Results 81 to 90 of about 427,191 (267)

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Status and issues of high-temperature and high-pressure water corrosion research of fusion structural materials in Japanese DEMO reactor development

Nuclear Fusion
The activated corrosion product assessments of fusion structural materials are essential to designing components and evaluating workers’ radiation exposure.
Motoki Nakajima, Takashi Nozawa
doaj   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Temperature Compensation for MEMS Accelerometer Based on a Fusion Algorithm

Micromachines
This study proposes a fusion algorithm based on forward linear prediction (FLP) and particle swarm optimization–back propagation (PSO-BP) to compensate for the temperature drift. Firstly, the accelerometer signal is broken down into several intrinsic mode functions (IMFs) using variational modal decomposition (VMD); then, according to the FE algorithm,
Yangyanhao Guo, Zihan Zhang, Longkang Chang, Jingfeng Yu, Yanchao Ren, Kai Chen, Huiliang Cao, Huikai Xie   +7 more
openaire   +3 more sources

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Research on Heat Transfer Performance of Different Coolants for the First Wall of the Test Blanket Module of Nuclear Fusion Reactor

南方能源建设
[Introduction] As a clean and efficient energy source, nuclear fusion promises to achieve global sustainable development in the future. For the first wall of Chinese helium-cooled solid breeder test blanket module, the temperature fields of helium, argon
Haolei ZHANG, Tao ZHOU, Chunhui XUE, Peng LIU   +3 more
doaj   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Optimum Position of Room Temperature Sensor for Variable Air Volume Air-conditioning System

Zhileng xuebao, 2019
The temperature field of indoor space is non-uniform, and the temperature measurements at different locations are usually different. The thermostat is usually installed on the wall near the door in air-conditioned room, and the measured temperature does ...
Yan Xiuying, Zhai Zhiwei
doaj  

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source