Results 101 to 110 of about 13,524,575 (343)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Pixel Level Image Fusion using Fuzzylet Fusion Algorithm [PDF]

, 2013
Image fusion algorithms based on SWT (Stationary Wavelet Transform) and fuzzy logic were developed and demonstrated. It was observed that fusion using SWT with higher levels of decomposition provides better fusion results. Similarly, Fuzzy image fusion
Bindu, Elias, Naidu, VPS, Swathi, Nair
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

A Deep Learning-Based Fusion Framework for Temperature-Aware Relative Humidity Sensing Using Dual Fiber-Optic Sensors

IEEE Access
This work presents a fiber-optic sensor fusion framework for temperature-aware relative humidity sensing. The proposed system integrates a micro-loop resonator (MLR) coated with hydroxyethyl cellulose/poly(vinylidene fluoride) (HEC/PVDF) and a D-shaped ...
Huda Adnan Zain, Khurram Karim Qureshi
doaj   +1 more source

Small, modular and economically attractive fusion enabled by high temperature superconductors

Philosophical Transactions of the Royal Society A, 2019
The advantages of high magnetic fields in tokamaks are reviewed, and why they are important in leading to more compact tokamaks. A brief explanation is given of what limits the magnetic field in a tokamak, and why high temperature superconductors (HTSs ...
D. Whyte
semanticscholar   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Heat of Fusion of Na3AlF6 Eutectic Mixtures with CaF2 and Al2O3

Chimica Techno Acta, 2019
The heat of fusion of eutectic mixtures of sodium cryolite with alumina and calcium fluoride was measured using differential scanning calorimetry. Melting temperatures were found to be in good agreement with literature data.
Alexander A. Redkin, Svetlana V. Pershina, Evgenia A. Il'ina, Alexander A. Kataev, Yurii P. Zaikov   +4 more
doaj   +1 more source

An Archival Study on the Fusion Researches in Japan from 1965 to 1986 An Interview with Sekiguchi Tadashi [PDF]

, 2001
We here report an archival study undertaken by the method of an interview with Sekiguchi Tadashi, Professor Emeritus at the University of Tokyo. The theme covers the circumstances of the fusion research during the period (1965-1976) when fusion project ...
KAWAKAMI, Ichiro, KIMURA, Kazue, UEMATSU, Eisui, TAKAIWA, Yoshinobu, NISIO, Shigeko, OBAYASHI, Haruo, TAKEDA, Tatsuoki, NAMBA, Chusei, NISHIO, Shigeko, FUJITA, Junji, WAKATANI, Masahiro, TERASHIMA, Yoshinosuke   +11 more
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Real-time diagnosis of ion temperature by neutron yields in magnetic confinement fusion

Nuclear Fusion
In magnetic confinement fusion experiments, ion temperature is one of the key parameters affecting the fulfillment of Lawson’s criterion, the rate of reaction generation and the quality of confinement. Currently, the commonly used methods to diagnose ion
Xiaobin Li, Jie Zhang, Wei Chen, Liang Liu, Lei Feng, Zijia Zhao, Lichao Tian   +6 more
doaj   +1 more source