Results 41 to 50 of about 276,085 (274)

Local module identification in dynamic networks with correlated noise: the full input case [PDF]

, 2019
The identification of local modules in dynamic networks with known topology has recently been addressed by formulating conditions for arriving at consistent estimates of the module dynamics, typically under the assumption of having disturbances that are ...
Bottegal, Giulio, Dankers, Arne G., Hof, Paul M. J. Van den, Ramaswamy, Karthik R.   +3 more
core   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

ASV Multiple Sklerose aus Patientensicht – ein Fallbeispiel

Monitor Versorgungsforschung
Die Ambulante spezialfachärztliche Versorgung (ASV) soll Menschen mit seltenen Erkrankungen oder mit besonderen Krankheitsverläufen eine strukturierte, sektoren-übergreifende Versorgung gewährleisten. Eine entsprechende Rechtsgrundlage ist in § 116b Abs.
Dr. PH Patrick Ziech
doaj   +1 more source

Tumour necrosis factor-alpha gene polymorphisms in Iranian patients with biliary atresia

African Journal of Paediatric Surgery, 2014
Background: Biliary atresia (BA) is a progressive inflammatory destructive process of the bile ducts. This study evaluated the relationship between single-nucleotide polymorphisms in the promoter region of tumour necrosis factor-alpha (TNF-α) gene and ...
Nikou Fotouhi, Morteza Bonyadi, Zohreh Jahanafrooz, Nahid Ahmadian, Mahnaz Sadeghi-Shabestari, Saeid Aslanabadi, Robabeh Ghergherehchi, Milad Pormosavi, Mandana Rafeey   +8 more
doaj   +1 more source

Preparation and molten salts corrosion behavior of high-entropy (Ca,Sr,Ba)TMO3 (TM= Zr, Hf and Ta): Promising protecting materials of reference electrode for metal smelting through fused salts electrolysis

Corrosion Communications, 2021
The protecting materials of reference electrode with good corrosion resistance to molten salts play vital roles in realizing smelting of refractory and rare earth metals through fused salts electrolysis.
Shuaihang Qiu, Huimin Xiang, Fu-Zhi Dai, Hailong Wang, Yanchun Zhou   +4 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Das Verfahren der anwendungsbegleitenden Datenerhebung für die frühe Nutzenbewertung

Monitor Versorgungsforschung
Am 16. August 2019 trat das Gesetz für mehr Sicherheit in der Arzneimittelversorgung (GSAV) in Kraft. Es wurden Änderungen in § 35a SGB V vorgenommen, die es dem Gemeinsamen Bundesausschuss (G-BA) ermöglichen, bei Arzneimitteln zur Behandlung eines ...
Dr. rer. nat. Florian Jantschak, Dr. med. Katharina Wenzel-Seifert, Dr. rer. nat. Tilman Broicher, Dr. med. Maike Schier   +3 more
doaj   +1 more source

Content of interleukins-4, 6 and nuclear transcription factor NF-κB in children with atopic bronchial asthma depending on Ile50Val polymorphism of IL4RA gene, severity of the disease course and level of its control

Zaporožskij Medicinskij Žurnal, 2019
Many studies on polymorphic variants of cytokines genes indicate that their role in bronchial asthma development in children is still not fully understood. Aim.
V. M. Dudnyk, L. V. Moroz, N. V. Zaichko, O. V. Kutsak   +3 more
doaj   +1 more source

Core professionalism education in surgery: A systematic review [PDF]

, 2018
Background: Professionalism education is one of the major elements of surgical residency education. Aims: To evaluate the studies on core professionalism education programs in surgical professionalism education. Study Design: Systematic review.
Büke, Akile Sarıoğlu, Sayek, İ., Yılmaz, Y., Öztürkçü, Ö.S.K.   +3 more
core   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source