Results 91 to 100 of about 37,797 (268)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Acerca de las normas en defensa de la competencia

Revista de la Facultad de Derecho, 2014
Contenido: Concepto de defensa de la competencia. Razones de la existencia de las normas de defensa de la competencia en el Uruguay. Definición de competencia. Derecho positivo vigente. Control previo de fusiones y adquisiciones.
Román Stebrich Chagas
doaj   +2 more sources

Comunicación interna y fusión de empresas: la necesidad de una planificación

Vivat Academia, 2012
Basándonos en el conocimiento empírico de algunas consecuencias nefastas derivadas de la revolución del 25 de Abril de 1974 en Portugal, intentamos analizar los resultados de las fusiones a nivel de comunicación interna y del conjunto del clima interno ...
Anabela Ferreira Félix Mateus
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Fusiones y adquisiciones en la industria de tecnología: análisis bibliométrico y futuras vías de investigación

Revista de Estudios Empresariales. Segunda Época
El crecimiento de investigaciones en administración y dirección de empresas, la aceleración del cambio tecnológico y los procesos de consolidación empresarial a nivel global, han motivado la elaboración de este estudio sobre las fusiones y adquisiciones
Salomón M. Paucar Huacac
doaj   +1 more source

Métricas contables como factores críticos del desempeño financiero: Evidencia de fusiones y adquisiciones en México. (Accounting metrics as critical factors affecting financial performance: Evidence from M&A in Mexico) [PDF]

, 2015
. Mergers and acquisitions operationes in Mexico has been increasing in recent years. Literature´s opinion is divided among results on financial performance after the acquisition, there is evidence of gains and losses depending on several characteristics
Hinojosa Treviño, Sergio Raul, Méndez Sáenz, Alma Berenice   +1 more
core  

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

El camp como detonador de des-fusiones dramáticas: liberación y cinismo en la posmodernidad

Anales del Instituto de Investigaciones Estéticas
El presente trabajo tiene por objetivo pensar las expresiones de la sensibilidad camp como detonadoras de des-fusiones dramáticas. La des-fusión dramática, concepto introducido por Jeffrey Alexander, nos ayudará a medir los alcances de una sensibilidad ...
Alexa Rosales Rivera, Eleocadio Martínez Silva   +1 more
doaj   +1 more source