Results 11 to 20 of about 7,541,115 (355)

An unusual tandem kinase fusion protein confers leaf rust resistance in wheat

Nature Genetics, 2023
The introgression of chromosome segments from wild relatives is an established strategy to enrich crop germplasm with disease-resistance genes1. Here we use mutagenesis and transcriptome sequencing to clone the leaf rust resistance gene Lr9, which was ...
Yajun Wang, M. Abrouk, S. Gourdoupis, D. Koo, M. Karafiátová, I. Molnár, K. Holušová, J. Doležel, Naveenkumar Athiyannan, Emile Cavalet-Giorsa, Łukasz Jaremko, J. Poland, S. Krattinger   +12 more
semanticscholar   +1 more source

Rab22a-NeoF1 fusion protein promotes osteosarcoma lung metastasis through its secretion into exosomes

Signal Transduction and Targeted Therapy, 2021
It remains unknown for decades how some of the therapeutic fusion proteins positive in a small percentage of cancer cells account for patient outcome. Here, we report that osteosarcoma Rab22a-NeoF1 fusion protein, together with its binding partner PYK2 ...
L. Zhong, D. Liao, Jingjing Li, Wenqiang Liu, Jingxuan Wang, Cuiling Zeng, Xin Wang, Zhiliang Cao, Ruhua Zhang, Miao Li, Kuntai Jiang, Y. Zeng, J. Sui, Tiebang Kang   +13 more
semanticscholar   +1 more source

Fusion protein strategies for cryo-EM study of G protein-coupled receptors

Nature Communications, 2021
Single particle cryogenic-electron microscopy (cryo-EM) is used extensively to determine structures of activated G protein-coupled receptors (GPCRs) in complex with G proteins or arrestins. However, applying it to GPCRs without signaling proteins remains
Kaihua Zhang, Hao Wu, N. Hoppe, A. Manglik, Yifan Cheng   +4 more
semanticscholar   +1 more source

Construction of a Collagen-like Protein Based on Elastin-like Polypeptide Fusion and Evaluation of Its Performance in Promoting Wound Healing

Molecules, 2023
In the healing of wounds, human-like collagen (hCol) is essential. However, collagen-based composite dressings have poor stability in vivo, which severely limits their current therapeutic potential.
Yingli Chen, Yuanyuan Wu, Fengmin Xiong, Wei Yu, Tingting Wang, Jingjing Xiong, Luping Zhou, Fei Hu, Xianlong Ye, Xinmiao Liang   +9 more
doaj   +1 more source

Avian Paramyxovirus Type 1 in Egypt: Epidemiology, Evolutionary Perspective, and Vaccine Approach

Frontiers in Veterinary Science, 2021
Avian orthoavulavirus 1, formerly known as avian paramyxovirus type-1 (APMV-1), infects more than 250 different species of birds. It causes a broad range of clinical diseases and results in devastating economic impact due to high morbidity and mortality ...
Shimaa M. G. Mansour, Reham M. ElBakrey, Fakry F. Mohamed, Esraa E. Hamouda, Mona S. Abdallah, Ahmed R. Elbestawy, Mahmoud M. Ismail, Hanan M. F. Abdien, Amal A. M. Eid   +8 more
doaj   +1 more source

The SARS-CoV-2 protein ORF3a inhibits fusion of autophagosomes with lysosomes

Cell Discovery, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the ongoing coronavirus disease 2019 pandemic. How SARS-CoV-2 regulates cellular responses to escape clearance by host cells is unknown.
Yabin Zhang, Hao Sun, R. Pei, Binli Mao, Zhenyu Zhao, Huihui Li, Yong Lin, Kefeng Lu   +7 more
semanticscholar   +1 more source

Efficient Expression of Soluble Recombinant Protein Fused with Core-Streptavidin in Bacterial Strain with T7 Expression System

Methods and Protocols, 2020
The limited amount of fusion protein transported into cytosol milieu has made it challenging to obtain a sufficient amount for further applications. To avoid the laborious and expensive task, T7 promoter-driving pET-30a(+) coding for chimeric gene of ...
Ammar Tarar, Esmael M. Alyami, Ching-An Peng   +2 more
doaj   +1 more source

A Novel Splice Variant of Human TGF-β Type II Receptor Encodes a Soluble Protein and Its Fc-Tagged Version Prevents Liver Fibrosis in vivo

Frontiers in Cell and Developmental Biology, 2021
We describe, for the first time, a new splice variant of the human TGF-β type II receptor (TβRII). The new transcript lacks 149 nucleotides, resulting in a frameshift and the emergence of an early stop codon, rendering a truncated mature protein of 57 ...
Marcela Soledad Bertolio, Anabela La Colla, Alejandra Carrea, Ana Romo, Gabriela Canziani, Stella Maris Echarte, Sabrina Campisano, German Patricio Barletta, Alexander Miguel Monzon, Tania Melina Rodríguez, Andrea Nancy Chisari, Ricardo Alfredo Dewey   +11 more
doaj   +1 more source

Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion

Cell Research, 2020
The recent outbreak of coronavirus disease (COVID-19) caused by SARS-CoV-2 infection in Wuhan, China has posed a serious threat to global public health.
Shuai Xia, Meiqin Liu, Chao Wang, W. Xu, Qiaoshuai Lan, Siliang Feng, Feifei Qi, L. Bao, L. Du, Shuwen Liu, C. Qin, Fei Sun, Zhènglì Shí, Yun Zhu, Shibo Jiang, Lu Lu   +15 more
semanticscholar   +1 more source

Structure of the Core Postfusion Porcine Endogenous Retrovirus Fusion Protein

mBio, 2022
Retroviral elements from endogenous retroviruses have functions in mammalian physiology. The best-known examples are the envelope proteins that function in placenta development and immune suppression.
Trevor T. Dean, Vitor Hugo B. Serrão, Jeffrey E. Lee   +2 more
doaj   +1 more source