Results 221 to 230 of about 774,543 (406)

Mutagenesis Reveals Structure−Activity Parallels between Human A_2AAdenosine Receptors and Biogenic Amine G Protein-Coupled Receptors [PDF]

, 1997
Qiaoling Jiang, Brian X. Lee, Marc Glashofer, A. Michiel van Rhee, Kenneth A. Jacobson   +4 more
openalex   +1 more source

Endoglin mediates the tumor‐ and metastasis‐promoting traits of stromal myofibroblasts in human breast carcinomas

Molecular Oncology, EarlyView.
Carcinoma‐associated fibroblasts (CAFs) in tumors influence cancer progression. We identified endoglin (ENG) as a key factor in TGF‐β signaling in myofibroblastic CAFs (myCAFs), linked to poor breast cancer outcomes. Inhibiting ENG on myCAFs suppressed the TGF‐β‐Smad2/3 pathway, reducing primary tumor growth and metastasis.
Shoki Okubo, Yoshihiro Mezawa, Zixu Wang, Ahmet Acar, Yasuhiko Ito, Atsushi Takano, Yohei Miyagi, Tomoyuki Yokose, Toshinari Yamashita, Yataro Daigo, Takuya Shirakihara, Akira Orimo   +11 more
wiley   +1 more source

Remote Control of Neuronal Activity in Transgenic Mice Expressing Evolved G Protein-Coupled Receptors

Neuron, 2009
G. M. Alexander, Sarah C. Rogan, Atheir I. Abbas, Blaine N. Armbruster, Ying Pei, John A. Allen, R. Nonneman, J. Hartmann, S. Moy, M. Nicolelis, J. McNamara, B. Roth   +11 more
semanticscholar   +1 more source

G-Protein-Coupled Modulation of Presynaptic Calcium Currents and Transmitter Release by a GABA_BReceptor [PDF]

, 1998
Tomoyuki Takahashi, Yoshinao Kajikawa, Tetsuhiro Tsujimoto   +2 more
openalex   +1 more source

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source

G-Protein-Coupled Receptors in Chronic Kidney Disease Induced by Hypertension and Diabetes. [PDF]

Cells
Tang H, Li K, Shi Z, Wu J.
europepmc   +1 more source

G Protein-Coupled Receptors in Cell Signaling Transduction. [PDF]

Int J Mol Sci, 2023
Beer-Hammer S, Liebscher I.
europepmc   +1 more source

Reciprocal In Vivo Regulation of Myocardial G Protein–Coupled Receptor Kinase Expression by β-Adrenergic Receptor Stimulation and Blockade [PDF]

, 1998
Guido Iaccarino, Eric D. Tomhave, Robert J. Lefkowitz, Walter J. Koch   +3 more
openalex   +1 more source

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

Biased agonism of G protein-coupled receptors as a novel strategy for osteoarthritis therapy. [PDF]

Bone Res
Meng X, Qin L, Wang X.
europepmc   +1 more source