Results 371 to 380 of about 7,331,516 (404)
Some of the next articles are maybe not open access.
Science, 1985
Foreign DNA fragments can be inserted into filamentous phage gene III to create a fusion protein with the foreign sequence in the middle. The fusion protein is incorporated into the virion, which retains infectivity and displays the foreign amino acids ...
G. P. Smith
semanticscholar +1 more source
Foreign DNA fragments can be inserted into filamentous phage gene III to create a fusion protein with the foreign sequence in the middle. The fusion protein is incorporated into the virion, which retains infectivity and displays the foreign amino acids ...
G. P. Smith
semanticscholar +1 more source
Antibody–cytokine fusion proteins
Archives of Biochemistry and Biophysics, 2012Cytokines are key players in stimulating and regulating immune responses in physiological and pathophysiological processes. Various cytokines have been approved for therapy of cancer and other diseases and many more are under development. However, therapeutic efficacy is often hampered by severe side effects and poor pharmacokinetic properties.
openaire +3 more sources
Fusion Proteins in Retroviral Transformation
1985Publisher Summary Retroviral transforming proteins are coded for by oncogenes. The mechanism of the uptake of oncogenes by retroviruses often results in fusion with replicative genes. Fusion of oncogenes to retroviral replicative genes generates protein products that are also fused.
openaire +3 more sources
Fusion of classifiers for predicting protein–protein interactions
Neurocomputing, 2005Prediction of protein-protein interaction is a difficult and an important problem in biology. In this paper, we describe a very general method for predicting protein-protein interactions. The interaction mining approach is demonstrated by building a learning system based on experimentally validated protein-protein interactions in the human gastric ...
openaire +2 more sources
Fusion protein with a toxin and scaffold protein
2020The present invention relates to the field of structural biology and drug discovery. More specifically, the present invention relates to novel fusion proteins, their uses and methods in three-dimensional structural analysis of macromolecules, such as X-ray crystallography and high-resolution Cryo-EM, and their use in structure-based drug design and ...
Steyaert, Jan, Pardon, Els, Vranken, Wim
openaire +2 more sources
Design of fusion proteins for biocatalysis
The use of enzymes to convert substrates into valuable products has been an integral part of biocatalysis. However, some reactions are energy-demanding that requires the use of NAD(P)H to proceed. This NAD(P)H can be costly impeding the progress of enzyme usage at a bigger scale.Beyzanur, Celebi +3 more
openaire +2 more sources
Mapping protein-protein interactions with alkaline phosphatase fusion proteins
2001Publisher Summary This chapter describes a convenient and versatile method for determining the molecular recognition properties of SH3 domains, using bacterial alkaline phosphatase as a fusion protein. A variety of proteins or peptides have been fused to the N terminus of alkaline phosphatase (AP) by genetic engineering, including antibody chains and
Brian K. Kay, Montarop Yamabhai
openaire +3 more sources
Targeting chromatin complexes in fusion protein-driven malignancies
Nature Reviews. Cancer, 2019Gerard L. Brien +2 more
semanticscholar +1 more source
Synthetic fusion protein design and applications.
Biotechnology Advances, 2015Kai Yu +3 more
semanticscholar +1 more source