Results 111 to 120 of about 7,427,824 (408)

Computation-Aided Design of Albumin Affibody-Inserted Antibody Fragment for the Prolonged Serum Half-Life

Pharmaceutics, 2022
Single-chain variable fragments (scFvs) have been recognized as promising agents in cancer therapy. However, short serum half-life of scFvs often limits clinical application.
Na Hyun Kwon, Jae Hun Lee, Inchan Kwon
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

RNAseq analysis of fast skeletal muscle in restriction-fed transgenic coho salmon (Oncorhynchus kisutch) : an experimental model uncoupling the growth hormone and nutritional signals regulating growth [PDF]

, 2015
Background Coho salmon (Oncorhynchus kisutch) transgenic for growth hormone (Gh) express Gh in multiple tissues which results in increased appetite and continuous high growth with satiation feeding. Restricting Gh-transgenics to the same lower ration (TR)
Devlin, Robert, Garcia de la Serrana Castillo, Daniel, Johnston, Ian Alistair   +2 more
core   +2 more sources

Human Cytomegalovirus (HCMV) Glycoprotein gB Promotes Virus Entry In Trans Acting as the Viral Fusion Protein Rather than as a Receptor-Binding Protein

mBio, 2013
Human cytomegalovirus (HCMV) glycoproteins gB and gH/gL are both necessary and sufficient for cell-cell fusion. However, it is not clear what roles these glycoproteins play in virus entry, whether acting directly in membrane fusion or in binding ...
Paul T. Wille, T. Wisner, Brent J. Ryckman, David C. Johnson   +3 more
semanticscholar   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine

Cellular & Molecular Immunology, 2020
The outbreak of Coronavirus Disease 2019 (COVID-19) has posed a serious threat to global public health, calling for the development of safe and effective prophylactics and therapeutics against infection of its causative agent, severe acute respiratory ...
Wanbo Tai, Lei He, Xiujuan Zhang, J. Pu, D. Voronin, Shibo Jiang, Yusen Zhou, L. Du   +7 more
semanticscholar   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Pharmacokinetic Characterization and Tissue Distribution of Fusion Protein Therapeutics by Orthogonal Bioanalytical Assays and Minimal PBPK Modeling

Molecules, 2020
Characterization of pharmacokinetic (PK) properties and target tissue distribution of therapeutic fusion proteins (TFPs) are critical in supporting in vivo efficacy.
Hiroshi Sugimoto, Susan Chen, Mark G. Qian   +2 more
doaj   +1 more source

Mycobacterium tuberculosis antigen 85B and ESAT-6 expressed as a recombinant fusion protein in Mycobacterium smegmatis elicits cell-mediated immune response in a murine vaccination model [PDF]

, 2013
This is the post-print version of the final paper published in Molecular Immunology. The published article is available from the link below. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting ...
Aagaard, Agger, Andersen, Andersen, Anthony G. Tsolaki, Bennekov, Blokpoel, Brian D. Robertson, Carroll, Crowe, Curcic, Delogu, Delogu, DeMaio, Dietrich, Dye, Dziadek, Ehrt, Fine, Garbe, Gupta, Hanekom, Ida Rosenkrands, Judit Nagy, Laemmli, Langermans, Maher, Masungi, Menozzi, Menozzi, Okkels, Olsen, O’Donnell, Parish, Pethe, Roche, Russell, Sambrook, Sergio Leiva, Temmerman, Triccas, Triccas, Tsolaki, Uday Kishore, van Dissel, van Dissel, Weinrich Olsen, Wiles, Williams   +48 more
core   +1 more source

Gamete Fusion: Key Protein Identified [PDF]

Current Biology, 2008
Is there a common mechanism of eukaryotic sex? Two recent reports highlight an ancient and widely distributed protein that is key to gamete fusion and is a potential target for malaria vaccines.
Geoffrey I. McFadden, Christopher D. Goodman   +1 more
openaire   +3 more sources