Results 121 to 130 of about 53,164 (268)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Challenges and opportunities in financing urban primary healthcare in Iran: pathways to universal health coverage

BMC Primary Care
Background Urban primary health care (UPHC) seeks to address the growing health needs of urban populations and improve public health outcomes. However, its implementation faces significant barriers, particularly in financing mechanisms, which often ...
Leila Zamani-Nezhad, Mahmood Nekoei-Moghadam, Mohammadreza Amiresmaili, Ali Akbar Haghdoost, Vahid Yazdi-Feyzabadi   +4 more
doaj   +1 more source

Navigating the Maze of Futures Studies : A reflexive outlook

Emerging as a futurist and positioning oneself as such is a nuanced and difficult path to navigate. This paper explores our experiences as aspiring foresight professionals through a collaborative autoethnographic approach using our experiences and ...
Önnered, Simon,, Chichilanov, Valeriy,
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Identification of driving forces, uncertainties and future scenarios of Iran\'s environment

سلامت و محیط, 2020
Background and Objective: Global macro trends on the one hand, and domestic trends and effective factors on the other, have put the future of the Iranchr('39')s environment in a state of uncertainty with concern.
A Rezayan Ghayehbashi, E Marzban
doaj  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Multiple Narratives of the Futures of the Global Financial Crisis

, 2010
Using causal layered analysis, the underlying stories of the global financial crisis are explored. The seven narratives presented are the GFC as: (1) a mortgage crisis, (2) a global banking crisis, (3) creative destruction, as part of natural cycles, (4)
Inayatullah, S
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Comprehensive conceptual framework for futures studies in health. [PDF]

Med J Islam Repub Iran, 2019
Mehrolhassani MH, Haghdoost A, Dehnavieh R, Pourhosseini SS.   +3 more
europepmc   +1 more source

Beyond the Pendulum of the General and the Landlord-Politician: Understanding and Creating Alternative Futures for Pakistan

, 2008
In this essay, I outline five futures for Pakistan: (1) the Pendulum continues forever, (2) Collapse, (3) joining Chindia, (4) the Great Game, and (5) a South Asian Confederation.
Inayatullah, S
core