Research progress of aconitine toxicity and forensic analysis of aconitine poisoning [PDF]
Forensic Sciences Research, 2020 Chinese herbal medicines have been extensively used in China and other countries for centuries. Aconitine, a diterpenoid alkaloid extracted from Aconitum plants, has anti-inflammatory and analgesic activities, but can also induce severe arrhythmia and ...
Jun Hu, Xincai Zhang, Yuanyi Zuo
exaly +4 more sources
Magnesium Sulfate Combination Therapy for Aconitine‐Induced Electrical Storm [PDF]
Annals of Noninvasive ElectrocardiologyWe present the case of a 74‐year‐old man who developed 28 episodes of electrical storm secondary to aconitine poisoning from homemade herbal wine consumption, followed by complete recovery through 28 electrical cardioversions, hemopurification, and ...
Liujiang Ran, Jun Si, Yanyan Liu
doaj +3 more sources
Neurotoxicity mechanism of aconitine in HT22 cells studied by microfluidic chip-mass spectrometry
Journal of Pharmaceutical Analysis, 2023 Aconitine, a common and main toxic component of Aconitum, is toxic to the central nervous system. However, the mechanism of aconitine neurotoxicity is not yet clear.
yingrui zhang
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In Vitro and in Vivo Anticancer Activity of Aconitine on Melanoma Cell Line B16
Molecules, 2013 The anti-tumor effect of aconitine in melanoma cell line B16 has been studied in this paper. We found that B16 cells showed significantly reduced growth rates and increased apoptotic effects in the presence of aconitine.
Juan Du
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Aconitine promotes ROS-activated P38/MAPK/Nrf2 pathway to inhibit autophagy and promote myocardial injury [PDF]
Journal of Cardiothoracic SurgeryBackground Aconitine has cardiotoxicity, but the mechanism of cardiotoxicity induced by aconitine is limited. The aim of this study was to investigate the mechanism of myocardial injury induced by aconitine.
Chunai Yang +6 more
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Inhibitory Effect of Aconitine on Colorectal Cancer Malignancy via Inducing Apoptosis and Suppression of Cell Motion [PDF]
The Turkish Journal of GastroenterologyBackground/Aims: The incidence of colorectal cancer (CRC) has been increasing in recent years worldwide. Aconitine is a diester diterpenoid alkaloid that exhibits an antitumor role in several cancers.
Xuehui Li +4 more
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Combined blood purification and antiarrhythmic therapy for acute aconitine poisoning with refractory arrhythmias: a case-based mechanistic evaluation and treatment strategy optimization [PDF]
European Journal of Medical ResearchIntroduction Aconitine poisoning from traditional Chinese medicine is life-threatening, associated with arrhythmias and shock. Early diagnosis and multidisciplinary treatment are essential due to the lack of specific antidotes.
Cheng Yang +4 more
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Learnings from Separate Aconitum Poisonings in British Columbia and Ontario, Canada in 2022 [PDF]
ToxinsBackground: Three aconitine poisoning events occurred in two Canadian provinces in 2022: one in British Columbia (BC) and two in Ontario (ON). Aconitine is a potent alkaloid found in several species of the plant Aconitum, containing cardiotoxins and ...
Lorraine McIntyre +17 more
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ZIF-8 Selective Dispersive Solid-Phase Extraction-LC-MS/MS Method for the Determination of Aconitine alkaloids in Rat Plasma: Application in Pharmacokinetic Studies [PDF]
Journal of Analytical Methods in ChemistryConclusion: This study introduces a novel d-SPE–LC–MS/MS method based on ZIF-8 for the analysis of aconitine alkaloids in plasma, facilitating pharmacokinetic studies of Fuzi.
Yang Yang +8 more
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When the cure turns toxic: a case report on toxic alkaloids identified by public mass spectral databases [PDF]
Frontiers in MedicineAconitine is a highly toxic diterpenoid alkaloid, produced by root of Aconitum brachypodum Diels. (A. brachypodum), also known as “Xue-Shang-Yi-Zhi-Hao,” that is still used in Chinese herbal medicines.
Yuyan Lei +7 more
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