Results 51 to 60 of about 7,541,115 (355)

Melittin-MIL-2 fusion protein as a candidate for cancer immunotherapy

Journal of Translational Medicine, 2016
BackgroundCytokine fusion protein that modulates the immune response holds great potential for cancer immunotherapy. IL-2 is an effective treatment against advanced cancers. However, the therapeutic efficacy of IL-2 is limited by severe systemic toxicity.
Mingjun Liu, Hai-tao Wang, Linjie Liu, Bin Wang, Guirong Sun   +4 more
semanticscholar   +1 more source

Antigenic Site-Specific Competitive Antibody Responses to the Fusion Protein of Respiratory Syncytial Virus Were Associated With Viral Clearance in Hematopoietic Cell Transplantation Adults

Frontiers in Immunology, 2019
Background: Recent studies of human sera showed that the majority of the respiratory syncytial virus (RSV) neutralizing antibodies are directed against pre-fusion conformation of the fusion (F) protein of RSV and revealed the importance of pre-fusion ...
Xunyan Ye, Obinna P. Iwuchukwu, Vasanthi Avadhanula, Letisha O. Aideyan, Trevor J. McBride, Laura L. Ferlic-Stark, Kirtida D. Patel, Felipe-Andres Piedra, Dimpy P. Shah, Roy F. Chemaly, Pedro A. Piedra, Pedro A. Piedra   +11 more
doaj   +1 more source

Identification of a Novel Self-Sufficient Styrene Monooxygenase from Rhodococcus opacus 1CP. [PDF]

, 2009
Sequence analysis of a 9-kb genomic fragment of the actinobacterium Rhodococcus opacus 1CP led to identification of an open reading frame encoding a novel fusion protein, StyA2B, with a putative function in styrene metabolism via styrene oxide and ...
Berkel, W.J.H., van, Eulberg, D., Kaschabek, S.R., Lakner, S., Schloemann, M., Tischler, D.   +5 more
core   +4 more sources

Functional implications of respiratory syncytial virus F sequence variability: a comparative analysis using contemporary RSV isolates

mSphere
Respiratory syncytial virus (RSV) remains a major global health issue. Therapeutic options are limited, but new prophylactics, all targeting the fusion (F) glycoprotein, were recently licensed.
Kim Stobbelaar, Lotte Jacobs, Francisco I. Serrano-Cano, Axelle Fransen, Winke Van der Gucht, Annemieke Smet, Benedicte Y. De Winter, Paul Cos, Winnok de Vos, Kim Van Hoorenbeeck, Stijn Verhulst, Peter L. Delputte   +11 more
doaj   +1 more source

OPA1 mutation and late-onset cardiomyopathy: mitochondrial dysfunction and mtDNA instability. [PDF]

, 2012
BackgroundMitochondrial fusion protein mutations are a cause of inherited neuropathies such as Charcot-Marie-Tooth disease and dominant optic atrophy.
Bers, Donald M, Chen, Le, Chiamvimonvat, Nipavan, Cortopassi, Gino, Davies, Vanessa, Knowlton, Anne A, Liu, Tingting, Lu, Xiyuan, Tomilov, Alexey A, Tran, Alice, Votruba, Marcela   +10 more
core   +2 more sources

Domain interactions within Fzo1 oligomers are essential for mitochondrial fusion [PDF]

, 2006
Mitofusins are conserved GTPases essential for the fusion of mitochondria. These mitochondrial outer membrane proteins contain a GTPase domain and two or three regions with hydrophobic heptad repeats, but little is known about how these domains interact ...
Chan, David C., Griffin, Erik E.
core   +3 more sources

Recurrent De Novo NAHR Reciprocal Duplications in the ATAD3 Gene Cluster Cause a Neurogenetic Trait with Perturbed Cholesterol and Mitochondrial Metabolism. [PDF]

, 2020
Recent studies have identified both recessive and dominant forms of mitochondrial disease that result from ATAD3A variants. The recessive form includes subjects with biallelic deletions mediated by non-allelic homologous recombination.
Armstrong, C, Baple, E, Baptista, J, Caswell, R, Cunningham, MH, Dean, J, Durigon, R, Durlacher-Betzer, K, Ellard, S, Fernandez Pelayo, U, Grochowski, CM, Gunning, AC, Harel, T, Holt, IJ, Homfray, T, Jones, AWE, Lahiri, N, Lupski, JR, Misra, VK, Muñoz Oreja, M, Parrish, A, Scurr, I, Spinazzola, A, Stals, KL, Strucinska, K, Taylor, RW, Tysoe, C, Wright, CF, Yoon, WH   +28 more
core   +3 more sources

Pre-fusion structure of a human coronavirus spike protein

Nature, 2016
HKU1 is a human betacoronavirus that causes mild yet prevalent respiratory disease, and is related to the zoonotic SARS and MERS betacoronaviruses, which have high fatality rates and pandemic potential.
R. Kirchdoerfer, C. Cottrell, Nianshuang Wang, J. Pallesen, Hadi M. Yassine, H. Turner, Kizzmekia S. Corbett, B. Graham, J. McLellan, A. Ward   +9 more
semanticscholar   +1 more source

Passaging of a Newcastle disease virus pigeon variant in chickens results in selection of viruses with mutations in the polymerase complex enhancing virus replication and virulence [PDF]

, 2010
Some Newcastle disease virus (NDV) variants isolated from pigeons (pigeon paramyxovirus type 1; PPMV-1) do not show their full virulence potential for domestic chickens but may become virulent upon spread in these animals.
Dortmans, J.C.F.M., Koch, G., Peeters, B.P.H., Rottier, P.J.M.   +3 more
core   +2 more sources

Respiratory Syncytial Virus Fusion Protein Promotes TLR-4–Dependent Neutrophil Extracellular Trap Formation by Human Neutrophils

PLoS ONE, 2015
Acute viral bronchiolitis by Respiratory Syncytial Virus (RSV) is the most common respiratory illness in children in the first year of life. RSV bronchiolitis generates large numbers of hospitalizations and an important burden to health systems ...
Giselle A. Funchal, N. Jaeger, R. Czepielewski, M. S. Machado, S. Muraro, R. Stein, C. Bonorino, B. Porto   +7 more
semanticscholar   +1 more source