Results 11 to 20 of about 381,873 (261)

Mas-Related G-Protein-Coupled Receptors: Emerging Roles in Neuropathic Pain [PDF]

Biomolecules
Mas-related G-protein-coupled receptors constitute a distinct family of GPCRs expressed in some subsets of sensory neurons and immune cells. Increasing evidence highlights their contribution to the modulation of nociceptive signaling and neuroimmune ...
Mario García-Domínguez
doaj   +2 more sources

Latest surface plasmon resonance advances for G protein-coupled receptors [PDF]

Journal of Pharmaceutical Analysis
G protein-coupled receptors (GPCRs) are a big family of membrane proteins which represent one of the main classes of drug targets. However, their investigation presents several challenges, among which their instability outside the membrane environment ...
Giulia De Soricellis, Enrica Calleri, Sofia Salerno, Gloria Brusotti, Sara Tengattini, Caterina Temporini, Gabriella Massolini, Francesca Rinaldi   +7 more
doaj   +2 more sources

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis [PDF]

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +2 more sources

Targeting G protein–coupled receptor kinases to G protein–coupled receptors

Current Opinion in Endocrine and Metabolic Research, 2021
G protein-coupled receptors (GPCRs) interact with three protein families following agonist binding: heterotrimeric G proteins, G protein-coupled receptor kinases (GRKs) and arrestins. GRK-mediated phosphorylation of GPCRs promotes arrestin binding to uncouple the receptor from G protein, a process called desensitization, and for many GPCRs, arrestin ...
Sarah M, Sulon, Jeffrey L, Benovic
openaire   +3 more sources

G-Protein-Coupled Receptors [PDF]

Journal of Biological Chemistry, 1998
G-protein-coupled receptors (GPCRs) constitute a huge family of membrane receptors to numerous hormones, neurotransmitters and diverse compounds. A large part of cardiovascular and neurological pharmacology is based upon the knowledge of these receptors and on the identification of molecules able to interfere with them, in an agonistic or antagonistic ...
openaire   +1 more source

Prediction of the coupling specificity of G protein coupled receptors to their G proteins [PDF]

Bioinformatics, 2001
Abstract G protein coupled receptors (GPCRs) are found in great numbers in most eukaryotic genomes. They are responsible for sensing a staggering variety of structurally diverse ligands, with their activation resulting in the initiation of a variety of cellular signalling cascades.
Steffen Möller, Jaak Vilo, Michael D. R. Croning   +2 more
openaire   +3 more sources

Lysophospholipid G Protein-coupled Receptors [PDF]

Journal of Biological Chemistry, 2004
The many biological responses documented for lysophospholipids that include lysophosphatidic acid and sphingosine 1-phosphate can be mechanistically attributed to signaling through specific G protein-coupled receptors. At least nine receptors have now been identified, and the total number is likely to be larger.
Brigitte, Anliker, Jerold, Chun
openaire   +2 more sources

Rules and mechanisms governing G protein coupling selectivity of GPCRs

Cell Reports, 2023
Summary: G protein-coupled receptors (GPCRs) convert extracellular stimuli into intracellular signaling by coupling to heterotrimeric G proteins of four classes: Gi/o, Gq, Gs, and G12/13.
Ikuo Masuho, Ryoji Kise, Pablo Gainza, Ee Von Moo, Xiaona Li, Ryosuke Tany, Hideko Wakasugi-Masuho, Bruno E. Correia, Kirill A. Martemyanov   +8 more
doaj   +1 more source

Neuropeptide G Protein-Coupled Receptors as Oncotargets

Frontiers in Endocrinology, 2018
Neuropeptide G protein-coupled receptors (GPCRs) are overexpressed on numerous cancer cells. In a number of tumors, such as small cell lung cancer (SCLC), bombesin (BB) like peptides and neurotensin (NTS) function as autocrine growth factors whereby they
Terry W. Moody, Irene Ramos-Alvarez, Robert T. Jensen   +2 more
doaj   +1 more source

Role of G-protein coupled receptors in cardiovascular diseases

Frontiers in Cardiovascular Medicine, 2023
Cardiovascular diseases (CVDs) are the leading cause of death globally, with CVDs accounting for nearly 30% of deaths worldwide each year. G-protein-coupled receptors (GPCRs) are the most prominent family of receptors on the cell surface, and play an ...
Yuanqiang Li, Boyu Li, Wei-Dong Chen, Wei-Dong Chen, Yan-Dong Wang   +4 more
doaj   +1 more source