Results 231 to 240 of about 57,844 (267)

Impeding the NHEJ Pathway for Overcoming Radioresistance in the Context of Precision Radiotherapy of Cancer. [PDF]

Pharmaceutics
Niculae DA, Șerban RM, Niculae D, Drăgănescu D.   +3 more
europepmc   +1 more source

Synthetic lethality and DNA damage response targeting in cancer stem cells: a comprehensive review. [PDF]

Discov Oncol
Sayed U, Abdulsahib WK, Jasim IK, Malathi H, Nayak PP, Alex Anand D, Mukherjee G, Sinha A, Eshkaraev S.   +8 more
europepmc   +1 more source

Genome-wide screen reveals dependence of break induced replication on several distinct checkpoints. [PDF]

Nat Commun
Liu L, Lee RS, Twarowski JM, Emagbetere T, Thomas J, Wells JM, Seuferer GJ, Lobachev K, Malkova A.   +8 more
europepmc   +1 more source

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Total Synthesis of the G2/M DNA Damage Checkpoint Inhibitor Psilostachyin C

The Journal of Organic Chemistry, 2011
A concise total synthesis of the G2/M DNA damage checkpoint inhibitor psilostachyin C is reported using a 1,4-addition-aldol condensation-ring-closing metathesis (RCM) strategy. Initial biological studies indicate that psilostachyin C could enhance the sensitivity of the HeLa cell toward camptothecin (CPT) treatment via the activation of the caspase-3 ...
Chao, Li, Shanghui, Tu, Shuguang, Wen, Shan, Li, Junbiao, Chang, Feng, Shao, Xiaoguang, Lei   +6 more
openaire   +2 more sources

BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage

Nature Genetics, 2002
The breast cancer tumor-suppressor gene, BRCA1, encodes a protein with a BRCT domain-a motif that is found in many proteins that are implicated in DNA damage response and in genome stability. Phosphorylation of BRCA1 by the DNA damage-response proteins ATM, ATR and hCds1/Chk2 changes in response to DNA damage and at replication-block checkpoints ...
Ronit I, Yarden, Sherly, Pardo-Reoyo, Magda, Sgagias, Kenneth H, Cowan, Lawrence C, Brody   +4 more
openaire   +2 more sources

Serine–Threonine Kinase 38 regulates CDC25A stability and the DNA damage-induced G2/M checkpoint

Cellular Signalling, 2015
Cells respond to DNA damage by activating protein kinase-mediated signaling pathways that promote cell-cycle arrest, DNA repair, or apoptosis. A key regulator of cell-cycle arrest is the CDC25A (cell division cycle 25 homologue A) phosphatase. CDC25A normally plays a pivotal role in regulating the G1/S and G2/M transitions by dephosphorylating and ...
Takemichi Fukasawa, Atsushi Enomoto, Kiyoshi Miyagawa   +2 more
openaire   +2 more sources

Ascorbic acid-dehydroascorbate induces cell cycle arrest at G2/M DNA damage checkpoint during oxidative stress

Environmental and Molecular Mutagenesis, 1999
Reactive oxygen species induce cellular damage and have been implicated as mediators for cellular signaling pathways. However, a linkage between the cellular redox status and cell cycle progression has not been demonstrated. We previously demonstrated, using the Chinese hamster ovary cell line AS52, that the cytotoxic and mutagenic effects of oxidative
G N, Bijur, B, Briggs, C L, Hitchcock, M V, Williams   +3 more
openaire   +2 more sources

ΔNp73α compromises G2/M checkpoint inducing genomic instability in response to DNA damage

2015
Deregulation of the cell cycle progression is a common feature of tumor cells and one of the driving forces in tumorigenesis, mostly by leading to unscheduled proliferation and genomic instability. The canonical p53 protein (p53α) and its relative p73 are shown to have various roles in cell cycle regulation in stress conditions, especially as a part of
Slade, Neda, Zorić, Arijana, Horvat, Anđela   +2 more
openaire   +2 more sources

Estrogen receptor beta decreases survival of p53-defective cancer cells after DNA damage by impairing G2/M checkpoint signaling

Breast Cancer Research and Treatment, 2010
Estrogen receptor beta (ERβ) inhibits proliferation in different cellular systems by regulating components of the cell cycle machinery. Eukaryotic cells respond to DNA damage by arresting in G1, S, or G2 phases of the cell cycle to initiate DNA repair. Most tumor cells due to disruptions in the p53-dependent G1 pathway are dependent on S-phase and G2/M
Christoforos G. Thomas, Anders Strom, Karolina Lindberg, Jan-Ake Gustafsson   +3 more
openaire   +1 more source