Results 241 to 250 of about 57,844 (267)

Genistein induces G2/M cell cycle arrest and apoptosis of human ovarian cancer cells via activation of DNA damage checkpoint pathways

Cell Biology International, 2009
AbstractGenistein is a major isoflavonoid in dietary soybean, commonly consumed in Asia. Genistein exerts inhibitory effects on the proliferation of various cancer cells and plays an important role in cancer prevention. However, the molecular and cellular mechanisms of genistein on human ovarian cancer cells are still little known.
Ouyang, Gaoliang, Yao, Luming, Ruan, Kai, Song, Gang, Mao, Yubin, Bao, Shideng   +5 more
openaire   +3 more sources

PARP-1 inhibitor sensitizes arsenic trioxide in hepatocellular carcinoma cells via abrogation of G2/M checkpoint and suppression of DNA damage repair

Chemico-Biological Interactions, 2015
Arsenic trioxide (ATO) is successfully used to treat hematological malignancies. However, the clinical application of the agent in solid tumors is largely limited by its dose-dependent toxicity which results from the high intrinsic resistance of the cancer cells.
Qingying, Luo, Yang, Li, Jianjun, Deng, Zunzhen, Zhang   +3 more
openaire   +2 more sources

The BRCA1 ring domain is essential for DNA damage repair and G2/M checkpoint activation

2014
The BRCA1 (breast cancer 1, early onset) tumor suppressor gene is involved in a variety of cellular pathways, and is an essential factor for normal DNA repair by homologous recombination. The BRCA1 protein has a number of conserved domains, including a coiled-coil domain, two BRCT domains and an N-terminal RING (Really Interesting New Gene) domain ...
openaire   +1 more source

­­­­A Novel Pipeline to Elucidate the Adaptation Response to the G2/M DNA Damage Checkpoint

SSRN Electronic Journal, 2022
Ambra Dondi, Sara Spreafico, Rosella Visintin   +2 more
openaire   +1 more source

c-Abl Phosphorylates Plk1 in Facilitating DNA Damage-Induced G2/M Checkpoint Release with a Trade-off of Micronuclei Formation

AbstractDNA double-strand breaks (DSBs) pose a critical threat to cellular proliferation and genomic integrity. Upon genotoxic stress, the DNA damage response (DDR) rapidly activates repair pathways and halts cell cycle progression through checkpoint activation.
Victoria Meltser, Merav Ben-Yehoyada, Julia Adler, Nina Reuven, Yosef Shaul   +4 more
openaire   +1 more source

374: c-Abl tyrosine kinase regulates recovery from the G2-M DNA damage induced checkpoint

European Journal of Cancer, 2014
V. Meltser, N. Reuven, Y. Shaul
openaire   +1 more source

Circulating tumor DNA in advanced solid tumors: Clinical relevance and future directions

Ca-A Cancer Journal for Clinicians, 2021
Michael L Cheng, Heather A Parsons, Atish D Choudhury   +2 more
exaly  

Checking on DNA damage in S phase

Nature Reviews Molecular Cell Biology, 2004
Jiri Bartek
exaly  

The MRE11 complex: at the crossroads of DNA repair and checkpoint signalling

Nature Reviews Molecular Cell Biology, 2002
Stephen Philip Jackson, John Gurdon
exaly  

A review of cancer immunotherapy toxicity

Ca-A Cancer Journal for Clinicians, 2020
Lucy Boyce Kennedy
exaly