Results 81 to 90 of about 12,796 (278)

Variance heterogeneity in experimental design [PDF]

Statistical ...
Kleijnen, J.P.C.
core   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Multicriteria optimization of the composition, thermodynamic and strength properties of fly-ash as an additive in metakaolin-based geopolymer composites

Scientific Reports
This paper presents the construction of intelligent systems for selecting the optimum concentration of geopolymer matrix components based on ranking optimality criteria.
Van Su Le, Artem Sharko, Oleksandr Sharko, Dmitry Stepanchikov, Katarzyna Ewa Buczkowska, Petr Louda   +5 more
doaj   +1 more source

An Equivalence Theorem and A Sequential Algorithm for A-Optimal Experimental Designs on Manifolds

Axioms
Selecting input data points in the context of high-dimensional, nonlinear, and complex data in Riemannian space is challenging. While optimal experimental design theory is well-established in Euclidean space, its extension to Riemannian manifolds remains
Jingwen Zhang, Yaping Wang
doaj   +1 more source

Design Issues for Generalized Linear Models: A Review

, 2006
Generalized linear models (GLMs) have been used quite effectively in the modeling of a mean response under nonstandard conditions, where discrete as well as continuous data distributions can be accommodated.
Ghosh, Malay, Khuri, André I., Mukherjee, Bhramar, Sinha, Bikas K.   +3 more
core   +3 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Efficient design for willingness to pay in choice experiments: evidence from the field [PDF]

Efficient experimental designs offer the potential to reduce confidence intervals for parameters of interest in choice models, or to reduce required sample sizes.
Kerr, Geoffrey N., Sharp, Basil M.H.
core   +1 more source

Оптимальность планов полноблочных регрессионных экспериментов [PDF]

, 2012
В статье изучаются свойства оптимальности планов полноблочных экспериментов, которые могут использоваться для получения регрессионных моделей в случае двух независимых групп факторов.
Ловенецкая, Елена Ивановна
core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source