Results 111 to 120 of about 514,617 (308)
Purposes and Assumptions of Islamic Futures Studies [PDF]
بهبود مدیریت, 2014 Futures Studies is a knowledge based on practice and cannot be merely shaped by theoretic thoughts. Therefore we can not describe futures studies well until it has got practical.
Mohammad Rahim Eivazi, Abdurrahim Pedram
doaj
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Establishing a safe community program: a qualitative systematic literature review
BMC Public HealthResearch objective Accidents are a leading cause of preventable deaths in many countries around the world. Non-fatal but disabling health consequences account for a significant portion of the injury and harm resulting from accidents.
Nourolhoda Fakhrzad +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Principle Concepts in Futures Studies: A Narrative Review
Health Technology Assessment in ActionContext: Our world is characterized by a dynamic landscape of variations, complexities, uncertainties, and ambiguities (VUCA). These elements manifest in various domains, including politics, economics, communication, information, science, and research ...
Zahra Heydari Fard +2 more
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Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
BMC PsychologyIntroduction Given the strict prohibition of alcohol use in certain religions, such as Islam, and the criminalization of its production, distribution, and consumption in a country like Iran, it becomes essential to utilize a standardized and culturally ...
Mahsa Janati +6 more
doaj +1 more source
Alternative futures of rural areas in the EU; A comparative analysis of scenaria studies [PDF]
What does rural Europe look like in 2030? Is agriculture still the main land user? In recent years, studies such as ESPON, Eururalis, SCENAR2020, SENSOR, SEAMLESS and PRELUDE have tried to address these questions.
Jansson, K.M., Terluin, I.J.
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source