Results 281 to 290 of about 1,010,581 (327)

The combination of Mycobacterium tuberculosis fusion proteins LT33 and LT28 induced strong protective immunity in mice. [PDF]

Front Immunol
He P, Wang J, Tan D, Hu L, Ma Y, Mi Y, Li F, Zhang T, Du Y, Zhang W, Li J, Jiao L, Zhu B.   +12 more
europepmc   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Adaptive immunity of type VI CRISPR-Cas systems associated with reverse transcriptase-Cas1 fusion proteins. [PDF]

Nucleic Acids Res
Molina-Sánchez MD, Martínez-Abarca F, Millán V, Mestre MR, Stehantsev P, Stetsenko A, Guskov A, Toro N.   +7 more
europepmc   +1 more source

TFE3 fusion proteins promote the progression of TFE3 rearranged renal cell carcinoma via enhancing chaperone-mediated lipophagy. [PDF]

Cell Commun Signal
Ma W, Chen Y, Chen G, Yang L, Lu Y, Dong X, Li D, Gan W.   +7 more
europepmc   +1 more source

Nanoparticle-formulated mRNA encoding engineered multivalent SIRPα-Fc fusion proteins shows robust anti-cancer activity in preclinical models. [PDF]

Mol Ther Nucleic Acids
Lal S, Sallets A, Bandi SR, Adusumilli G, Liu W, Low R, Ferry K, MacDonough C, ElAzzouny M, Haabeth OAW, McKinlay CJ, Hsu PK, Sharma A, Dhungel P, Triplett J, Leong M, McCartney-Melstad E, Deutsch S, Gunasekaran K.   +18 more
europepmc   +1 more source

Design and antiviral assessment of a panel of fusion proteins targeting human papillomavirus type 16. [PDF]

PLoS One
Bai C, Bai C, Wang R, Yang Q, Hao J, Zhong Q, Fan R, Han P.   +7 more
europepmc   +1 more source

FusionPDB: a knowledgebase of human fusion proteins. [PDF]

Nucleic Acids Res
Kumar H, Tang LY, Yang C, Kim P.
europepmc   +1 more source

The APL-associated fusion proteins.

Haematologica, 1999
S. Minucci, M. Cioce, M. Maccarana, P. G. Pelicci   +3 more
openaire   +2 more sources

NPM1-fusion proteins promote myeloid leukemogenesis through XPO1-dependent HOX activation. [PDF]

Leukemia
Shimosato Y, Yamamoto K, Jia Y, Zhang W, Shiba N, Hayashi Y, Ito S, Kitamura T, Goyama S.   +8 more
europepmc   +1 more source

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Therapeutic Fusion Proteins

The AAPS Journal, 2023
Therapeutic fusion proteins are a class of hybrid constructs that combine distinct biomolecules into a single platform with the additive effects of the components. The ability to fuse two unrelated proteins provides a means to localize mechanisms to better treat a range of diseases. Fusion proteins can be designed to impart diverse functions, including
Morgan C. Marsh, Shawn C. Owen
openaire   +2 more sources