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Fusion of classifiers for predicting protein–protein interactions

Neurocomputing, 2005
Prediction of protein-protein interaction is a difficult and an important problem in biology. In this paper, we describe a very general method for predicting protein-protein interactions. The interaction mining approach is demonstrated by building a learning system based on experimentally validated protein-protein interactions in the human gastric ...
openaire   +2 more sources

Fusion protein with a toxin and scaffold protein

2020
The present invention relates to the field of structural biology and drug discovery. More specifically, the present invention relates to novel fusion proteins, their uses and methods in three-dimensional structural analysis of macromolecules, such as X-ray crystallography and high-resolution Cryo-EM, and their use in structure-based drug design and ...
Steyaert, Jan, Pardon, Els, Vranken, Wim
openaire   +2 more sources

Design of fusion proteins for biocatalysis

The use of enzymes to convert substrates into valuable products has been an integral part of biocatalysis. However, some reactions are energy-demanding that requires the use of NAD(P)H to proceed. This NAD(P)H can be costly impeding the progress of enzyme usage at a bigger scale.
Beyzanur, Celebi   +3 more
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Mapping protein-protein interactions with alkaline phosphatase fusion proteins

2001
Publisher Summary This chapter describes a convenient and versatile method for determining the molecular recognition properties of SH3 domains, using bacterial alkaline phosphatase as a fusion protein. A variety of proteins or peptides have been fused to the N terminus of alkaline phosphatase (AP) by genetic engineering, including antibody chains and
Brian K. Kay, Montarop Yamabhai
openaire   +3 more sources

Nanooncology: The future of cancer diagnosis and therapy

Ca-A Cancer Journal for Clinicians, 2013
Avnesh S Thakor
exaly  

Translating cancer genomes and transcriptomes for precision oncology

Ca-A Cancer Journal for Clinicians, 2016
Sameek Roychowdhury, Arul M Chinnaiyan
exaly  

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