Results 101 to 110 of about 12,796 (278)
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Optimal Trade Policies for a Developing Country Under Uncertainty [PDF]
This paper investigates optimal trade policies for a developing small open economy which faces international price uncertainty. Trade taxes are used to finance provision of a public good, which enters the utility function of consumers.
Choi, E. Kwan, Lapan, Harvey E.
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Electronic Journal of Differential Equations, 2015 In applications it is common to arrive at a problem where the choice of an optimal domain is considered. One such problem is the one associated with the steady state reaction diffusion equation given by a semilinear elliptic equation with a monotone ...
Jesus Ildefonso Diaz, David Gomez-Castro
doaj
A study of unmanned mission opportunities to comets and asteroids [PDF]
Several unmanned multiple-target mission opportunities to comets and asteroids were studied. The targets investigated include Grigg-Skjellerup, Giacobini-Zinner, Tuttle-Giacobini-Kresak, Borrelly, Halley, Schaumasse, Geographos, Eros, Icarus, and Toro ...
Bjorkman, W. +2 more
core +1 more source
Designs efficiency for non-market valuation with choice modelling: how to measure it, what to report and why [PDF]
, 2007 We review the basic principles for the evaluation of design efficiency in discrete choice modelling with a focus on efficiency of WTP estimates from the multinomial logit model.
Rose, John M., Scarpa, Riccardo
core +2 more sources
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
SLM-Based Agentic AI with P-C-G: Optimized for Korean Tool Use
We propose a small-scale language model (SLM) based agent architecture, Planner-Caller-Generator (P-C-G), optimized for Korean tool use. P-C-G separates planning, calling, and generation by role: the Planner produces an initial batch plan with limited on-demand replanning; the Caller returns a normalized call object after joint schema-value validation;
Jeon, Changhyun +5 more
openaire +2 more sources
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Common Value Auctions with Return Policies [PDF]
This paper examines the role of return policies in common value auctions. We first characterize the unique symmetric equilibrium in first-price and second-price auctions with continuous signals and discrete common values when certain return policies are ...
Jun Zhang, Ruqu Wang
core