Results 121 to 130 of about 14,363 (250)

Postoperative Mortality after Liver Resection for Perihilar Cholangiocarcinoma: Development of a Risk Score and Importance of Biliary Drainage of the Future Liver Remnant [PDF]

, 2016
Background: Liver surgery for perihilar cholangiocarcinoma (PHC) is associated with postoperative mortality ranging from 5% to 18%. The aim of this study was to develop a preoperative risk score for postoperative mortality after liver resection for PHC ...
Wiggers, J.K. (Jimme K.), Gulik, T.M. (Thomas) van, Besselink, Marc G., Cieslak, K.P. (Kasia P.), D'Angelica, M.I. (Michael I.), Gulik, TM, Doussot, A. (Alexandre), Allen, Peter J., Wiggers, JK, Jarnagin, W.R. (William R.), DeMatteo, Ronald P., Jarnagin, WR, van Gulik, Thomas M., Groot Koerkamp, B; id_orcid, DeMatteo, R.P. (Ronald P.), Busch, Olivier R., Besselink, M.G. (Marc), Busch, O.R.C. (Olivier), Wiggers, Jimme K., Kingham, T.P. (T. Peter), Jarnagin, William R., Klaveren, D. (David) van, Doussot, Alexandre, Cieslak, Kasia P., van Klaveren, David, Allen, PJ, Busch, OR, DeMatteo, RP, Groot Koerkamp, B, Doussot, A, D'Angelica, MI, Kingham, TP, D'Angelica, Michael I., Kingham, T. Peter, Groot Koerkamp, B. (Bas), Allen, P.J. (Peter), Groot Koerkamp, Bas, Besselink, MG, Gouma, DJ, Cieslak, KP, Gouma, Dirk J., Gouma, D.J. (Dirk)   +41 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Liver-limited resectable stage IV: current reality and future perspectives [PDF]

, 2013
With refinements in patient selection criteria and surgical techniques, as well as with implementation of a multimodal approach, liver resection permits to obtain 5-year overall survival rates of 50–58%.
Conci, S., Dario Ribero, Simone Conci, Ribero, D.   +3 more
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

ALPPS for cirrhotic liver [PDF]

Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) has been regarded as one of the most novel procedures for flow modulation in future liver remnant in recent years. The initial results for ALPPS procedure were criticized
Chan, Albert Chi Yan, Au, Kin Pan
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Enhancing liver regeneration prior to resection: A review of embolic materials utilized in portal vein embolization

Asian Journal of Surgery
Portal vein embolization (PVE) plays a pivotal role in the management of liver tumors, as it selectively interrupts the portal vein's branches to stimulate the expansion of the Future Liver Remnant (FLR), consequently mitigating the risks of ...
Boyang Wu, Yuewei Zhang
doaj   +1 more source