Results 101 to 110 of about 514,617 (308)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Economic burden of cardiovascular diseases among elderly patients in Iran: a case from a developing country

BMC Health Services Research
Background Cardiovascular diseases (CVDs) are the leading cause of mortality and morbidity worldwide, particularly among the aging population. This study aims to evaluate the economic burden of CVDs among Iranians aged 60 years and older.
Mohammad Tasavon Gholamhoseini, Sepideh Arjomand Kermani, Vahid Yazdi-Feyzabadi, Reza Goudarzi   +3 more
doaj   +1 more source

Emergence of Foresight Activities in Swedish Government Authorities [PDF]

This paper discusses and aims to explain the emergence of foresight activities in Swedish government authorities, including environmental scanning and analysis, futures studies and other activities trying to detect and analyse change in the surroundings ...
Lundqvist, Torbjörn
core  

Introduction [PDF]

, 1982
This issue of Explorations in Ethnic Studies brings into focus the vision NAIES has had from the onset, i.e., the pursuit of ”explorations and solutions” to problems within the context of oppression as they relate to the coloured ethnic minority ...
Irby, Charles C.
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Living on the slum areas in the shadow of drought: a qualitative analysis of lived experience of migrant households facing drought in Southeast of Iran

BMC Public Health
Background Drought is one of the most destructive and complex natural hazards, with direct and indirect effects, especially economic effects, on society and households. It affects the well-being and life satisfaction of households.
Minoo Mohammadkhani, Nouzar Nakhaee, Reza Goudarzi, Mahmood Nekoei-Moghadam, Mohsen Aminizadeh   +4 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Realized Volatility and Correlation in Grain Futures Markets: Testing for Spill-Over Effects [PDF]

Fluctuations in commodity prices are a major concern to many market participants. This paper uses realized volatility methods to calculate daily volatility and correlation estimates for three grain futures prices (corn, soybean and wheat).
Hristos Doucouliagos, Jae H. Kim
core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Breaking barriers: challenges faced by the older adults in accessing primary healthcare in a developing country

BMC Geriatrics
Background Given the growing older adults, ensuring their access to primary and basic healthcare services is crucial. Older adults face significant challenges in accessing care, making the develop and implementation of targeted programs vital. This study
Vahid Yazdi-Feyzabadi, Mahin Sabermahani, Vahidreza Borhaninejad, Mahla Iranmanesh   +3 more
doaj   +1 more source