Results 41 to 50 of about 2,497 (169)

Construction of a Stable Expression Cell Line of Human Phospholamban

Fayixue Zazhi, 2021
ObjectiveTo construct a cell line that can stably express human phospholamban（PLN） and initially explore its application in the study of myocardial toxicity mechanism.MethodsFastCloning method was used to insert the open reading frame sequence of target ...
CHEN Lan-qing, WANG Yu-ning, LI Dian-yi, XU Lu-yao, LI Lian-jie, LI Ze-hao, LIU Hua, LIU Qian   +7 more
doaj   +1 more source

Hematological and Histopathological Effects of Subacute Aconitine Poisoning in Mouse

Frontiers in Veterinary Science, 2022
Aconitine is the principal toxic ingredient of Aconitum, which can cause systemic poisoning involving multiple organs and systems after animal ingestion.
Hao Lu, Li Mei, Ziyu Guo, Kexin Wu, Yunhao Zhang, Shiyu Tang, Yiru Zhu, Baoyu Zhao   +7 more
doaj   +1 more source

Analytical Aspects of Diterpene Alkaloid Poisoning with Monkshood

Natural Product Communications, 2009
A sensitive and specific method for aconitine extraction from biological samples was developed. Aconitine, the main toxic alkaloid from plants belonging to Aconitum species (family Ranunculaceae), was determined in plant material by an external standard ...
Maria Laura Colombo, Carlo Bugatti, Franca Davanzo, Andrea Persico, Cinzia Ballabio, Patrizia Restani   +5 more
doaj   +1 more source

JI‐CJ002 and Dabrafenib Combination Enhances Antitumor Activity in Melanoma Associated With the Downregulation of B7‐H3

Cancer Science, Volume 117, Issue 6, Page 1651-1666, June 2026.
Schematic pathway diagram illustrating the effects of JI‐CJ002 and dabrafenib on melanoma progression. The combination of JI‐CJ002 and dabrafenib is associated with reduced B7‐H3 expression and modulation of signaling pathways implicated in melanoma progression, including JAK2/STAT3, PI3K/AKT/mTOR, and Rb/E2F1.
Sang‐Eun Lee, Young Ha Kim, Bo Shin Heo, Chunhoo Cheon, Seong‐Gyu Ko   +4 more
wiley   +1 more source

Bioinspired Cold‐Laminated Ultrathin Hydrogels as a Broadly Adaptive Platform for Physiological Monitoring

Advanced Science, Volume 13, Issue 22, 17 April 2026.
A cold‐lamination strategy is introduced to fabricate ultrathin, nanomesh‐reinforced hydrogel bioelectronics with controlled thickness, tunable mechanics, and reversible adhesion. By mechanically interlocking a TPU nanomesh within a temperature‐responsive hydrogel, the platform enables robust epidermal and implantable cardiac interfaces, supporting ...
Hui Chen, Jian Zhou, Jianfei Xie, Lin Shi, Lu Wang, Yuanfan Yang, Yihao Guo, Jianhui Cao, Qingyun Fu, Yongqing Fu, Huigao Duan   +10 more
wiley   +1 more source

Acute poisoning of aconitum: A case report and resuscitative emergency management with amiodarone

Medical Journal of Dr. D.Y. Patil Vidyapeeth, 2022
Aconitine, a plant alkaloid is a usual constituent of various over-the-counter herbal remedies and is an uncommon cause of deliberate poisoning. Herein, we describe an unusual case of poisoning in a young male due to accidental ingestion of aconitine ...
Gautam Jesrani, Amanjot Kaur, Monica Gupta, Harsheel Gupta   +3 more
doaj   +1 more source

Progress on the Protective Effect and the Mechanism of Chinese Medicine Injection and Chinese Medicine Monomeric Small Molecules on Sepsis‐Related Liver Injury

Gut Medicine, Volume 2, Issue 1, Page 40-57, March 2026.
ABSTRACT Sepsis‐related liver injury (SRLI) involves multiple interrelated pathological processes, including excessive inflammation, oxidative imbalance, mitochondrial dysfunction, dysregulated autophagy, and microcirculatory impairment. Increasing evidence indicates that traditional Chinese medicine (TCM)–based interventions, particularly Chinese ...
Xiang Yunsheng, Yan Yumeng
wiley   +1 more source

Effect of processing on the alkaloids in Aconitum tubers by HPLC-TOF/MS

Journal of Pharmaceutical Analysis, 2017
According to the Chinese Pharmacopoeia 2015, only processed Aconitum tubers can be clinically applied, and the effect of processing is unclear. This research aimed to explore the effect of processing on cardiac efficacy of alkaloids in Aconitum tubers ...
Min Liu, Yan Cao, Diya Lv, Wen Zhang, Zhenyu Zhu, Hai Zhang, Yifeng Chai   +6 more
doaj   +1 more source

Antiarrhythmic properties of N-Deacetyllappaconitine Hydrochloride

Фармакокинетика и Фармакодинамика, 2022
The aim of the investigation was the research of the N-deacetyllappaconitine hydrochloride antiarrhythmic properties. It was found that the studied substance was effective on the cardiac arrhythmias model caused by aconitine hydrochloride, but does not ...
S. A. Kryzhanovskii, M. S. Yunusov, I. B. Tsorin, V. V. Barchukov, E. I. Barchukova   +4 more
doaj   +1 more source

Traditional Chinese Medicine as an Integrative Adjunct in Oncology Perioperative Practice: Analgesia, Immune Modulation, and Translational Challenges

Medicine Bulletin, Volume 2, Issue 2, Page 184-204, March 2026.
ABSTRACT Traditional Chinese medicine (TCM), including herbal analgesic adjuvants and acupuncture‐based interventions, has gained increasing attention as an integrative strategy for perioperative pain management in oncology. Bioactive phytochemicals—such as terpenoids, flavonoids, alkaloids, and polyphenols—exert multimodal pharmacological effects ...
Yuqin Tang, Zheng Luo, Xu Zhao, Yongqiang Zhang, Mingyang Sun, Jiaqiang Zhang   +5 more
wiley   +1 more source