Results 141 to 150 of about 11,258 (167)

Measurement of Free Circulating Bcr-Abl Fusion Protein and Its Phosphorylation in Patients with Chronic Myeloid Leukemia.

Blood, 2005
Abstract Diagnosis and monitoring of therapy in chronic myeloid leukemia (CML) depend on cytogenetic, FISH, and PCR assays for detecting the fusion bcr-abl gene. However, the there is an inherent variability and difficulty in standardizing quantitative PCR-based assays.
I. Jilani, H. Kantarjian, H. Faraji, M. Gorre, J. Cortes, O. Ottmann, K. Bhalla, S. O’Brien, F. Giles, M. Albitar   +9 more
openaire   +1 more source

Flow cytometric bead assay of BCR-ABL fusion proteins in leukemia patients: An Indian experience.

Journal of Clinical Oncology, 2010
6595 Background: The BCR-ABL fusion gene results from the translocation t(9;22). It is the hallmark of chronic myeloid leukemia (CML) and is present in a poor-risk subgroup of precursor B cell acut...
openaire   +1 more source

[Construction and expression of a vector containing protein transduction domain and bcr/abl fusion gene].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, 2002
To construct a vector containing protein transduction domain (PTD) and bcr/abl fusion gene of chronic myelogenous leukemia and express PTD-bcr/abl fusion protein in E. Coli.DNA fragment encoding PTD was synthesized and fused to PCR-amplified bcr/abl gene fragment, then inserted into plasmid pET-16b to get the expression vector pEPb containing PTD-bcr ...
Yingmin, Liang, Qiang, Sun, Shanshan, Jiang, Jizhu, Wang, Rongli, Wu, Ping, Chen, Li, Liu, Hua, Han   +7 more
openaire   +1 more source

Flow cytometric immunobead assay for the detection of BCR-ABL fusion proteins in leukemia patients

2012
Peer ...
Weerkamp, F., Flores-Montero, Juan, Orfao, Alberto   +2 more
openaire   +1 more source

Detection and significance of bcr-abl mRNA transcripts and fusion proteins in Philadelphia-positive adult acute lymphoblastic leukemia.

Leukemia, 1993
Blast cells from an unselected consecutive series of 84 adults presenting with acute lymphoblastic leukemia (ALL) to St Bartholomew's Hospital over a seven year period were tested prospectively by cytogenetic and retrospectively by RT-PCR analysis for the presence of the Ph translocation and bcr-abl mRNA. This combination gave an overall figure of 20.3%
A, Tuszynski, S, Dhut, B D, Young, T A, Lister, A Z, Rohatiner, J A, Amess, T, Chaplin, E, Dorey, B, Gibbons   +8 more
openaire   +1 more source

A novel fusion circular RNA F-circBA1 derived from the BCR-ABL fusion gene displayed an oncogenic role in chronic myeloid leukemia cells

Bioengineered, 2021
Wenli Feng, Zhenglan Huang
exaly  

Establishment and molecular characterization of a novel leukemic cell line with Philadelphia chromosome expressing p230 BCR/ABL fusion protein.

Cancer research, 1995
The cell line AR230 was established from the peripheral blood mononuclear cells of a patient with chronic myeloid leukemia and t(9;22) translocation bearing a variant type of BCR/ABL rearrangement. AR230 expresses a BCR/ABL fusion protein with a molecular mass of 230 kilodaltons (kDa) due to the insertion of 180 amino acids encoded by 3' exons of BCR ...
H, Wada, S, Mizutani, J, Nishimura, Y, Usuki, M, Kohsaki, M, Komai, H, Kaneko, S, Sakamoto, D, Delia, A, Kanamaru   +9 more
openaire   +1 more source

CeO2/MXene heterojunction-based ultrasensitive electrochemiluminescence biosensing for BCR-ABL fusion gene detection combined with dual-toehold strand displacement reaction for signal amplification

Biosensors and Bioelectronics, 2022
Min Zhao, Wei Cheng, Yongjie Xu
exaly  

Two bcr/abl fusion gene products, P210bcr/abl and P190bcr/abl, are equally sensitive to the protein tyrosine phosphatase of mature granulocytes.

International journal of hematology, 1992
Two bcr/abl fusion gene products with tyrosine kinase activity have been found in two phenotypes of Philadelphia chromosome (Ph1)-positive leukemia. P210bcr/abl (P210) is associated with Ph1-positive chronic myelogenous leukemia (CML), while P190bcr/abl is associated with Ph1-positive acute leukemia.
J, Nishimura, J, Okamura, K, Shibata, H, Takahira, Y, Yufu, S, Kato, J, Hirata, T, Umemura, H, Nawata   +8 more
openaire   +1 more source

[Signal transduction BCR-ABL fusion protein: analysis of BCR-ABL functional domains].

[Rinsho ketsueki] The Japanese journal of clinical hematology, 1998
T, Tauchi, S, Okabe, K, Oyashiki, K, Sotoyama   +3 more
openaire   +1 more source