Results 91 to 100 of about 13,524,575 (343)

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Multi-index Fusion Prediction at Various Stages for Coal Spontaneous Combustion

Chemical Engineering Transactions, 2018
Coal spontaneous combustion fire seriously threatens the safety of mine production. How to improve the prediction accuracy of coal spontaneous combustion is a hot topic in current research.
Jiantao Wang, Fusheng Wang, Yunyun Xu, Xinran Hou, Xianwei Dong   +4 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Deep-Learning Spatial and Temporal Fusion Model for Land Surface Temperature Based on a Spatially Adaptive Feature and Temperature-Adaptive Correction Module

Remote Sensing
Land surface temperature (LST) is essential for studying land–atmosphere energy exchange, the impact of climate change, and its influence on crop yields and hydrology.
Chenhao Jin, Jiasheng Li, Yao Shen
doaj   +1 more source

In situ thermography for laser powder bed fusion: Effects of layer temperature on porosity, microstructure and mechanical properties

, 2019
In laser powder bed fusion (LPBF) the surface layer temperature is continually changing throughout the build process. Variations in part geometry, scanned cross-section and number of parts all influence the thermal field within a build.
Richard J. Williams, Alessandro Piglione, T. Ronneberg, Connor Jones, M. Pham, C. Davies, P. Hooper   +6 more
semanticscholar   +1 more source

Ontological representation of context knowledge for visual data fusion [PDF]

, 2009
8 pages, 4 figures.-- Contributed to: 12th International Conference on Information Fusion, 2009 (FUSION '09, Seattle, Washington, US, Jul 6-9, 2009).Context knowledge is essential to achieve successful information fusion, especially at high JDL levels ...
Molina, José M., Gómez Romero, Juan, Patricio Guisado, Miguel Ángel, García, Jesús   +3 more
core   +3 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Fusion Blankets and Fluoride-Salt-Cooled High-Temperature Reactors with Flibe Salt Coolant: Common Challenges, Tritium Control, and Opportunities for Synergistic Development Strategies Between Fission, Fusion, and Solar Salt Technologies

Nuclear Technology, 2019
Recent developments in high-magnetic-field fusion systems have created large incentives to develop flibe (Li2BeF4) salt fusion blankets that have four functions: (1) convert the high energy of fusion neutrons into heat for the power system, (2) convert ...
C. Forsberg, G. Zheng, R. Ballinger, Stephen T. Lam   +3 more
semanticscholar   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source