Results 1 to 10 of about 264 (129)
Research progress of aconitine toxicity and forensic analysis of aconitine poisoning [PDF]
Forensic Sciences Research, 2020 Chinese herbal medicines have been extensively used in China and other countries for centuries. Aconitine, a diterpenoid alkaloid extracted from Aconitum plants, has anti-inflammatory and analgesic activities, but can also induce severe arrhythmia and ...
Yuanyi Zuo, Xincai Zhang, Shaohua Zhu
exaly +4 more sources
Neurotoxicity mechanism of aconitine in HT22 cells studied by microfluidic chip-mass spectrometry
Journal of Pharmaceutical Analysis, 2023 Aconitine, a common and main toxic component of Aconitum, is toxic to the central nervous system. However, the mechanism of aconitine neurotoxicity is not yet clear.
Jin-Ming Lin +2 more
exaly +3 more sources
Frontiers in Pharmacology, 2023 Background: Herbs originating from the Aconitum L. (Ranunculaceae), such as Aconitum carmichaelii Debeaux. (Wutou), Aconitum pendulum Busch. (Tiebangchui), and Aconitum kusnezoffii Reichb. (Caowu), etc.
Shaohui Wang, Nan Xing, Xing Nan
exaly +3 more sources
Biological and Pharmaceutical Bulletin, 2003 A reliable enzyme immunoassay (EIA) method was developed for quantitative determination of aconitine with high sensitivity and specificity. The bovine serum albumin (BSA)- and beta-galactosidase (beta-Gal) conjugates as immunogens and enzyme-labeled antigens were prepared by coupling of their proteins with succinic acid (short chain length; n=2, where ...
Teruaki Akao
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Frontiers in Pharmacology, 2022 Aconitine is one of the main bioactive and toxic ingredients of Aconitum species. Increasingly, aconitine has been reported to induce neurotoxicity. However, whether aconitine has effects on the dopaminergic nervous system remains unclear. In this study,
Jie Zhou +13 more
doaj +1 more source
Pakistan Journal of Pharmaceutical Sciences, 2021 Aconitine, the main component in Radix Aconiti Lateralis Preparata, not only exerts the anti-tumor effect on Hepatocellular Carcinoma (HCC) but also damages on immune system. In the present study, Crude Monkshood Polysaccharide (CMP), another one natural
Fei Yao +6 more
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Pharmacological Research - Modern Chinese Medicine, 2022 Ethnopharmacological relevance: Aconitum kusnezoffii Reichb. is one of the plants of Aconitum genus, and it′s root, flower, bud, and leaf has been used for traditional Mongolian medicine to bactericidal, relieve pain, collapse, rheumatic fever and so on,
Selinge Bai +5 more
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Frontiers in Pharmacology, 2021 Aconitine is attracting increasing attention for its unique positive inotropic effect on the cardiovascular system, but underlying molecular mechanisms are still not fully understood.
Li-Zhen Qiu +8 more
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Quantitative Assessment of the Influence of Rhizoma Zingiberis on the Level of Aconitine in Rat Gut Sacs and Qualitative Analysis of the Major Influencing Components of Rhizoma Zingiberis on Aconitine Using UPLC/MS. [PDF]
PLoS ONE, 2015 This study attempted to clarify the material basis for the detoxification of Rhizoma Zingiberis (RZ) on aconitine, an analgesic drug, by quantitatively assessing the influence of RZ on the in vitro intestinal concentration of aconitine using an everted ...
Yang Xin, Shuying Liu
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Sweroside Alleviated Aconitine-Induced Cardiac Toxicity in H9c2 Cardiomyoblast Cell Line
Frontiers in Pharmacology, 2018 Aconitine is the main bioactive ingredient of Aconitum plants, which are well-known botanical herbs in China. Aconitine is also notorious for its high cardiotoxicity, as it can induce life-threatening ventricular arrhythmias. Unfortunately, there are few
Li-Qun Ma +8 more
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