Results 41 to 50 of about 662,098 (274)

Imprint of quantum gravity in the dimension and fabric of spacetime

open access: yes, 2017
We here conjecture that two much-studied aspects of quantum gravity, dimensional flow and spacetime fuzziness, might be deeply connected. We illustrate the mechanism, providing first evidence in support of our conjecture, by working within the framework ...
Amelino-Camelia, Giovanni   +2 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

La métaphore « inappropriée » : échec du partage sentimental et flou résultatif

open access: yesLexis: Journal in English Lexicology, 2010
Metaphors, unlike comparisons, may be perceived as impolite speech acts. This study explains why: I define metaphor as a linguistic utterance in which the speaker appropriates language, such an appropriation taking the risk of being considered as ...
Julie Neveux
doaj   +1 more source

Probabilistic fatigue estimation framework for aeroengine bladed discs with multiple fuzziness modeling

open access: yesJournal of Materials Research and Technology, 2023
To reduce the estimation errors of probabilistic fatigue lifetime caused by artificial cognitive factors, a probabilistic fatigue estimation framework with the consideration of multiple fuzziness (i.e., stress and strength) is proposed.
Yao-Wei Wang   +3 more
doaj   +1 more source

Fuzziness and Funds Allocation in Portfolio Optimization [PDF]

open access: yes, 2002
Each individual investor is different, with different financial goals, different levels of risk tolerance and different personal preferences. From the point of view of investment management, these characteristics are often defined as objectives and ...
Florentin Smar   +3 more
core  

A Domain Analysis to Specify Design Defects and Generate Detection Algorithms [PDF]

open access: yes, 2008
Quality experts often need to identify in software systems design defects, which are recurring design problems, that hinder development\ud and maintenance.
Duchien, Laurence   +3 more
core   +6 more sources

Whole‐Body Pattern of Muscle Degeneration and Progression in Sarcoglycanopathies

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize whole‐body intramuscular fat distribution pattern in patients with sarcoglycanopathies and explore correlations with disease severity, duration and age at onset. Methods Retrospective, cross‐sectional, multicentric study enrolling patients with variants in one of the four sarcoglycan genes who underwent whole‐body ...
Laura Costa‐Comellas   +39 more
wiley   +1 more source

On Fuzzy Concepts [PDF]

open access: yes, 2006
In this paper we try to combine two approaches. One is the theory of knowledge graphs in which concepts are represented by graphs. The other is the axiomatic theory of fuzzy sets (AFS). The discussion will focus on the idea of fuzzy concept. It will be
Hoede, C., Wang, Xin
core   +1 more source

Spectral dimension of a quantum universe [PDF]

open access: yes, 2010
In this paper, we calculate in a transparent way the spectral dimension of a quantum spacetime, considering a diffusion process propagating on a fluctuating manifold.
A. Smailagic   +4 more
core   +1 more source

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