Results 91 to 100 of about 12,796 (278)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Numbers of center points appropriate to blocked response surface experiments [PDF]
Tables are given for the numbers of center points to be used with blocked sequential designs of composite response surface experiments as used in empirical optimum seeking. The star point radii for exact orthogonal blocking is presented. The center point
Holms, A. G.
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Information sharing and the stability of cooperation in research joint ventures [PDF]
The model studies information sharing and the stability of cooperation in cost reducing Research Joint Ventures (RJVs). In a three-stage game- theoretic framework, firms decide on participation in a RJV, information sharing along with R&D expenditures ...
Gamal Atallah
core +3 more sources
Arab Journal of Mathematical Sciences, 2014 In this paper, we introduce and study an implicit iterative method to approximate a common solution of split equilibrium problem and fixed point problem for a nonexpansive semigroup in real Hilbert spaces. Further, we prove that the nets generated by the
K.R. Kazmi, S.H. Rizvi
doaj +1 more source
International Journal of Scientific Research in Science, Engineering and Technology, 2018 Optimal design is a design which required in determining the points of variable factors that would be attempted to optimize the relevant information so that fulfilled the desired criteria. The optimal fulfillment criteria based on the information matrix of the selected model.
openaire +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Regularity of stable solutions to semilinear elliptic equations on Riemannian models
Advances in Nonlinear Analysis, 2015 We consider the reaction-diffusion problem -Δgu = f(u) in ℬR with zero Dirichlet boundary condition, posed in a geodesic ball ℬR with radius R of a Riemannian model (M,g).
Castorina Daniele, Sanchón Manel
doaj +1 more source
Optimal designs for smoothing splines [PDF]
In the common nonparametric regression model we consider the problem of constructing optimal designs, if the unknown curve is estimated by a smoothing spline.
Dette, Holger +2 more
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