Results 91 to 100 of about 2,416 (201)

Real-time toxicity prediction of Aconitum stewing system using extractive electrospray ionization mass spectrometry

Acta Pharmaceutica Sinica B, 2020
Due to numerous obstacles such as complex matrices, real-time monitoring of complex reaction systems (e.g., medicinal herb stewing system) has always been a challenge though great values for safe and rational use of drugs.
Zi-Dong Qiu, Jin-Long Chen, Wen Zeng, Ying Ma, Tong Chen, Jin-Fu Tang, Chang-Jiang-Sheng Lai, Lu-Qi Huang   +7 more
doaj   +1 more source

Pan‐cancer analysis and oncogenic implications of MGAM and MGAM2: Toward precision oncology and drug repurposing in colorectal cancer

Journal of Cell Communication and Signaling, Volume 19, Issue 3, September 2025.
Abstract Cancer remains a major global health challenge, with high prevalence and mortality rates emphasizing the urgent need for innovative treatment strategies. Although precision oncology offers tailored therapies based on genetic profiles, the clinical translation of genomic insights has been slow.
Rawaa Chasib Mezher, Hanieh Azari, Reza Khayami, Hamid Fiuji, Farzaneh Alizadeh, Ladan Goshayeshi, Majid Rajabian, Ibrahim Saeed Gataa, Seyed Mahdi Hassanian, Amir Avan   +9 more
wiley   +1 more source

Heat map of the abundance of rhizosphere fungi around Fuzi roots at the genus level.

, 2018
Heat map of the abundance of rhizosphere fungi around Fuzi roots at the genus level.
Huan Wen (508323), Jihai Gao (5916890), Wei Wang (17594), Dayan Zhang (614661), Cheng Peng (118834), Qihao Wang (4483174)   +5 more
core   +1 more source

Alkaloids of Aconiti Lateralis Radix Praeparata inhibit growth of non-small cell lung cancer by regulating PI3K/Akt-mTOR signaling and glycolysis

Communications Biology
Aconiti Lateralis Radix Praeparata (Fuzi in Chinese) is widely used in the clinical treatment of tumors. This study aims to explore the active fractions and underlying mechanisms of Fuzi in the treatment of non-small cell lung cancer (NSCLC).
Wen Zhang, Shuhui Cai, Lihong Qin, Yaru Feng, Menglei Ding, Zichen Luo, Jinjun Shan, Liuqing Di   +7 more
doaj   +1 more source

Research progress on traditional Chinese medicine animal models of post‐stroke depression and pathological insights

Animal Models and Experimental Medicine, Volume 8, Issue 8, Page 1387-1399, August 2025.
Post‐stroke depression (PSD) animal model of traditional Chinese medicine (TCM) combined with disease and syndrome often uses western medicine surgery (including: middle cerebral artery embolization to construct cerebral ischemia, or brain injection of collagenase to construct cerebral hemorrhage) combined with other methods (including: isolation ...
Jielin Wang, Wenlu Ma, Wei Wu, Yujuan Fu, Hui Li   +4 more
wiley   +1 more source

Study the past if you would define the future: Historical methods in medical education scholarship

Medical Education, Volume 59, Issue 8, Page 823-832, August 2025.
Abstract Introduction A study was conducted to describe the state of historical scholarship in medical education including its strengths and opportunities as well as its shortcomings, lacunae, inattentions, and failings. The study took a particular focus on historical methods and methodologies and whether they have been applied appropriately and with ...
Rachel Ellaway, Anna MacLeod, Susan van Schalkwyk, Jennifer Cleland   +3 more
wiley   +1 more source

Relative abundance of rhizosphere fungi around Fuzi roots at the genus level.

, 2018
Relative abundance of rhizosphere fungi around Fuzi roots at the genus level.
Huan Wen (508323), Jihai Gao (5916890), Wei Wang (17594), Dayan Zhang (614661), Cheng Peng (118834), Qihao Wang (4483174)   +5 more
core   +1 more source

Mechanism Analysis of Zuogui and Yougui Pills on Diabetic Nephropathy Through Transcriptional Regulatory Networks of HIF1A and PPARA

Food Science &Nutrition, Volume 13, Issue 6, June 2025.
The shared mechanisms of Zuogui Pill (ZGP) and Yougui Pill (YGP) for treating diabetic nephropathy is HIF1A‐CA9‐PDK1 and PPARA‐PDK4. ZGP and YGP inhibited renal fibrosis and relieved the decrease in glucose consumption through transcriptional regulatory network of HIF1A and PPARA.
Liansheng Qiao, Xiaopeng Zhao, Anlei Yuan, Chaoqun Liu, Zewen Wang, Xiaoqian Huo, Shijie Bi, Jiaye Tian, Bin Yu, Zhaozhou Lin, Yanling Zhang, Jiwang Zhang   +11 more
wiley   +1 more source

Machine Learning‐Enabled Drug‐Induced Toxicity Prediction

Advanced Science, Volume 12, Issue 16, April 24, 2025.
Unexpected toxicity accounts for 30% of drug development failures. This review highlights ML innovations in predicting drug‐induced toxicity, emphasizing comparative analyses, interpretable algorithms, and multi‐source data integration. It categorizes toxicity types, summarizes ML models, and organizes key databases, offering strategies to address ...
Changsen Bai, Lianlian Wu, Ruijiang Li, Yang Cao, Song He, Xiaochen Bo   +5 more
wiley   +1 more source

DataSheet1_Effect of Mahuang Fuzi and Shenzhuo Decoction on Idiopathic Membranous Nephropathy: A Multicenter, Nonrandomized, Single-Arm Clinical Trial.zip

, 2021
Objective: To explore the clinical effect of Mahuang Fuzi and Shenzhuo Decoction on idiopathic membranous nephropathy.Methods: This study is a multicenter, nonrandomized, single-arm clinical trial carried out as per the objective performance criteria ...
Zhaocheng Dong (11574475), Xuefei Tian (4630945), Yu Gao (69071), Hongliang Rui (11574490), Haoran Dai (11574478), Xiaoyan Zhang (50085), Hanxue Jiang (11574481), Zhendong Feng (11574484), Guiming Li (5228525), Meiqi Liu (3129000), Aijie Ren (11574487), Baoli Liu (3751885), Wenbin Liu (174604), Xiaolan Li (380432), Fei Liu (21082)   +14 more
core   +1 more source