Results 121 to 130 of about 7,427,824 (408)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Frontiers in Microbiology, 2019 Bacteriophage endolysins and bacterial exolysins are capable of enzymatic degradation of the cell wall peptidoglycan layer and thus show promise as a new class of antimicrobials. Both exolysins and endolysins often consist of different modules, which are
Linnea C. Hjelm +4 more
doaj +1 more source
Repressor fusions as a tool to study protein–protein interactions [PDF]
Structure, 1995 Genetic reporter systems are necessarily limited in the kinds of information they can provide. The most obvious limitation is that the insides of cells are complex. The phenotype of a gene fusion protein will be determined not only by the property we wish to assay, but also by other effects of the intracellular environment on the chimeric gene product,
openaire +3 more sources
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Complementation between mouse Mfn1 and Mfn2 protects mitochondrial fusion defects caused by CMT2A disease mutations [PDF]
, 2007 Mfn2, an oligomeric mitochondrial protein important for mitochondrial fusion, is mutated in Charcot-Marie-Tooth disease (CMT) type 2A, a peripheral neuropathy characterized by axonal degeneration.
Chan, David C., Detmer, Scott A.
core +2 more sources
CCT4 promotes tunneling nanotube formation
FEBS Letters, EarlyView.Tunneling nanotubes (TNTs) are membranous tunnel‐like structures that transport molecules and organelles between cells. They vary in thickness, and thick nanotubes often contain microtubules in addition to actin fibers. We found that cells expressing monomeric CCT4 generate many thick TNTs with tubulin.
Miyu Enomoto +3 more
wiley +1 more source
Vacuolar transport and function of Saccharomyces cerevisiae sterol ester hydrolase Tgl1
FEBS Letters, EarlyView.Tgl1, one of yeast sterol ester hydrolases, had been found on the lipid droplets where sterol esters are mainly stored. This study revealed that Tgl1 is transported into the vacuole depending on the ESCRT‐I–III complex, and that it exhibits intra‐vacuolar sterol ester hydrolase activity.
Takumi Nakatsuji +5 more
wiley +1 more source
浙江大学学报. 农业与生命科学版, 2008 In order to construct the good immunogenic α-β1-β2 fusion protein, a 0.95 kb gene fragment from plasmid pETXA1 containing Clostridium perfringens type C alpha-toxin gene was amplified by PCR and it was inserted into recombinant plasmid pETXB1β2 ...
XU Chong-bo +4 more
doaj +1 more source
Molecular Principles of Gene Fusion Mediated Rewiring of Protein Interaction Networks in Cancer [PDF]
, 2016 Gene fusions are common cancer-causing mutations, but the molecular principles by which fusion protein products affect interaction networks and cause disease are not well understood.
Babu, M. Madan +7 more
core +2 more sources
Journal of Virology, 2020 The COVID-19 pandemic, caused by SARS-CoV-2, presents a serious global public health emergency in urgent need of prophylactic and therapeutic interventions.
Yuanmei Zhu +4 more
semanticscholar +1 more source