Results 51 to 60 of about 7,331,516 (404)

Synthetic protein scaffolds based on peptide motifs and cognate adaptor domains for improving metabolic productivity

Frontiers in Bioengineering and Biotechnology, 2015
The efficiency of many cellular processes relies on the defined interaction among different proteins within the same metabolic or signaling pathway. Consequently, a spatial colocalization of functionally interacting proteins has frequently emerged during
Anselm H.C. Horn, Heinrich eSticht
doaj   +1 more source

Melittin-MIL-2 fusion protein as a candidate for cancer immunotherapy

Journal of Translational Medicine, 2016
BackgroundCytokine fusion protein that modulates the immune response holds great potential for cancer immunotherapy. IL-2 is an effective treatment against advanced cancers. However, the therapeutic efficacy of IL-2 is limited by severe systemic toxicity.
Mingjun Liu, Hai-tao Wang, Linjie Liu, Bin Wang, Guirong Sun   +4 more
semanticscholar   +1 more source

Antigenic Site-Specific Competitive Antibody Responses to the Fusion Protein of Respiratory Syncytial Virus Were Associated With Viral Clearance in Hematopoietic Cell Transplantation Adults

Frontiers in Immunology, 2019
Background: Recent studies of human sera showed that the majority of the respiratory syncytial virus (RSV) neutralizing antibodies are directed against pre-fusion conformation of the fusion (F) protein of RSV and revealed the importance of pre-fusion ...
Xunyan Ye, Obinna P. Iwuchukwu, Vasanthi Avadhanula, Letisha O. Aideyan, Trevor J. McBride, Laura L. Ferlic-Stark, Kirtida D. Patel, Felipe-Andres Piedra, Dimpy P. Shah, Roy F. Chemaly, Pedro A. Piedra, Pedro A. Piedra   +11 more
doaj   +1 more source

Respiratory Syncytial Virus Fusion Protein Promotes TLR-4–Dependent Neutrophil Extracellular Trap Formation by Human Neutrophils

PLoS ONE, 2015
Acute viral bronchiolitis by Respiratory Syncytial Virus (RSV) is the most common respiratory illness in children in the first year of life. RSV bronchiolitis generates large numbers of hospitalizations and an important burden to health systems ...
Giselle A. Funchal, N. Jaeger, R. Czepielewski, M. S. Machado, S. Muraro, R. Stein, C. Bonorino, B. Porto   +7 more
semanticscholar   +1 more source

Crystallization of the oligopeptide-binding protein AppA from Bacillus subtilis [PDF]

, 2004
AppA is the membrane-anchored extracellular receptor component of an ABC transporter responsible for the uptake of oligopeptides into Bacillus subtilis.
Blagova, E, Brannigan, J A, Chambers, J, Levdikov, V M, Pattenden, R J, Wilkinson, A J, Wright, L   +6 more
core   +1 more source

Mitochondrial Fusion Proteins and Human Diseases [PDF]

Neurology Research International, 2013
Mitochondria are highly dynamic, complex organelles that continuously alter their shape, ranging between two opposite processes, fission and fusion, in response to several stimuli and the metabolic demands of the cell. Alterations in mitochondrial dynamics due to mutations in proteins involved in the fusion-fission machinery represent an important ...
M. Ranieri, S. Brajkovic, G. Riboldi, D. Ronchi, F. Rizzo, N. Bresolin, S. Corti, G.P. Comi   +7 more
openaire   +5 more sources

The generation of Turnip crinkle virus-like particles in plants by the transient expression of wild-type and modified forms of its coat protein

Frontiers in Plant Science, 2015
Turnip crinkle virus (TCV), a member of the genus carmovirus of the Tombusviridae family, has a genome consisting of a single positive-sense RNA molecule that is encapsidated in an icosahedral particle composed of 180 copies of a single type of coat ...
Keith eSaunders, George Peter Lomonossoff   +1 more
doaj   +1 more source

Efficient Expression of Soluble Recombinant Protein Fused with Core-Streptavidin in Bacterial Strain with T7 Expression System

Methods and Protocols, 2020
The limited amount of fusion protein transported into cytosol milieu has made it challenging to obtain a sufficient amount for further applications. To avoid the laborious and expensive task, T7 promoter-driving pET-30a(+) coding for chimeric gene of ...
Ammar Tarar, Esmael M. Alyami, Ching-An Peng   +2 more
doaj   +1 more source

Production of Circularly Permuted Caspase-2 for Affinity Fusion-Tag Removal: Cloning, Expression in Escherichia coli, Purification, and Characterization

Biomolecules, 2020
Caspase-2 is the most specific protease of all caspases and therefore highly suitable as tag removal enzyme creating an authentic N-terminus of overexpressed tagged proteins of interest.
Monika Cserjan-Puschmann, Nico Lingg, Petra Engele, Christina Kröß, Julian Loibl, Andreas Fischer, Florian Bacher, Anna-Carina Frank, Christoph Öhlknecht, Cécile Brocard, Chris Oostenbrink, Matthias Berkemeyer, Rainer Schneider, Gerald Striedner, Alois Jungbauer   +14 more
doaj   +1 more source

Informational lesions: optical perturbation of spike timing and neural synchrony via microbial opsin gene fusions

Frontiers in Molecular Neuroscience, 2009
Synchronous neural activity occurs throughout the brain in association with normal and pathological brain functions. Despite theoretical work exploring how such neural coordination might facilitate neural computation and be corrupted in disease states ...
Xue Han, Xue Han, Xue Han, Xiaofeng Qian, Xiaofeng Qian, Patrick Stern, Amy Chuong, Edward S Boyden, Edward S Boyden, Edward S Boyden, Edward S Boyden   +10 more
doaj   +1 more source