Results 151 to 160 of about 11,727 (181)

[Preparation and identification of rabbit polyclonal antibody against BCR-ABL b3a2 fusion protein].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2021
Objective To prepare and identify rabbit anti-breakpoint cluster region-Abelson leukemia virus oncogene (BCR-ABL) b3a2 subtype polyclonal antibody. Methods A peptide containing the fusion sequence of the b3a2 subtype BCR-ABL fusion protein was designed and synthesized with the purity higher than 90%. The fusion polypeptide was coupled to Keyhole Limpet
Xiangning, Li, Jiayao, Qu, Jing, Jiang, Li, Wang, Dixian, Luo, Jia, Li, Lili, Duan, Rongzhang, He, Zheng, Hu   +8 more
openaire   +1 more source

TAT-CC fusion protein depresses the oncogenicity of BCR-ABL in vitro and in vivo through interrupting its oligomerization

Amino Acids, 2012
Chronic myeloid leukemia (CML) is a clonal hematologic malignancy characterized by the BCR-ABL protein. BCR-ABL is a constitutively active tyrosine kinase and plays a critical role in the pathogenesis of CML. Imatinib mesylate, a selective tyrosine kinase inhibitor, is effective in CML, but drug resistance and relapse occur. The coiled-coil (CC) domain
Zheng-Lan, Huang, Miao, Gao, Mao-Sheng, Ji, Kun, Tao, Qing, Xiao, Liang, Zhong, Jian-Ming, Zeng, Wen-Li, Feng   +7 more
openaire   +2 more sources

Immunologic Evaluation of Peptides Derived From BCR/ABL-Out-of-Frame Fusion Protein in HLA A2.1 Transgenic Mice

Journal of Immunotherapy, 2012
Philadelphia chromosome-positive chronic myelogenous leukemia and acute lymphocytic leukemia express, besides the main BCR/ABL transcripts, novel BCR/ABL transcripts derived from alternative splicing between BCR exons 1, 13, or 14 with ABL exons 4 and 5. Their translational products present at C-terminus an amino acid portion derived from out-of-frame (
C. Casnici, G. Volpe, K. Crotta, D. Lattuada, G. Saglio, O. Marelli   +5 more
openaire   +2 more sources

Comparative Study of Molecular Interactions of Thymol and Imatinib with BCR-ABL Fusion Protein In-Silico for the Selective Anti-CML Activity of Thymol

CARDIOMETRY, 2023
Aim: To study the comparative molecular interactions of Thymol and Imatinib with the active sites of Breakpoint Cluster Region (BCR)-Abelson (ABL) fusion protein using molecular docking analysis for the selective anti-Chronic myeloid leukemia (CML) activity.
R.M.R. Charan, D. Lokesh
openaire   +1 more source

Measurement of Free Circulating Bcr-Abl Fusion Protein and Its Phosphorylation in Patients with Chronic Myeloid Leukemia.

Blood, 2005
Abstract Diagnosis and monitoring of therapy in chronic myeloid leukemia (CML) depend on cytogenetic, FISH, and PCR assays for detecting the fusion bcr-abl gene. However, the there is an inherent variability and difficulty in standardizing quantitative PCR-based assays.
I. Jilani, H. Kantarjian, H. Faraji, M. Gorre, J. Cortes, O. Ottmann, K. Bhalla, S. O’Brien, F. Giles, M. Albitar   +9 more
openaire   +1 more source

Comparative Study of Molecular Interaction of Quercetin and Imatinib with BCR-ABL Fusion Protein In-Silico for the Selective Anti-CML Activity of Quercetin

CARDIOMETRY, 2023
Aim: To study the comparative molecular interactions of Quercetin and Imatinib with the active sites of Breakpoint Cluster Region (BCR)-Abelson (ABL) fusion protein using molecular docking analysis for the selective anti-Chronic myeloid leukemia (CML) activity.
R.M.R. Charan, G. Reddypriya
openaire   +1 more source

Flow cytometric bead assay of BCR-ABL fusion proteins in leukemia patients: An Indian experience.

Journal of Clinical Oncology, 2010
6595 Background: The BCR-ABL fusion gene results from the translocation t(9;22). It is the hallmark of chronic myeloid leukemia (CML) and is present in a poor-risk subgroup of precursor B cell acut...
openaire   +1 more source

[Construction and expression of a vector containing protein transduction domain and bcr/abl fusion gene].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, 2002
To construct a vector containing protein transduction domain (PTD) and bcr/abl fusion gene of chronic myelogenous leukemia and express PTD-bcr/abl fusion protein in E. Coli.DNA fragment encoding PTD was synthesized and fused to PCR-amplified bcr/abl gene fragment, then inserted into plasmid pET-16b to get the expression vector pEPb containing PTD-bcr ...
Yingmin, Liang, Qiang, Sun, Shanshan, Jiang, Jizhu, Wang, Rongli, Wu, Ping, Chen, Li, Liu, Hua, Han   +7 more
openaire   +1 more source

Detection and significance of bcr-abl mRNA transcripts and fusion proteins in Philadelphia-positive adult acute lymphoblastic leukemia.

Leukemia, 1993
Blast cells from an unselected consecutive series of 84 adults presenting with acute lymphoblastic leukemia (ALL) to St Bartholomew's Hospital over a seven year period were tested prospectively by cytogenetic and retrospectively by RT-PCR analysis for the presence of the Ph translocation and bcr-abl mRNA. This combination gave an overall figure of 20.3%
A, Tuszynski, S, Dhut, B D, Young, T A, Lister, A Z, Rohatiner, J A, Amess, T, Chaplin, E, Dorey, B, Gibbons   +8 more
openaire   +1 more source

A novel fusion circular RNA F-circBA1 derived from the BCR-ABL fusion gene displayed an oncogenic role in chronic myeloid leukemia cells

Bioengineered, 2021
Zhenglan Huang, Guoyun Jiang, Wenli Feng   +2 more
exaly