Results 251 to 260 of about 777,795 (407)

Mechanisms of Peptide Agonist Dissociation and Deactivation of Adhesion G-Protein-Coupled Receptors. [PDF]

Biochemistry
Joshi K, Miao Y.
europepmc   +1 more source

Microglia limit brain tumor development by restricting tumor cell proliferation and inducing T‐cell immunity

Molecular Oncology, EarlyView.
Microglia (BV2) and IL‐4‐treated BMDMs promote astrocytoma clustering and inhibit tumor growth, not shown in other macrophage cells. In vivo, microglial co‐implantation enhances CD8+ T cell infiltration, elevates Granzyme B, lowers circulating MDSCs, and extends survival only in immune‐competent mice, but not in immune‐deficient mice.
Tzu‐Chieh Sun, Ching‐Fang Yu, Sheng‐Yan Wu, Wei‐Chung Cheng, Chi‐Shiun Chiang, Fang‐Hsin Chen   +5 more
wiley   +1 more source

Astrocytic G Protein-Coupled Receptors in Drug Addiction. [PDF]

Engineering (Beijing)
Zinsmaier AK, Nestler EJ, Dong Y.
europepmc   +1 more source

Lipid-mediated Regulation of G Protein-coupled Receptor Kinases 2 and 3 [PDF]

, 1995
Shubhik DebBurman, Judy Ptasienski, Evan Boetticher, Jon W. Lomasney, Jeffrey Benovic, Marie Thérèse Hosey   +5 more
openalex   +1 more source

Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors

Nature, 2004
Weihai He, F. Miao, Daniel C.-H. Lin, R. Schwandner, Zhulun Wang, Jinhai Gao, Jin-Long Chen, H. Tian, L. Ling   +8 more
semanticscholar   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Covalent functionalization of G protein-coupled receptors by small molecular probes. [PDF]

RSC Chem Biol
Beerkens BLH, IJzerman AP, Heitman LH, van der Es D.   +3 more
europepmc   +1 more source

G proteins of the Gq family couple the H2 histamine receptor to phospholipase C. [PDF]

, 1996
Bernhard Kühn, Andrea Schmid, Christian Harteneck, Thomas Gudermann, G. Schultz   +4 more
openalex   +1 more source

A single gene mutation predicts response to immune checkpoint blockade in ovarian clear cell carcinoma

Molecular Oncology, EarlyView.
Loss‐of‐function mutations in the scaffold subunit of protein phosphatase 2A (PP2A), PPP2R1A, sensitize ovarian clear cell carcinoma to immune checkpoint blockade (ICB) by enhancing the interferon gamma response and promoting antitumor immune cell infiltration.
Matheus Henrique Dias, René Bernards
wiley   +1 more source

Adhesion G protein-coupled receptors are activated by exposure of a cryptic tethered agonist

Proceedings of the National Academy of Sciences of the United States of America, 2015
Hannah M. Stoveken, A. Hajduczok, Lei Xu, G. Tall   +3 more
semanticscholar   +1 more source