Results 91 to 100 of about 53,164 (268)

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

The minimum data set for goiter disorder in Iran

Digital Health
Background and objective Goiter, primarily caused by iodine deficiency, remains one of the most common endocrine disorders globally. The absence of standardized and structured data hampers effective monitoring, diagnosis, and management. This study aimed
Mohammad Mehdi Ghaemi, Sanaz Numdari, Sadrieh Hajesmaeel-Gohari, Parastoo Amiri, Farzaneh Behnam   +4 more
doaj   +1 more source

Creativity and Futures Studies

Creativity Studies and Futures Studies are both forward-looking disciplines, projecting onto possible futures the effects of human thinking, decision making, and actions.
Corazza, Giovanni Emanuele
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Corrigendum to “Experiences of the development and use of scenarios for evaluating Swedish national environmental objectives” [Futures 43 (2011) 1–15]

, 2011
This paper presents and evaluates a method for encouraging long-term thinking and for considering a variety of scenarios in environmental policy processes.
Svenfelt, Åsa,, Mattias Höjer, Karl Henrik Dreborg, Dreborg, Karl Henrik,, Åsa Svenfelt, Höjer, Mattias,, Gunnarsson-Östling, Ulrika,, Rebecka Engström, Ulrika Gunnarsson-Östling, Engström, Rebecka,   +9 more
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Musculoskeletal disorders among taxi drivers: a systematic review and meta-analysis

BMC Musculoskeletal Disorders
Introduction Taxi drivers, as professional drivers, encounter numerous ergonomic risk factors related to musculoskeletal disorders (MSDs) because of the demands of their jobs. This study conducted as a systematic review and meta-analysis aimed to explore
Ehsan Rezaei, Fatemeh Shahmahmoudi, Faezeh Makki, Fatemeh Salehinejad, Hassan Marzban, Zahra Zangiabadi   +5 more
doaj   +1 more source