Results 51 to 60 of about 263,600 (280)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Seasonal variations of triterpene acid contents in Viscum album L. on typical host trees of Hyrcanian forests

Scientific Reports, 2023
Viscum album L. (mistletoe) is a semiparasitic plant of the Santalaceae family. A valuable group of bioactive compounds in mistletoe are triterpene acids (TTAs), which possess anti-inflammatory and anticancer properties.
Arina Soursouri, Seyed Mohsen Hosseini, Farnoosh Fattahi   +2 more
doaj   +1 more source

Aufgaben und Ziele des G-BA – AMNOG aus Sicht des G-BA

, 2011
[for full text, please go to the a.m. URL]
openaire   +2 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

„Eine Allianz der evidenzbasiert Entscheidenden gegen Populismus“

Monitor Versorgungsforschung
Im Doppel-Titelinterview zum Jahresstart 2024 mit „Monitor Versorgungsforschung“ diskutieren Prof. Josef Hecken, der unparteiische Vorsitzende des Gemeinsamen Bundesausschusses (G-BA), und Univ.-Prof. Dr. med.
Prof. Josef Hecken, Univ.-Prof. Dr. med. Wolfgang Hoffmann, Peter Stegmaier   +2 more
doaj   +1 more source

The Boolean algebra of Galois algebras

International Journal of Mathematics and Mathematical Sciences, 2003
Let B be a Galois algebra with Galois group G, Jg={b∈B|bx=g(x)b for all x∈B} for each g∈G, and BJg=Beg for a central idempotent eg, Ba the Boolean algebra generated by {0,eg|g∈G}, e a nonzero element in Ba, and He={g∈G|eeg=e}.
George Szeto, Lianyong Xue
doaj   +1 more source

Barium in coal and coal combustion products: Distribution, enrichment and migration

Energy Exploration & Exploitation, 2022
Coal triggering pollution caused by the emission of harmful substances in the process of coal combustion has been paid more and more attention. Barium is a ubiquitous heavy metal element in coal.
Huidi Hao, Minmin Zhang, Jinxi Wang, Zhiheng Fu, Panchal Balaji, Shuting Jiang   +5 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The Boolean algebra and central Galois algebras

International Journal of Mathematics and Mathematical Sciences, 2001
Let B be a Galois algebra with Galois group G, Jg={b∈B∣bx=g(x)b   for all   x∈B} for g∈G, and BJg=Beg for a central idempotent eg. Then a relation is given between the set of elements in the Boolean algebra (Ba,≤) generated by {0,eg∣g∈G} and a set of ...
George Szeto, Lianyong Xue
doaj   +1 more source