Results 61 to 70 of about 7,427,824 (408)

Melittin-MIL-2 fusion protein as a candidate for cancer immunotherapy

Journal of Translational Medicine, 2016
BackgroundCytokine fusion protein that modulates the immune response holds great potential for cancer immunotherapy. IL-2 is an effective treatment against advanced cancers. However, the therapeutic efficacy of IL-2 is limited by severe systemic toxicity.
Mingjun Liu, Hai-tao Wang, Linjie Liu, Bin Wang, Guirong Sun   +4 more
semanticscholar   +1 more source

Production of Circularly Permuted Caspase-2 for Affinity Fusion-Tag Removal: Cloning, Expression in Escherichia coli, Purification, and Characterization

Biomolecules, 2020
Caspase-2 is the most specific protease of all caspases and therefore highly suitable as tag removal enzyme creating an authentic N-terminus of overexpressed tagged proteins of interest.
Monika Cserjan-Puschmann, Nico Lingg, Petra Engele, Christina Kröß, Julian Loibl, Andreas Fischer, Florian Bacher, Anna-Carina Frank, Christoph Öhlknecht, Cécile Brocard, Chris Oostenbrink, Matthias Berkemeyer, Rainer Schneider, Gerald Striedner, Alois Jungbauer   +14 more
doaj   +1 more source

Targeted delivery of autoantigen to dendritic cells prevents development of spontaneous uveitis

Frontiers in Immunology, 2023
Restoration of immunological tolerance to self antigens has been a major drive in understanding the mechanisms of, and developing new treatments for, autoimmune and autoinflammatory disease.
Izabela P. Klaska, Tian Yu, Tian Yu, Rosie Fordyce, Koju Kamoi, Koju Kamoi, Richard J. Cornall, Cristina Martin-Granados, Lucia Kuffova, Lucia Kuffova, John V. Forrester   +10 more
doaj   +1 more source

Domain interactions within Fzo1 oligomers are essential for mitochondrial fusion [PDF]

, 2006
Mitofusins are conserved GTPases essential for the fusion of mitochondria. These mitochondrial outer membrane proteins contain a GTPase domain and two or three regions with hydrophobic heptad repeats, but little is known about how these domains interact ...
Chan, David C., Griffin, Erik E.
core   +3 more sources

Arabidopsis HAP2/GCS1 is a gamete fusion protein homologous to somatic and viral fusogens

bioRxiv, 2016
Cell-cell fusion is inherent to any form of sexual reproduction. Loss of HAPLESS 2/GENERATIVE CELL SPECIFIC 1 (HAP2/GCS1) proteins results in gamete fusion failure in different organisms but their exact role is unclear. Here we show that Arabidopsis HAP2/
C. Valansi, D. Moi, E. Leikina, E. Matveev, M. Graña, L. Chernomordik, Héctor Romero, P. Aguilar, B. Podbilewicz   +8 more
semanticscholar   +1 more source

Mitochondrial Fusion Proteins and Human Diseases [PDF]

Neurology Research International, 2013
Mitochondria are highly dynamic, complex organelles that continuously alter their shape, ranging between two opposite processes, fission and fusion, in response to several stimuli and the metabolic demands of the cell. Alterations in mitochondrial dynamics due to mutations in proteins involved in the fusion-fission machinery represent an important ...
M. Ranieri, S. Brajkovic, G. Riboldi, D. Ronchi, F. Rizzo, N. Bresolin, S. Corti, G.P. Comi   +7 more
openaire   +5 more sources

Antigenic Site-Specific Competitive Antibody Responses to the Fusion Protein of Respiratory Syncytial Virus Were Associated With Viral Clearance in Hematopoietic Cell Transplantation Adults

Frontiers in Immunology, 2019
Background: Recent studies of human sera showed that the majority of the respiratory syncytial virus (RSV) neutralizing antibodies are directed against pre-fusion conformation of the fusion (F) protein of RSV and revealed the importance of pre-fusion ...
Xunyan Ye, Obinna P. Iwuchukwu, Vasanthi Avadhanula, Letisha O. Aideyan, Trevor J. McBride, Laura L. Ferlic-Stark, Kirtida D. Patel, Felipe-Andres Piedra, Dimpy P. Shah, Roy F. Chemaly, Pedro A. Piedra, Pedro A. Piedra   +11 more
doaj   +1 more source

Passaging of a Newcastle disease virus pigeon variant in chickens results in selection of viruses with mutations in the polymerase complex enhancing virus replication and virulence [PDF]

, 2010
Some Newcastle disease virus (NDV) variants isolated from pigeons (pigeon paramyxovirus type 1; PPMV-1) do not show their full virulence potential for domestic chickens but may become virulent upon spread in these animals.
Dortmans, J.C.F.M., Koch, G., Peeters, B.P.H., Rottier, P.J.M.   +3 more
core   +2 more sources

Respiratory Syncytial Virus Fusion Protein Promotes TLR-4–Dependent Neutrophil Extracellular Trap Formation by Human Neutrophils

PLoS ONE, 2015
Acute viral bronchiolitis by Respiratory Syncytial Virus (RSV) is the most common respiratory illness in children in the first year of life. RSV bronchiolitis generates large numbers of hospitalizations and an important burden to health systems ...
Giselle A. Funchal, N. Jaeger, R. Czepielewski, M. S. Machado, S. Muraro, R. Stein, C. Bonorino, B. Porto   +7 more
semanticscholar   +1 more source

Functional implications of respiratory syncytial virus F sequence variability: a comparative analysis using contemporary RSV isolates

mSphere
Respiratory syncytial virus (RSV) remains a major global health issue. Therapeutic options are limited, but new prophylactics, all targeting the fusion (F) glycoprotein, were recently licensed.
Kim Stobbelaar, Lotte Jacobs, Francisco I. Serrano-Cano, Axelle Fransen, Winke Van der Gucht, Annemieke Smet, Benedicte Y. De Winter, Paul Cos, Winnok de Vos, Kim Van Hoorenbeeck, Stijn Verhulst, Peter L. Delputte   +11 more
doaj   +1 more source