Results 11 to 20 of about 2,497 (169)

Uncovering the poisonous aconitine containing plants in homemade herbal liquor using a convergent approach [PDF]

Scientific Reports
Human exposure to toxic plants is a global concern, with numerous reported cases of accidental poisoning. In this study, a patient experienced poisoning after inadvertently consuming an herbal preparation preserved in alcohol.
Aekkhaluck Intharuksa, Narawudt Prasertwitayakij, Suthira Yanaso, Ampai Phrutivorapongkul, Wannaree Charoensup, Kanika Thongkhao, Yohei Sasaki, Wanwarang Wongcharoen   +7 more
doaj   +2 more sources

Aconitine in Synergistic, Additive and Antagonistic Approaches [PDF]

Toxins
Aconitine is a highly poisonous C19-diterpenoid alkaloid identified and isolated from the species of the genus Aconitum. Aconitine is indicated in the treatment of cardiovascular diseases (CVDs) and, due to its neurotoxic effects, is a very effective ...
Nicoleta Anca Şuţan, Alina Paunescu, Carmen Topala, Codruţa Dobrescu, Maria Cristina Ponepal, Diana Ionela Popescu (Stegarus), Liliana Cristina Soare, Radu Tamaian   +7 more
doaj   +2 more sources

When the cure turns toxic: a case report on toxic alkaloids identified by public mass spectral databases [PDF]

Frontiers in Medicine
Aconitine is a highly toxic diterpenoid alkaloid, produced by root of Aconitum brachypodum Diels. (A. brachypodum), also known as “Xue-Shang-Yi-Zhi-Hao,” that is still used in Chinese herbal medicines.
Yuyan Lei, Yuyan Lei, Qin Yi, Junli Lu, Yanghao Sheng, Yanghao Sheng, Ying Xue, Ying Xue   +7 more
doaj   +2 more sources

Herbal Combination of <i>Angelica gigas</i>, <i>Zingiber officinale</i>, and <i>Aconitum carmichaeli</i> Alleviates High Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice Through NRF2-Mediated Regulation of Adipogenesis and Non-Shivering Thermogenesis. [PDF]

Food Sci Nutr
The multi‐herbal formula JI017, consisting of Angelica gigas, Zingiber officinale , and Aconitum carmichaeli, alleviates high‐fat diet‐induced non‐alcoholic fatty liver disease by activating the NRF2 antioxidant pathway. This central mechanism suppresses adipogenesis in the liver and white adipose tissues while simultaneously enhancing thermogenesis in
Kim H, Kim HL, Boo M, Choi H, Han J, Nam S, Kang SJ, Kim JK, Han Y, Jung JH, Kim W, Kim KI, Um JY, Park J, Otterbein LE, Kim HI, Ko SG.   +16 more
europepmc   +2 more sources

Dopamine Homeostasis Imbalance and Dopamine Receptors-Mediated AC/cAMP/PKA Pathway Activation are Involved in Aconitine-Induced Neurological Impairment in Zebrafish and SH-SY5Y Cells

Frontiers in Pharmacology, 2022
Aconitine is one of the main bioactive and toxic ingredients of Aconitum species. Increasingly, aconitine has been reported to induce neurotoxicity. However, whether aconitine has effects on the dopaminergic nervous system remains unclear. In this study,
Jie Zhou, Jie Zhou, Cheng Peng, Qiuju Li, Xiaoyu Yan, Liang Yang, Mengting Li, Xiaoyu Cao, Xiaofang Xie, Dayi Chen, Chaolong Rao, Sizhou Huang, Fu Peng, Xiaoqi Pan   +13 more
doaj   +1 more source

De nove transcriptome sequencing identifies genes involved in aconitine-type alkaloids biosynthesis in Aconitum kusnezoffii Reichb.

Pharmacological Research - Modern Chinese Medicine, 2022
Ethnopharmacological relevance: Aconitum kusnezoffii Reichb. is one of the plants of Aconitum genus, and it′s root, flower, bud, and leaf has been used for traditional Mongolian medicine to bactericidal, relieve pain, collapse, rheumatic fever and so on,
Selinge Bai, Saqieer Sartagnuud, Tu-ya Wang, Gui-hua Bao, Shu-yin Bao, Wuliji Ao   +5 more
doaj   +1 more source

Antitumor effects and potential mechanisms of aconitine based on preclinical studies: an updated systematic review and meta-analysis

Frontiers in Pharmacology, 2023
Background: Herbs originating from the Aconitum L. (Ranunculaceae), such as Aconitum carmichaelii Debeaux. (Wutou), Aconitum pendulum Busch. (Tiebangchui), and Aconitum kusnezoffii Reichb. (Caowu), etc.
Gelin Xiang, Gelin Xiang, Nan Xing, Nan Xing, Shaohui Wang, Shaohui Wang, Yi Zhang, Yi Zhang   +7 more
doaj   +1 more source

Repeated Aconitine Treatment Induced the Remodeling of Mitochondrial Function via AMPK–OPA1–ATP5A1 Pathway

Frontiers in Pharmacology, 2021
Aconitine is attracting increasing attention for its unique positive inotropic effect on the cardiovascular system, but underlying molecular mechanisms are still not fully understood.
Li-Zhen Qiu, Li-Zhen Qiu, Wei Zhou, Lan-Xin Yue, Yi-Hao Wang, Fei-Ran Hao, Peng-Yan Li, Yue Gao, Yue Gao   +8 more
doaj   +1 more source

Quantitative Assessment of the Influence of Rhizoma Zingiberis on the Level of Aconitine in Rat Gut Sacs and Qualitative Analysis of the Major Influencing Components of Rhizoma Zingiberis on Aconitine Using UPLC/MS. [PDF]

PLoS ONE, 2015
This study attempted to clarify the material basis for the detoxification of Rhizoma Zingiberis (RZ) on aconitine, an analgesic drug, by quantitatively assessing the influence of RZ on the in vitro intestinal concentration of aconitine using an everted ...
Yang Xin, Shuying Liu
doaj   +1 more source

An Updated Meta-Analysis Based on the Preclinical Evidence of Mechanism of Aconitine-Induced Cardiotoxicity

Frontiers in Pharmacology, 2022
Background: Most Aconitum species in traditional Chinese medicine have the effect of dispelling wind, dehumidifying, warming the meridian, and relieving pain.
Hong Jiang, Yating Zhang, Yating Zhang, Yi Zhang, Xiaobo Wang, Xiaobo Wang, Xianli Meng, Xianli Meng, Xianli Meng   +8 more
doaj   +1 more source