Results 81 to 90 of about 103,546 (246)

Synergistic p53 Pathway Activation Through Sono‐Gene Therapy Induced by Ultrasound‐Triggered Theranostic Mesoporous Nanoparticles

Advanced Science, EarlyView.
Schematic representation of ultrasound‐mediated ICG/siCD24@MSN‐LCD from nanostructure to synergistic sono‐gene therapy. This nanoplatform targets ASGPR via the LCD shell, which dissociates to release loaded ICG and siCD24. The core mechanism involves ultrasound‐guided sonodynamic therapy by ICG and CD24 knockdown by siCD24, both activating the p53 axis
Yading Zhao, Lu Guo, Dandan Shi, Xiao Sun, Mengmeng Shang, Song Ning, Shuting Huang, Xiaoxuan Wang, Rui Liu, Yuye Fu, Suyun Li, Jie Li   +11 more
wiley   +1 more source

Inter-Calibration and Limb Correction of FY-3D/E MWTS for Long-Term Gridded Microwave Brightness Temperature Dataset

Remote Sensing
The Microwave Temperature Sounder-3 (MWTS-3) onboard the Chinese FengYun-3E (FY-3E) satellite is the third generation of Chinese microwave temperature sounder.
Xinlu Xia, Mingjian Zeng, Xiaochun Luo, Xiao Shi, Rongsheng Jiang, Xinyi Yuan, Xiaozhuo Sang, Fei Tang, Xu Xu   +8 more
doaj   +1 more source

Heat‐Suppressing Projection Two‐Photon Lithography Enables High‐Throughput Sub‐Micrometer Manufacturing of Biopolymer Hydrogels for Tissue Engineering

Advanced Science, EarlyView.
The iLEAP technique integrates high‐throughput two‐photon lithography with extrusion printing, bridging sub‐micrometer precision and macroscopic scaffold fabrication. By employing a low‐exothermic photoinitiator, it mitigates thermal damage to biopolymers and preserves bioactivity.
Qifeng Guan, Yanzhe Fu, Xiangyu Xu, Naitao Li, Sen Hou, Kai Wang, Yufan Wang, Jiakun Li, Ping Li, Jiebo Li, Lizhen Wang, Yubo Fan   +11 more
wiley   +1 more source

OLR anomalies of the Dezhou MS5.5 earthquake in Shandong Province based on FY-3E satellite data [PDF]

Based on the periodic variation of tidal forces, outgoing longwave radiation (OLR) data from the FY-3E satellite were used to analyze the daily variations of OLR from June 30 to August 30 in 2023 over a large area (17°N～55°N, 73°E～136°E) of the Chinese ...
Wei Ji, Jianyong Li, Yinxing Shao, Dan Yu, Weiyu Ma, Jun Liu   +5 more
core   +1 more source

GM‐CSF Promotes Neutrophil PD‐L1 Expression Through the VEGFR‐2/STAT6/CSF2 Signaling Axis in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
VEGFR‐2 signaling in OSCC activates Src–STAT6‐dependent CSF2 transcription, driving tumor‐derived GM‐CSF secretion. GM‐CSF programs neutrophils to express PD‐L1 through STAT5–mTOR/S6K signaling, suppressing cytotoxic CD8+ T cells. This pathway reveals a tumor–neutrophil immune checkpoint circuit that limits anti‐PD‐1 responsiveness in OSCC.
Fangxing Zhu, Yuanhe You, Yiyi Zhang, Yibin Dai, Xinyu Zhou, Yong Fu, Xi Lu, Yingying Huang, Zhihang Zhou, Ronghui Xia, Wutong Ju, Zhaoqi Yuan, Laiping Zhong, Tongchao Zhao   +13 more
wiley   +1 more source

Calibration of the Medium Energy Proton Detector of FY-3E

Chinese Journal of Space Science, 2023
Mengtan HAO, Shenyi ZHANG, Donghui HOU, Guohong SHEN, Huanxin ZHANG, Bo SU, Chaoping BAI, Ying SUN, Ping ZHOU, Wentao JI   +9 more
openaire   +1 more source

Multi‐Omics Integration Identifies a CDH3‐Associated Malignant Epithelial State and Immunosuppressive Niche to Predict Prognosis in Thymic Epithelial Tumors

Advanced Science, EarlyView.
Single‐cell, spatial, molecular, and pathology analyses identify a CDH3‐associated malignant epithelial state in thymic epithelial tumors. This state links stem‐like and EMT programs to M2 macrophage–rich immunosuppressive niches, genomic instability, poor survival, and drug vulnerability.
Yuntao Feng, Jingyu Chen, Lang Xia, Tao Wang, Yuzhou Wang, Lei Zhang, Guofang Zhao, Long Xu, Juemin Yu, Yunlang She, Junqi Wu, Yue Zhao, Chang Chen, Deping Zhao   +13 more
wiley   +1 more source

First PWV Retrieval Using MERSI‐LL Onboard FY‐3E and Cross Validation With Co‐Platform Occultation and Ground GNSS

Geophysical Research Letters
FY‐3E plays a vital role in the meteorological global earth observing system. Precipitable water vapor (PWV) is an essential parameter for the water cycle and global climate change.
Nan Jiang, Yuhao Wu, Song Li, Yan Xu, Yubo Wang, Tianhe Xu   +5 more
doaj   +1 more source

CUX1 directly binds to the ER-α promoter and is antagonized by Cat L inhibitor (Z-FY-CHO) or MSKE.

, 2019
(A) MCF-7 Neo and MCF-7 cells overexpressing Snail (MCF-7 Snail) or (C) MDA-MB-468 cells were utilized for ChIP analysis with anti-CUX1 antibody or goat IgG as a negative control to immunoprecipitate, and qRT-PCR with primers to ER-α promoter containing ...
Liza J. Burton (615553), Janae Sweeney (6569783), Nathan Bowen (3760717), Ohuod Hawsawi (3226491), Valerie Odero-Marah (3226500), Tamaro Hudson (3226497)   +5 more
core   +1 more source

Dual‐Organelle Secretome Conjugation and Organ‐Uptake Tracking (DuO‐SCOUT) Enables Deep and Sensitive Mapping of the Secreted Proteins

Advanced Science, EarlyView.
A novel dual‐organelle proximity labeling platform, DuO‐SCOUT, decodes the complex landscape of systemic organ‐organ communication by capturing both classical and unconventional secretomes. Application in metabolic models maps the adipose‐to‐brain secretory relay, identifying selective extra‐hypothalamic sites for adipose‐derived factors and expanding ...
Fenglian Yang, Rui Qian, Jiaxing Song, Xingqi Meng, Jin Young Kim, Kwok On Lai, Li Wang, Liang Zhang   +7 more
wiley   +1 more source