Results 11 to 20 of about 7,427,824 (408)
GENOTYPING AND GENETIC EVOLUTION ANALYSIS OF NEWLY ISOLATED NEWCASTLE DISEASE VIRUS IN EGYPT
Slovenian Veterinary Research, 2021 In spite of enormous vaccination programs that were implemented in the Egyptian poultry farms, Newcastle Disease Virus (NDV) remains one of the major concerns to the poultry industry.
Yahia Madbouly +5 more
doaj +1 more source
An unusual tandem kinase fusion protein confers leaf rust resistance in wheat
Nature Genetics, 2023 The introgression of chromosome segments from wild relatives is an established strategy to enrich crop germplasm with disease-resistance genes1. Here we use mutagenesis and transcriptome sequencing to clone the leaf rust resistance gene Lr9, which was ...
Yajun Wang +12 more
semanticscholar +1 more source
OncoImmunology, 2023 Mesothelin (MSLN) is an attractive immuno-oncology target, but the development of MSLN-targeting therapies has been impeded by tumor shedding of soluble MSLN (sMSLN), on-target off-tumor activity, and an immunosuppressive tumor microenvironment.
Daniel Snell +22 more
doaj +1 more source
Signal Transduction and Targeted Therapy, 2021 It remains unknown for decades how some of the therapeutic fusion proteins positive in a small percentage of cancer cells account for patient outcome. Here, we report that osteosarcoma Rab22a-NeoF1 fusion protein, together with its binding partner PYK2 ...
L. Zhong +13 more
semanticscholar +1 more source
Fusion protein strategies for cryo-EM study of G protein-coupled receptors
Nature Communications, 2021 Single particle cryogenic-electron microscopy (cryo-EM) is used extensively to determine structures of activated G protein-coupled receptors (GPCRs) in complex with G proteins or arrestins. However, applying it to GPCRs without signaling proteins remains
Kaihua Zhang +4 more
semanticscholar +1 more source
Evaluation and Comparison of Clostridium Epsilon-Alpha Fusion Gene Expression Using Different Commercial Expression Vector [PDF]
Archives of Razi Institute, 2021 Clostridium perfringens and Clostridium septicum are gram-positive, anaerobic, spore-forming rods and pathogens for humans and livestock, which are widespread in nature as well as human and animal digestive systems. C.
H. R Sepehrifar +3 more
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A Compensatory Mutation Provides Resistance to Disparate HIV Fusion Inhibitor Peptides and Enhances Membrane Fusion [PDF]
, 2013 Fusion inhibitors are a class of antiretroviral drugs used to prevent entry of HIV into host cells. Many of the fusion inhibitors being developed, including the drug enfuvirtide, are peptides designed to competitively inhibit the viral fusion protein ...
A Adachi +41 more
core +23 more sources
Frontiers in Microbiology, 2022 In ovo vaccination is an attractive immunization strategy for the poultry industry. However, although most live Newcastle disease virus (NDV) vaccine strains, such as LaSota and V4, can be used after hatching, they are pathogenic to chicken embryos when ...
Helong Feng +29 more
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Biomedicines, 2022 Ewing sarcoma (EwS), a type of bone and soft tissue tumor, is mainly driven by the expression of the fusion protein EWSR1-FLI1. Upon binding to chromatin, EWSR1-FLI1 reprograms the epigenetic state, alters gene expression, and thus leads to tumorigenesis.
Mingli Li, Chun-Wei Chen
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Cloning and Expression of a Fusion Protein Containing Highly Epitopic Regions of Clostridium perfringens Epsilon Toxin and Clostridium novyi Alpha Toxin [PDF]
Journal of Cell and Molecular Research, 2021 Clostridium perfringens and novyi species are two important toxin-producing pathogens which pose a risk to the livestock health. Epsilon and alpha toxins are major toxins of these two pathogens, respectively. Advances in current vaccine industrialization
Mohsen Mehrvarz +3 more
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