Results 11 to 20 of about 7,331,516 (404)

Fusion-protein-assisted protein crystallization [PDF]

Acta Crystallographica Section F Structural Biology Communications, 2015
Fusion proteins can be used directly in protein crystallization to assist crystallization in at least two different ways. In one approach, the ‘heterologous fusion-protein approach’, the fusion partner can provide additional surface area to promote ...
Kobe, Bostjan, Ve, Thomas, Williams, Simon J.   +2 more
core   +6 more sources

A Pan-Pneumovirus vaccine based on immunodominant epitopes of the fusion protein

Frontiers in Immunology, 2022
Respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) are two leading causes of severe respiratory infections in children, the elderly, and immunocompromised patients.
Jiachen Huang, Jiachen Huang, Rose J. Miller, Rose J. Miller, Jarrod J. Mousa, Jarrod J. Mousa, Jarrod J. Mousa   +6 more
doaj   +1 more source

Protective antibodies against human parainfluenza virus type 3 infection

mAbs, 2021
Human parainfluenza virus type III (HPIV3) is a common respiratory pathogen that afflicts children and can be fatal in vulnerable populations, including the immunocompromised. There are currently no effective vaccines or therapeutics available, resulting
Jim Boonyaratanakornkit, Suruchi Singh, Connor Weidle, Justas Rodarte, Ramasamy Bakthavatsalam, Jonathan Perkins, Guillaume B.E. Stewart-Jones, Peter D. Kwong, Andrew T. McGuire, Marie Pancera, Justin J. Taylor   +10 more
doaj   +1 more source

Adult Memory T Cell Responses to the Respiratory Syncytial Virus Fusion Protein During a Single RSV Season (2018–2019)

Frontiers in Immunology, 2022
Respiratory Syncytial Virus (RSV) is ubiquitous and re-infection with both subtypes (RSV/A and RSV/B) is common. The fusion (F) protein of RSV is antigenically conserved, induces neutralizing antibodies, and is a primary target of vaccine development ...
Brittani N. Blunck, Laura S. Angelo, David Henke, Vasanthi Avadhanula, Matthew Cusick, Laura Ferlic-Stark, Lynn Zechiedrich, Lynn Zechiedrich, Lynn Zechiedrich, Brian E. Gilbert, Pedro A. Piedra, Pedro A. Piedra   +11 more
doaj   +1 more source

The FUSION protein crystallization screen

Journal of Applied Crystallography, 2022
The success and speed of atomic structure determination of biological macromolecules by X-ray crystallography depends critically on the availability of diffraction-quality crystals. However, the process of screening crystallization conditions often consumes large amounts of sample and time.
Gorrec, Fabrice, Bellini, Dom
openaire   +3 more sources

Fusion Protein Cleavage Site Containing Three Basic Amino Acids Attenuates Newcastle Disease Virus in Chicken Embryos: Use as an in ovo Vaccine

Frontiers in Microbiology, 2022
In ovo vaccination is an attractive immunization strategy for the poultry industry. However, although most live Newcastle disease virus (NDV) vaccine strains, such as LaSota and V4, can be used after hatching, they are pathogenic to chicken embryos when ...
Helong Feng, Helong Feng, Helong Feng, Helong Feng, Yu Shang, Yu Shang, Yu Shang, Li Li, Li Li, Li Li, Xiuxiu Sun, Sanling Fan, Sanling Fan, Sanling Fan, Xiangfei Ren, Xiangfei Ren, Xiangfei Ren, Yingying Xu, Yingying Xu, Yingying Xu, Zhe Zeng, Zhe Zeng, Zhe Zeng, Xingxing Hu, Xingxing Hu, Xingxing Hu, Guofu Cheng, Guoyuan Wen, Guoyuan Wen, Guoyuan Wen   +29 more
doaj   +1 more source

Bacterium-Like Particles Displaying the Rift Valley Fever Virus Gn Head Protein Induces Efficacious Immune Responses in Immunized Mice

Frontiers in Microbiology, 2022
Rift Valley fever virus (RVFV), a mosquito-borne zoonotic phlebovirus, causes serious disease in humans and ruminants. According to the World Health Organization, Rift Valley fever is classified as a priority disease, and as such, vaccine development is ...
Shengnan Zhang, Feihu Yan, Dongping Liu, Entao Li, Na Feng, Shengnan Xu, Hualei Wang, Yuwei Gao, Songtao Yang, Yongkun Zhao, Xianzhu Xia   +10 more
doaj   +1 more source

Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion

Cell Research, 2020
The recent outbreak of coronavirus disease (COVID-19) caused by SARS-CoV-2 infection in Wuhan, China has posed a serious threat to global public health.
Shuai Xia, Meiqin Liu, Chao Wang, W. Xu, Qiaoshuai Lan, Siliang Feng, Feifei Qi, L. Bao, L. Du, Shuwen Liu, C. Qin, Fei Sun, Zhènglì Shí, Yun Zhu, Shibo Jiang, Lu Lu   +15 more
semanticscholar   +1 more source

Evaluation of the Effects of Human Beta-Interferon Scaffold Attachment Region (IFN-SAR) on Expression of Vascular Endothelial Growth Factor-Fc (VEGF-Fc) Fusion Protein Expression in Chinese Hamster Ovary (CHO) Cells [PDF]

Pharmaceutical Sciences, 2020
Background: Recombinant anti-vascular endothelial growth factor (VEGF) monoclonal antibodies and Fc-fusion proteins have been widely used for the effective treatment of retinal neovascular diseases.
Ehsan Naghneh, Es'hagh Pourmaleki, Azam Rahimpour   +2 more
doaj   +1 more source

Structure of the Core Postfusion Porcine Endogenous Retrovirus Fusion Protein

mBio, 2022
Retroviral elements from endogenous retroviruses have functions in mammalian physiology. The best-known examples are the envelope proteins that function in placenta development and immune suppression.
Trevor T. Dean, Vitor Hugo B. Serrão, Jeffrey E. Lee   +2 more
doaj   +1 more source