Results 71 to 80 of about 1,121,449 (385)

iProStruct2D: Identifying protein structural classes by deep learning via 2D representations [PDF]

Expert Systems With Applications 2020, 142, (March), 113019, 2019
In this paper we address the problem of protein classification starting from a multi-view 2D representation of proteins. From each 3D protein structure, a large set of 2D projections is generated using the protein visualization software Jmol. This set of multi-view 2D representations includes 13 different types of protein visualizations that emphasize ...
arxiv   +1 more source

Hendra virus fusion protein transmembrane domain contributes to pre-fusion protein stability [PDF]

Journal of Biological Chemistry, 2017
Enveloped viruses utilize fusion (F) proteins studding the surface of the virus to facilitate membrane fusion with a target cell membrane. Fusion of the viral envelope with a cellular membrane is required for release of viral genomic material, so the virus can ultimately reproduce and spread.
Stacy R. Webb, Rebecca Ellis Dutch, Tamas L. Nagy, Michael Fried, Hunter N. B. Moseley   +4 more
openaire   +3 more sources

Insights into the renal pathophysiology in Hermansky‐Pudlak syndrome‐1 from urinary extracellular vesicle proteomics and a new mouse model

FEBS Letters, Volume 599, Issue 7, Page 1055-1074, April 2025.
Hermansky‐Pudlak syndrome type 1 (HPS‐1) is a rare, autosomal recessive disorder with poorly understood renal involvement. Urinary extracellular vesicle (uEV) proteomics and a novel Hps1 mouse model reveal mitochondrial abnormalities and lipid accumulation in HPS‐1 kidney proximal tubule cells. Serum ApoA1 correlates with kidney function in our patient
Dawn M. Maynard, Bernadette R. Gochuico, Hadass Pri Chen, Christopher K. E. Bleck, Patricia M. Zerfas, Wendy J. Introne, William A. Gahl, May C. V. Malicdan   +7 more
wiley   +1 more source

Oral Immunization With a Plant HSP90-SAG1 Fusion Protein Produced in Tobacco Elicits Strong Immune Responses and Reduces Cyst Number and Clinical Signs of Toxoplasmosis in Mice

Frontiers in Plant Science, 2021
Plant 90kDa heat shock protein (HSP90) is a potent adjuvant that increases both humoral and cellular immune responses to diverse proteins and peptides.
Edwin F. Sánchez-López, Mariana G. Corigliano, Sonia Oliferuk, Victor A. Ramos-Duarte, Maximiliano Rivera, Luisa F. Mendoza-Morales, Sergio O. Angel, Valeria A. Sander, Marina Clemente   +8 more
doaj   +1 more source

Antibody Epitopes of Pneumovirus Fusion Proteins [PDF]

Frontiers in Immunology, 2019
The pneumoviruses respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) are two widespread human pathogens that can cause severe disease in the young, the elderly, and the immunocompromised. Despite the discovery of RSV over 60 years ago, and hMPV nearly 20 years ago, there are no approved vaccines for either virus.
Jiachen Huang, Jiachen Huang, Darren Diaz, Darren Diaz, Jarrod J. Mousa, Jarrod J. Mousa   +5 more
openaire   +4 more sources

Fusion pore conductance to determine the effects of mutating the structure of influenza virus hemagglutinin [PDF]

, 2016
Enveloped viruses, such as influenza, infect cells by fusing their viral envelope with the cell membrane. The fusion pore is a macromolecular structure that links two membranes that are fusing.
Wachter, Rebecca
core   +1 more source

Recombinant human preproinsulin expression, purification and reaction with insulin autoantibodies in sera from patients with insulin-dependent diabetes mellitus [PDF]

, 1993
A novel prokaryotic expression vector pGEX-6T was designed for high-level expression of recombinant fusion protein with a histidine-hexapeptide and glutathione-S-transferase at its N-terminus and the recombinant human preproinsulin at its C-terminus ...
Amman, Atkinson, Baekkeskov, Baekkeskov, Berthold, Boitard, Bottazzo, Castano, Dean, Frorath, Goedel, Greenbaum, Harrison, Heike Berg, Hopp, Jochen Seissler, Karjalainen, Kaufman, Kuglin, Kuglin, Ludwig Mauch, Michael Walter, Palmer, Patrick, Seissler, Smith, Smith, Snyder, Su, Wolfgang Northemann   +29 more
core   +1 more source

The [2Fe‐2S] cluster of mitochondrial outer membrane protein mitoNEET has an O2‐regulated nitric oxide access tunnel

FEBS Letters, Volume 599, Issue 7, Page 952-970, April 2025.
The mitochondrial outer membrane iron–sulphur ([Fe‐S]) protein mitoNEET is a target of the type‐2 diabetes drug pioglitazone. Its unknown molecular function is linked to respiratory complex activity and mitochondrial function. We discovered that O2 protects the mitoNEET [2Fe‐2S] cluster against NO oxidation and desensitization towards reduction by H2S.
Thao Nghi Hoang, Meritxell Wu‐Lu, Alberto Collauto, Peter‐Leon Hagedoorn, Madalina Alexandru, Maike Henschel, Shahram Kordasti, Maria Andrea Mroginski, Maxie M. Roessler, Kourosh H. Ebrahimi   +9 more
wiley   +1 more source

Functional and evolutional implications of natural channel-enzyme fusion proteins

Biomolecular Concepts, 2011
Channeling of ions or substrates across membranes and enzymatic activity are two highly distinct biochemical concepts. They are usually studied by different research groups, which focus on either subject.
Song Jie, Wu Binghua, Beitz Eric
doaj   +1 more source

Interferon-induced transmembrane protein 3 (IFITM3) and its antiviral activity [PDF]

arXiv, 2022
Enveloped viral infections require fusion with cellular membranes for viral genome entry, occurring only following interaction of viral and cellular membranes allowing fusion pore formation, by which the virus accesses the cytoplasm. Here, we focus on interferon-induced transmembrane protein 3 (IFITM3) and its antiviral activity. IFITM3 is predicted to
arxiv