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The silent players: Atypical <i>BCR‑ABL </i>isoforms as biomarkers and therapeutic hurdles in CML pathogenesis (Review). [PDF]

Oncol Rep
Zhou X, Li A, Kong D, Shi Y, Zhang P, Shan N.   +5 more
europepmc   +1 more source

Flow cytometric immunobead assay for the detection of BCR–ABL fusion proteins in leukemia patients [PDF]

Leukemia, 2009
BCR-ABL fusion proteins show increased signaling through their ABL tyrosine kinase domain, which can be blocked by specific inhibitors, thereby providing effective treatment. This makes detection of BCR-ABL aberrations of utmost importance for diagnosis, classification and treatment of leukemia patients.
P Lucio, Łukasz Sedek, Tomasz Szczepanski   +2 more
exaly   +7 more sources

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An immunological method for the detection of BCR-ABL fusion protein and monitoring its activation

Leukemia Research, 2008
We have developed a simplified sandwich immunoassay to measure free circulating total and phosphorylated fusion BCR-ABL protein in patients with the t(9;22)(q34;q11) chromosomal translocation. The assay is based on immunoprecipitating BCR-ABL protein using beads coated with anti-BCR antibody and detecting the fusion protein with anti-ABL antibody and ...
Iman Jilani, Hagop Kantarjian, Oliver G Ottmann   +2 more
exaly   +3 more sources

Targeting the Kinase Activity of the BCR-ABL Fusion Protein in Patients with Chronic Myeloid Leukemia

Current Molecular Medicine, 2005
Imatinib mesylate is a major advance in the therapy of patients with chronic myelogenous leukemia (CML). Imatinib mesylate binds to the inactive conformation of BCR-ABL tyrosine kinase suppressing the Philadelphia chromosome positive clone in CML. Clinical studies have yielded impressive results in all phases of CML.
Francis J, Giles, Jorge E, Cortes, Hagop M, Kantarjian   +2 more
openaire   +2 more sources

Detection of BCR-ABL fusion proteins in patients with leukemia using a cytometric bead array

Leukemia & Lymphoma, 2011
Rapid and accurate detection of BCR-ABL fusion proteins is vital for the diagnosis and classification of leukemias, especially chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL). Recently, the cytometric bead array (CBA) system has been used to identify BCR-ABL proteins in leukemic cell lysates.
Wu, Yujie, Zhu, Yu, Qian, Sixuan, Wang, Li, Liu, Peng, Ge, Zeng, Zhang, Sujiang, Li, Jianyong   +7 more
openaire   +2 more sources

Nuclear topography and expression of the BCR/ABL fusion gene and its protein level influenced by cell differentiation and RNA interference

Leukemia Research, 2005
Nuclear topography, expression of the BCR/ABL fusion gene and its protein level/cellular pattern were studied in CML cell line K562 stimulated to differentiation, apoptosis and influenced by ABL-RNA interference (ABL-RNAi). Phorbol ester-induced maturation of K562 cells was accompanied by repositioning of down-regulated BCR/ABL genes closer to the ...
Eva Bártová, Andrea Harničárová, Jiří Pacherník   +2 more
exaly   +3 more sources

Flow Cytometry Detection of BCR-ABL Fusion Proteins in Leukemia Patients- An Indian Experience.

Blood, 2009
Abstract Abstract 4710 Background The BCR-ABL fusion gene results from the translocation t(9;22). It is the hallmark of chronic myeloid leukemia (CML) and is present in a poor risk subgroup of precursor B cell Acute Lymphoblastic Leukemia(ALL),which represents 25 to 30% of adult ALL and
Soma Mukhopadhyay, Ujjal Kanti Roy, Ritwik Pandey, Pinaki Gupta, Jayasri Basak, Sanjay Sarkar, Ashis Mukhopadhyay, Haemato   +6 more
openaire   +1 more source

Differential signaling through p190 and p210 BCR-ABL fusion proteins revealed by interactome and phosphoproteome analysis

Leukemia, 2017
Two major types of leukemogenic BCR-ABL fusion proteins are p190BCR-ABLand p210BCR-ABL. Although the two fusion proteins are closely related, they can lead to different clinical outcomes. A thorough understanding of the signaling programs employed by these two fusion proteins is necessary to explain these clinical differences.
J A, Cutler, R, Tahir, S K, Sreenivasamurthy, C, Mitchell, S, Renuse, R S, Nirujogi, A H, Patil, M, Heydarian, X, Wong, X, Wu, T-C, Huang, M-S, Kim, K L, Reddy, A, Pandey   +13 more
openaire   +2 more sources