Results 211 to 220 of about 39,406 (258)

Interplay of replication stress response and immune microenvironment in high-grade serous ovarian cancer. [PDF]

Front Cell Dev Biol
Venegas L, Lheureux S.
europepmc   +1 more source

Bora, CEP192 and Cenexin activate different Plk1 pools and regulate distinct cell and centrosome cycle transitions

Dwivedi D, Borges C, Harry D, Cirillo L, Meraldi P.   +4 more
europepmc   +2 more sources

DNA Damage and Repair in Thyroid Physiology and Disease.

Endocr Rev
Arczewska KD, Sys D, Nilsen HL, Piekiełko-Witkowska A.   +3 more
europepmc   +1 more source

Total Synthesis of the G2/M DNA Damage Checkpoint Inhibitor Psilostachyin C

The Journal of Organic Chemistry, 2011
A concise total synthesis of the G2/M DNA damage checkpoint inhibitor psilostachyin C is reported using a 1,4-addition-aldol condensation-ring-closing metathesis (RCM) strategy. Initial biological studies indicate that psilostachyin C could enhance the sensitivity of the HeLa cell toward camptothecin (CPT) treatment via the activation of the caspase-3 ...
Li Chao, Shanghui Tu, Shuguang Wen, Shan Li, Junbiao Chang, Feng Shao, Xiaoguang Lei   +6 more
semanticscholar   +4 more sources

Ascorbic acid-dehydroascorbate induces cell cycle arrest at G2/M DNA damage checkpoint during oxidative stress

Environmental and Molecular Mutagenesis, 1999
Reactive oxygen species induce cellular damage and have been implicated as mediators for cellular signaling pathways. However, a linkage between the cellular redox status and cell cycle progression has not been demonstrated. We previously demonstrated, using the Chinese hamster ovary cell line AS52, that the cytotoxic and mutagenic effects of oxidative
Gautam N. Bijur, Bruce Briggs, Charles L. Hitchcock, Marshall V. Williams   +3 more
semanticscholar   +4 more sources

BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage

Nature Genetics, 2002
The breast cancer tumor-suppressor gene, BRCA1, encodes a protein with a BRCT domain-a motif that is found in many proteins that are implicated in DNA damage response and in genome stability. Phosphorylation of BRCA1 by the DNA damage-response proteins ATM, ATR and hCds1/Chk2 changes in response to DNA damage and at replication-block checkpoints ...
Ronit I. Yarden, Sherly Pardo-Reoyo, Magda Sgagias, Kenneth H. Cowan, Lawrence C. Brody   +4 more
openalex   +3 more sources

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Genistein induces G2/M cell cycle arrest and apoptosis of human ovarian cancer cells via activation of DNA damage checkpoint pathways

Cell Biology International, 2009
AbstractGenistein is a major isoflavonoid in dietary soybean, commonly consumed in Asia. Genistein exerts inhibitory effects on the proliferation of various cancer cells and plays an important role in cancer prevention. However, the molecular and cellular mechanisms of genistein on human ovarian cancer cells are still little known.
G. Ouyang, L. Yao, Kai Ruan, G. Song, Y. Mao, S. Bao   +5 more
semanticscholar   +4 more sources