Results 11 to 20 of about 4,322 (208)

Aconitine in Synergistic, Additive and Antagonistic Approaches [PDF]

Toxins
Aconitine is a highly poisonous C19-diterpenoid alkaloid identified and isolated from the species of the genus Aconitum. Aconitine is indicated in the treatment of cardiovascular diseases (CVDs) and, due to its neurotoxic effects, is a very effective ...
Nicoleta Anca Şuţan, Alina Paunescu, Carmen Topala, Codruţa Dobrescu, Maria Cristina Ponepal, Diana Ionela Popescu (Stegarus), Liliana Cristina Soare, Radu Tamaian   +7 more
doaj   +2 more sources

Uncovering the poisonous aconitine containing plants in homemade herbal liquor using a convergent approach [PDF]

Scientific Reports
Human exposure to toxic plants is a global concern, with numerous reported cases of accidental poisoning. In this study, a patient experienced poisoning after inadvertently consuming an herbal preparation preserved in alcohol.
Aekkhaluck Intharuksa, Narawudt Prasertwitayakij, Suthira Yanaso, Ampai Phrutivorapongkul, Wannaree Charoensup, Kanika Thongkhao, Yohei Sasaki, Wanwarang Wongcharoen   +7 more
doaj   +2 more sources

Magnesium in Aconitine-Induced Electrical Storm-Mechanism Yes, Mandate No. [PDF]

Ann Noninvasive Electrocardiol
Critical analysis reveals verapamil is contraindicated in aconitine poisoning and flecainide is superior to magnesium monotherapy. Our algorithm positions Class IC antiarrhythmics as first‐line, with magnesium serving as adjunctive metabolic therapy. ABSTRACT Aconitine poisoning produces lethal ventricular arrhythmias through persistent activation of ...
Zhan ZQ, Xu HJ.
europepmc   +2 more sources

Dopamine Homeostasis Imbalance and Dopamine Receptors-Mediated AC/cAMP/PKA Pathway Activation are Involved in Aconitine-Induced Neurological Impairment in Zebrafish and SH-SY5Y Cells

Frontiers in Pharmacology, 2022
Aconitine is one of the main bioactive and toxic ingredients of Aconitum species. Increasingly, aconitine has been reported to induce neurotoxicity. However, whether aconitine has effects on the dopaminergic nervous system remains unclear. In this study,
Jie Zhou, Jie Zhou, Cheng Peng, Qiuju Li, Xiaoyu Yan, Liang Yang, Mengting Li, Xiaoyu Cao, Xiaofang Xie, Dayi Chen, Chaolong Rao, Sizhou Huang, Fu Peng, Xiaoqi Pan   +13 more
doaj   +1 more source

De nove transcriptome sequencing identifies genes involved in aconitine-type alkaloids biosynthesis in Aconitum kusnezoffii Reichb.

Pharmacological Research - Modern Chinese Medicine, 2022
Ethnopharmacological relevance: Aconitum kusnezoffii Reichb. is one of the plants of Aconitum genus, and it′s root, flower, bud, and leaf has been used for traditional Mongolian medicine to bactericidal, relieve pain, collapse, rheumatic fever and so on,
Selinge Bai, Saqieer Sartagnuud, Tu-ya Wang, Gui-hua Bao, Shu-yin Bao, Wuliji Ao   +5 more
doaj   +1 more source

Divergent Total Synthesis of Denudatine Alkaloids Cochlearenine, Macrocentrine, Dictizine, 15-Veratroyl-17-Acetyl-19-Oxodictizine, and the Proposed Structure of Acochlearine. [PDF]

Angew Chem Int Ed Engl
An intramolecular Mannich reaction (A/B/E/F rings) and intermolecular Diels–Alder reactions (C/D rings) afforded a cage‐like hexacyclic core skeleton of denudatine alkaloids. Derivatization of the hexacyclic intermediate enabled the first asymmetric total syntheses of four denudatine alkaloids: (–)‐cochlearenine, (–)‐macrocentrine, (–)‐dictizine, and (–
Kawano S, Miyamoto N, Fujioka K, Toya H, Sakata J, Tokuyama H.   +5 more
europepmc   +3 more sources

Repeated Aconitine Treatment Induced the Remodeling of Mitochondrial Function via AMPK–OPA1–ATP5A1 Pathway

Frontiers in Pharmacology, 2021
Aconitine is attracting increasing attention for its unique positive inotropic effect on the cardiovascular system, but underlying molecular mechanisms are still not fully understood.
Li-Zhen Qiu, Li-Zhen Qiu, Wei Zhou, Lan-Xin Yue, Yi-Hao Wang, Fei-Ran Hao, Peng-Yan Li, Yue Gao, Yue Gao   +8 more
doaj   +1 more source

Antitumor effects and potential mechanisms of aconitine based on preclinical studies: an updated systematic review and meta-analysis

Frontiers in Pharmacology, 2023
Background: Herbs originating from the Aconitum L. (Ranunculaceae), such as Aconitum carmichaelii Debeaux. (Wutou), Aconitum pendulum Busch. (Tiebangchui), and Aconitum kusnezoffii Reichb. (Caowu), etc.
Gelin Xiang, Gelin Xiang, Nan Xing, Nan Xing, Shaohui Wang, Shaohui Wang, Yi Zhang, Yi Zhang   +7 more
doaj   +1 more source

Quantitative Assessment of the Influence of Rhizoma Zingiberis on the Level of Aconitine in Rat Gut Sacs and Qualitative Analysis of the Major Influencing Components of Rhizoma Zingiberis on Aconitine Using UPLC/MS. [PDF]

PLoS ONE, 2015
This study attempted to clarify the material basis for the detoxification of Rhizoma Zingiberis (RZ) on aconitine, an analgesic drug, by quantitatively assessing the influence of RZ on the in vitro intestinal concentration of aconitine using an everted ...
Yang Xin, Shuying Liu
doaj   +1 more source

An Updated Meta-Analysis Based on the Preclinical Evidence of Mechanism of Aconitine-Induced Cardiotoxicity

Frontiers in Pharmacology, 2022
Background: Most Aconitum species in traditional Chinese medicine have the effect of dispelling wind, dehumidifying, warming the meridian, and relieving pain.
Hong Jiang, Yating Zhang, Yating Zhang, Yi Zhang, Xiaobo Wang, Xiaobo Wang, Xianli Meng, Xianli Meng, Xianli Meng   +8 more
doaj   +1 more source