Results 241 to 250 of about 774,543 (406)

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

Molecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella, Giuseppina Comito, Luigi Ippolito, Erica Pranzini, Marta Iozzo, Giulia Gangarossa, Francesca Virgilio, Silvia Bua, Alessio Nocentini, Giada Sandrini, Nicla Lorito, Marina Bacci, Gabriella Nesi, Pietro Spatafora, Sergio Serni, Claudiu T. Supuran, Andrea Morandi, Paola Chiarugi, Elisa Giannoni   +18 more
wiley   +1 more source

Mechanisms of Peptide Agonist Dissociation and Deactivation of Adhesion G-Protein-Coupled Receptors. [PDF]

Biochemistry
Joshi K, Miao Y.
europepmc   +1 more source

Monoclonal antibodies reveal receptor specificity among G-protein-coupled receptor kinases. [PDF]

, 1996
Martin Oppermann, Marı́a A. Diversé-Pierluissi, Mark H. Drazner, Shanny L. Dyer, Neil J. Freedman, Karsten Peppel, Robert J. Lefkowitz   +6 more
openalex   +1 more source

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source

Astrocytic G Protein-Coupled Receptors in Drug Addiction. [PDF]

Engineering (Beijing)
Zinsmaier AK, Nestler EJ, Dong Y.
europepmc   +1 more source

G-Protein-Coupled Receptors in Astrocyte–Neuron Communication

Neuroscience, 2020
P. Kofuji, A. Araque
semanticscholar   +1 more source

Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation

Molecular Oncology, EarlyView.
Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides, Sara Cristobal‐Vargas, Cristina De Ramón, Elizabeta A. Rojas, Irena Misiewicz‐Krzeminska, Isabel Isidro, José Juan Pérez, Bruno Paiva, Noemi Puig, Miguel Alcoceba, María‐Victoria Mateos, Luis A. Corchete, Myriam Cuadrado, Norma C. Gutiérrez   +13 more
wiley   +1 more source

Covalent functionalization of G protein-coupled receptors by small molecular probes. [PDF]

RSC Chem Biol
Beerkens BLH, IJzerman AP, Heitman LH, van der Es D.   +3 more
europepmc   +1 more source

Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors

Nature, 2004
Weihai He, F. Miao, Daniel C.-H. Lin, R. Schwandner, Zhulun Wang, Jinhai Gao, Jin-Long Chen, H. Tian, L. Ling   +8 more
semanticscholar   +1 more source

Lipid-mediated Regulation of G Protein-coupled Receptor Kinases 2 and 3 [PDF]

, 1995
Shubhik DebBurman, Judy Ptasienski, Evan Boetticher, Jon W. Lomasney, Jeffrey Benovic, Marie Thérèse Hosey   +5 more
openalex   +1 more source