welch, A. Whitehead, M. Whitfield, E. Wooldridge, M. Ginsberg   +84 more
doaj   +1 more source

A Sensitivity Analysis on Design of the EU-DEMO Steady-State Electrical Power Distribution Grid via Monte Carlo-Based Probabilistic Power Flow Models

IEEE Access
The EU-DEMO (EUropean DEMOnstration Power Plant) fusion reactor is one of the most ambitious energy projects aiming at demonstrating the feasibility of nuclear fusion to be a clean, safe, and sustainable source of energy.
M. Caldora, S. Panella, M. C. Falvo, S. Minucci, A. Ferro, T. Franke   +5 more
doaj   +1 more source

A costing framework for fusion power plants

CoRR
This paper summarizes and consolidates fusion power-plant costing work performed in support of ARPA-E from 2017 through 2024, and documents the evolution of the associated analysis framework from early capital-cost-focused studies to a standards-aligned, auditable costing capability.
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Integrated physics and magnet design for the ST-E1 fusion power plant

Nuclear Fusion
ST-E1 is Tokamak Energy’s commercially competitive fusion power plant design featuring a lifetime high-temperature superconducting (HTS) magnet cage, which has completed its pre-concept design stage.
E.N.J. Maartensson, N. Welch, M. Scarpari, F. Malinowski, M. Borscz, M. Bristow, P.F. Buxton, J. Kang, M. Kruip, A.V. Langtry, N.A. Lopez, C. Marsden, S.A.M. McNamara, S. Medvedev, Y. Takase, P. Thomas, B. van Nugteren, C.L. Wilson, X. Zhang, the ST-E1 Team   +19 more
doaj   +1 more source

Edge-enhanced SAM for extracting photovoltaic power plants from remote sensing imagery

International Journal of Applied Earth Observations and Geoinformation
Accurate geospatial extent data of photovoltaic (PV) power plants is essential for assessing their socioeconomic benefits and environmental impacts. However, existing semantic segmentation models often result in over-smoothed edges and the inaccurate ...
Yuehong Chen, Jiayue Zhou, Yu Chen, Jiawei Wang, Xiaoxiang Zhang, Yong Ge, Hongyuan Ma   +6 more
doaj   +1 more source