Results 191 to 200 of about 393,484 (315)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Structural basis of GAIN domain autoproteolysis and cleavage-resistance in the adhesion G-protein coupled receptors. [PDF]

Nat Commun
Pohl F, Seufert F, Chung YK, Schick R, Kieslich B, Schöneberg T, Langenhan T, Hildebrand PW, Sträter N.   +8 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Adhesion G-Protein Coupled Receptors in Neurological and Psychiatric Disorders. [PDF]

J Psychiatr Brain Sci
Lee BH, Meyer CM, Speca DJ, Díaz E.
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

G Protein-Coupled Receptors in Irritable Bowel Syndrome: Mechanisms and Therapeutic Opportunities. [PDF]

Int J Mol Sci
Zhu Z, Liu Z, He Y, He X, Zheng W, Jiang M.   +5 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

G Protein-Coupled Receptors in Cerebrovascular Diseases: Signaling Mechanisms and Therapeutic Opportunities. [PDF]

Int J Mol Sci
Gu Q, Yao J, Sheng J, Liu D.
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: G protein-coupled receptors. [PDF]

Br J Pharmacol
Alexander SPH, Davenport AP, Kelly E, Gibb AJ, Mathie AA, Peach CJ, Veale EL, Armstrong JF, Faccenda E, Harding SD, Southan C, Davies JA, Abbracchio MP, Abraham GR, Agoulnik A, Alexander W, Al-Hosaini K, Bäck M, Baker JG, Barnes NM, Bathgate R, Beaulieu JM, Beck-Sickinger AG, Behrens M, Bennett KA, Bernstein KE, Bettler B, Birdsall NJM, Blaho VA, Bonaventure P, Boulay F, Bousquet C, Bräuner-Osborne H, Brown AJ, Burnstock G, Busnelli M, Caló G, Caruso V, Castaño JP, Catt KJ, Ceruti S, Chazot P, Chiang N, Chini B, Christopoulos A, Chun J, Cianciulli A, Civelli O, Clapp LH, Couture R, Cox HM, Csaba Z, Dahlgren C, Dautzenberg FM, Dent G, Douglas SD, Dournaud P, Dubocovich ML, Eguchi S, Escher E, Filardo EJ, Fong T, Forsman HF, Fumagalli M, Gainetdinov RR, Garelja ML, de Gasparo M, Gbahou F, Gerard C, Gershengorn M, Glass M, Gloriam DE, Gobeil F, Goodfriend TL, Goudet C, Grätz L, Gregory KJ, Gruber C, Gundlach AL, Hamann J, Hanson J, Hartman DS, Hauger RL, Hay DL, Heinemann A, Heitman L, Herr DR, Hollenberg MD, Holliday ND, Holst B, Horiuchi M, Hoyer D, Hunyady L, Husain A, IJzerman AP, Inagami T, Insel PA, Jacobson KA, Jacobson LH, Jensen RT, Jockers R, Jonnalagadda D, Karnik S, Kaupmann K, Kemp J, Kennedy C, Kihara Y, Kinsolving J, Kitazawa T, Kozielewicz P, Kreienkamp HJ, Kukkonen JP, Laishram L, Langenhan T, Langmead CJ, Larhammar D, Leach K, Lecca D, Lee JD, Leeman SE, Leprince J, Leurs R, Li XX, Liebscher I, Lolait SJ, Lupp A, Macrae R, Maguire JJ, Malfacini D, Manning M, Marangon D, Martemyanov K, Mazella J, McArdle CA, Melmed S, Michel MC, Miller LJ, Mitolo V, Mouillac B, Müller CE, Murphy PM, Nahon JL, Neubig RR, Ngo T, Norel X, Nyimanu D, O'Carroll AM, Offermanns S, Panaro MA, Parmentier M, Perry-Hauser N, Pertwee RG, Pin JP, Prossnitz ER, Qin HC, Quinn M, Raffaele S, Ramachandran R, Ray M, Reinscheid RK, Buzón AR, Rondard P, Rosenkilde MM, Rovati GE, Ruzza C, Sanger GJ, Scholz N, Schöneberg T, Schulte G, Schulz S, Segaloff DL, Serhan CN, Shukla AK, Singh KD, Smith CM, Smith NJ, Stäubert C, Stoddart LA, Sugimoto Y, Summers R, Tan VP, Thal DM, Thomas WW, Timmermans PBMWM, Tirupula K, Toll L, Tulipano G, Unal H, Unger T, Valant C, Vanderheyden P, Vaudry D, Vaudry H, Verbalis JG, Vilardaga JP, Walker CS, Wang JM, Ward DT, Wester HJ, Willars GB, Williams TL, Woodruff TM, Wu H, Yang C, Yao C, Ye RD, Zaidman N.   +206 more
europepmc   +1 more source