Results 71 to 80 of about 53,164 (268)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
The accuracy of gist: Rethinking public awareness of attitude change
Judgment and Decision MakingDoes the public accurately perceive how views change in society? Prevailing narratives suggest not, but we argue this conclusion stems from searching for the wrong kind of accuracy—demanding pollster-like precision instead of acknowledging the public’s ...
Irina Vartanova +2 more
doaj +1 more source
, 2017 This essay is part of a special “Symposium” issue of the Journal of Futures Studies focusing on Intuition in Futures Work. It builds on the brief summary review of conceptual positions about practical intuition contained in my brief introduction to the ...
Markley, Oliver
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Futures studies as social science : An analytic scheme and a case study
, 2008 Several authors in the futures studies field have in their efforts to improve quality argued that better methods must be developed, which makes sense. But the theoretical awareness in the substantive questions upon which the studies are based is probably
Ehliasson, Kent,
core +1 more source
Convex geometries yielded by transit functions [PDF]
Opuscula MathematicaLet \(V\) be a finite nonempty set. A transit function is a map \(R:V\times V\rightarrow 2^V\) such that \(R(u,u)=\{u\}\), \(R(u,v)=R(v,u)\) and \(u\in R(u,v)\) holds for every \(u,v\in V\).
Manoj Changat +3 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
, 2008 The visions we hold of the future, whether they are of utopias or dystopias, are not simply a matter of personal imagination. Our conceptions of the future are mediated to us as much as they are privately created by us.
Edwards, Mark G.,
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Elevating Creativity and Criticality Through Game-Based Futuring: An action research case study in futures studies [PDF]
, 2017 To address humanity’s greatest challenges, futures studies practices are needed which can break through the trappings of present-day understandings. Combining criticality, challenging assumptions and questioning the present and future, and creativity ...
Balcom Raleigh, Nicolas
core