Results 111 to 120 of about 14,363 (250)

Monosegmental ALPPS after Bilateral Hepatectomy

Annals of Hepatology, 2017
Associated liver partition and portal vein ligation for staged hepatectomy (ALPPS) has emerged as an alternative for patients with bilobar colorectal liver metastasis and a small future liver remnant (FLR).
Klaus Steinbrück, Marcelo D’Oliveira, Renato Cano, Marcelo Enne   +3 more
doaj   +1 more source

Future liver remnant portal or hepatic vein reconstruction at stage I of ALPPS-How far can we push the boundaries? [PDF]

, 2019
Preservation of the future liver remnant (FLR) vascular integrity has always been considered crucial to achieving successful liver growths after major hepatectomies.
John Isaac, Isaac, John, Sakuraoka Y., Schlegel A., Coldham, Chris, Isaac J., Coldham C., Andrea Schlegel, Paolo Muiesan, Sakuraoka, Yuhki, Marit Kalisvaart, Muiesan, Paolo, Schlegel, Andrea, Muiesan P., Kalisvaart, Marit, Yuhki Sakuraoka, Chris Coldham, Kalisvaart M.   +17 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Safety and outcomes of pre-operative portal vein embolization using N-butyl cyanoacrylate (Glue) in hepatobiliary malignancies: A single center retrospective analysis

Indian Journal of Radiology and Imaging, 2019
Aims and Objectives: To evaluate the outcome of preoperative portal vein embolization (PVE) using N-butyl cyanoacrylate (NBCA) for change in future liver remnant (FLR) volume, biochemical changes, and procedure-related complications.
Amar Mukund, Aniket Mondal, Yashwant Patidar, Senthil Kumar   +3 more
doaj   +1 more source

Can plasma bile salt, triglycerides, and apoA-V levels predict liver regeneration? [PDF]

, 2012
BACKGROUND: Preoperative portal vein embolization (PVE) is used to increase the future remnant liver (FRL) in patients requiring extensive liver resection.
van Gulik, T.M., Bennink, Roel J., Chamuleau, R.A., Hoekstra, L. T., Bennink, R. J., van Lienden, K. P., Schaap, F.G., Hoekstra, Lisette T., van Lienden, Krijn P., Schaap, Frank G., Chamuleau, Rob A. F. M., van Gulik, Thomas M.   +11 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Portal vein embolization for induction of selective hepatic hypertrophy prior to major hepatectomy: rationale, techniques, outcomes and future directions

Cancer Biology & Medicine, 2016
The ability to modulate the future liver remnant (FLR) is a key component of modern oncologic hepatobiliary surgery practice and has extended surgical candidacy for patients who may have been previously thought unable to survive liver resection. Multiple
David Li, David C. Madoff
doaj   +1 more source

Future remnant liver function estimated by combining liver volumetry on magnetic resonance imaging with total liver function on ^{99m}Tc$-mebrofenin hepatobiliary scintigraphy : can this tool predict post-hepatectomy liver failure? [PDF]

, 2016
: Introduction: Posthepatectomy liver failure (PHLF) is a major complication after hepatectomy with a high mortality rate and is likely to happen in insufficient liver remnant. We hypothesize that assessment of the estimated future liver remnant function
Huyghe, Ivan, Driessen, Ann, Ysebaert, Dirk, Chapelle, Thiery, De Greef, Kathleen, op de Beeck, Bart, Francque, Sven, Roeyen, Geert   +7 more
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Nonsuperiority of technetium-99m-galactosyl human serum albumin scintigraphy over conventional volumetry for assessing the future liver remnant in patients undergoing hepatectomy after portal vein embolization [PDF]

[Background] Technetium-99m-galactosyl human serum albumin scintigraphy is preferred for assessing the liver functional reserve in patients undergoing hepatectomy, but its superiority over computed tomography volumetry after portal vein embolization and ...
Ishii, Takamichi, Koyama, Yukinori, Shimizu, Hironori, 小木曾, 聡, Ogiso, Satoshi, 波多野, 悦朗, Hatano, Etsuro, Taura, Kojiro, Nishio, Takahiro, 瀬尾, 智, 西尾, 太宏, 清水, 大功, 石井, 隆道, 楊, 知明, Hata, Koichiro, 秦, 浩一郎, Ishimori, Takayoshi, Masui, Toshihiko, Fukumitsu, Ken, Yao, Siyuan, Okamoto, Tatsuya, 田浦, 康二朗, Seo, Satoru, Yoh, Tomoaki, 小山, 幸法, 岡本, 竜弥, 増井, 俊彦, 福光, 剣, 姚, 思遠   +28 more
core