Results 101 to 110 of about 53,164 (268)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Economic burden of cardiovascular diseases among elderly patients in Iran: a case from a developing country

BMC Health Services Research
Background Cardiovascular diseases (CVDs) are the leading cause of mortality and morbidity worldwide, particularly among the aging population. This study aims to evaluate the economic burden of CVDs among Iranians aged 60 years and older.
Mohammad Tasavon Gholamhoseini, Sepideh Arjomand Kermani, Vahid Yazdi-Feyzabadi, Reza Goudarzi   +3 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Living on the slum areas in the shadow of drought: a qualitative analysis of lived experience of migrant households facing drought in Southeast of Iran

BMC Public Health
Background Drought is one of the most destructive and complex natural hazards, with direct and indirect effects, especially economic effects, on society and households. It affects the well-being and life satisfaction of households.
Minoo Mohammadkhani, Nouzar Nakhaee, Reza Goudarzi, Mahmood Nekoei-Moghadam, Mohsen Aminizadeh   +4 more
doaj   +1 more source

Futures of the climate action movement: Insights from an integral futures approach [PDF]

, 2011
In this paper, I use a Wilberian integral futures approach to examine visions of the future within the climate action movement and identify sources of agreement and contention.
Riedy, C
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Alternative Futures of Occupational Therapy and Therapists

, 2007
Alternatives Futures of Occupational Therapy are explored. These scenarios include: (1) business as usual where the future is known – traditional bureaucracies and traditional caseloads; (2) social justice based focused on rights; (3) transformative ...
Inayatullah, S
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Purposes and Assumptions of Islamic Futures Studies [PDF]

بهبود مدیریت, 2014
Futures Studies is a knowledge based on practice and cannot be merely shaped by theoretic thoughts. Therefore we can not describe futures studies well until it has got practical.
Mohammad Rahim Eivazi, Abdurrahim Pedram
doaj  

Back to futures: futures studies and its role in addressing the great civilisational challenges [PDF]

, 2020
Concern for human futures can arguably be said to be at its most urgent in the history of humanity. Viable alternative human futures seem to be on the decline as emergencies that threaten humanity increase.
van der Laan, Luke
core