Results 101 to 110 of about 15,918 (289)

Application of humanized mice in the safety experiments of antibody drugs

open access: yesAnimal Models and Experimental Medicine, EarlyView.
The graphical abstract of this review highlights the critical role of humanized mice in the safety evaluation of antibody drugs. First, the inherent immunogenicity of antibody drugs can lead to the production of antidrug antibodies and hypersensitivity reactions on repeated administration.
Zhimin Sun   +9 more
wiley   +1 more source

A multicriteria decision analysis framework for developing and evaluating coastal retreat policy

open access: yesIntegrated Environmental Assessment and Management, Volume 19, Issue 1, Page 83-98, January 2023., 2023
Abstract Managed retreat may be a necessity for coastal communities as sea levels rise due to climate change. Selecting the right policy decisions and timing is difficult given the vested interests of communities and stakeholder groups and requires careful balancing of the benefits and risks associated with each management alternative.
Tyler A. Skidmore, Jared L. Cohon
wiley   +1 more source

A fuzzy graph approach analysis for COVID-19 outbreak. [PDF]

open access: yesResults Phys, 2021
Hassan N   +6 more
europepmc   +1 more source

Roadmap to Nanomedical Applications: Nanotoxicology and In Vitro Guidelines for Lanthanide‐Doped Luminescence Nanothermometers

open access: yesAdvanced NanoBiomed Research, EarlyView.
Lanthanide‐based luminescence nanothermometry holds multifaceted potential for nanomedical applications, yet despite significant research advances, clinical translation of the engineered nanomaterials is still controversial and widely disputed. This is related to crucial nanotoxicological aspects that must be addressed at the preclinical level ...
Simona Premcheska   +2 more
wiley   +1 more source

Relationships among tissues, biofluids, and otolith selenium concentrations in wild female burbot (Lota lota)

open access: yesIntegrated Environmental Assessment and Management, EarlyView., 2023
Abstract In the Lake Koocanusa‐Kootenai River system (Montana, USA and British Columbia, Canada), selenium (Se) contamination has become an international concern and is suspected to contribute to the observed burbot (Lota lota) population collapse. Due to our limited ability to sample burbot in Lake Koocanusa for monitoring studies, we used a reference
Stephanie D. Graves   +6 more
wiley   +1 more source

Stimuli‐Configuring Anisotropic Soft Architectures towards Dynamic Manipulable Photonics

open access: yesAdvanced Physics Research, EarlyView.
This review covers stimuli‐responsive liquid crystal micro/nano‐structures, focusing on their properties, advancements, and applications in photonics. It discusses electric, light, temperature, and mechanical stimuli, highlighting innovative applications in optics, sensing, information processing and so on so forth, emphasizing liquid crystal ...
Xiaoqian Wang, Zhi‐Gang Zheng
wiley   +1 more source

Segmentation of cortical bone, trabecular bone, and medullary pores from micro‐CT images using 2D and 3D deep learning models

open access: yesThe Anatomical Record, EarlyView.
Abstract Computed tomography (CT) enables rapid imaging of large‐scale studies of bone, but those datasets typically require manual segmentation, which is time‐consuming and prone to error. Convolutional neural networks (CNNs) offer an automated solution, achieving superior performance on image data.
Andrew H. Lee   +3 more
wiley   +1 more source

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