Results 61 to 70 of about 1,157,795 (274)

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

No asymmetric outflows from Sagittarius A* during the pericenter passage of the gas cloud G2

, 2015
The gas cloud G2 falling toward Sagittarius A* (Sgr A*), the supermassive black hole at the center of the Milky Way, is supposed to provide valuable information on the physics of accretion flows and the environment of the black hole.
Bertarini, A., Bremer, M., de Vicente, P., Kim, J. -Y., Kino, M., Krichbaum, T. P., Park, J. -H., Trippe, S.   +7 more
core   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

Candida albicans Biofilm Heterogeneity and Tolerance of Clinical Isolates: Implications for Secondary Endodontic Infections

Antibiotics, 2019
Aim: Endodontic infections are caused by the invasion of various microorganisms into the root canal system. Candida albicans is a biofilm forming yeast and the most prevalent eukaryotic microorganism in endodontic infections.
Om Alkhir Alshanta, Suror Shaban, Christopher J Nile, William McLean, Gordon Ramage   +4 more
doaj   +1 more source

G2 checkpoint control and G2 chromosomal radiosensitivity in cancer survivors and their families [PDF]

Mutagenesis, 2010
Significant inter-individual variation in G(2) chromosomal radiosensitivity, measured as radiation-induced chromatid-type aberrations in the subsequent metaphase, has been reported in peripheral blood lymphocytes of both healthy individuals and a range of cancer patients.
Kevin K, Cadwell, Gillian B, Curwen, E Janet, Tawn, Jeanette F, Winther, John D, Boice   +4 more
openaire   +2 more sources

3D AMR hydrosimulations of a compact source scenario for the Galactic Centre cloud G2

, 2017
The nature of the gaseous and dusty cloud G2 in the Galactic Centre is still under debate. We present three-dimensional hydrodynamical adaptive mesh refinement (AMR) simulations of G2, modeled as an outflow from a "compact source" moving on the observed ...
Ballone, A., Burkert, A., Eisenhauer, F., Genzel, R., George, E. M., Gillessen, S., Habibi, M., Ott, T., Pfuhl, O., Plewa, P. M., Schartmann, M.   +10 more
core   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Immunotherapy of Crohn's disease

Mediators of Inflammation, 1998
Although the initiating events of Crohn's disease are unknown, models of experimental colitis have provided new insights in the immunologically mediated pathways of mucosal inflammation.
C. van Montfrans, L. Camoglio, S. J. H. van Deventer   +2 more
doaj   +1 more source

Filling the Void: An Optimized Polymicrobial Interkingdom Biofilm Model for Assessing Novel Antimicrobial Agents in Endodontic Infection

Microorganisms, 2020
There is a growing realization that endodontic infections are often polymicrobial, and may contain Candida spp. Despite this understanding, the development of new endodontic irrigants and models of pathogenesis remains limited to mono-species biofilm ...
Sumaya Abusrewil, Jason L. Brown, Christopher D. Delaney, Mark C. Butcher, Ryan Kean, Dalia Gamal, J. Alun Scott, William McLean, Gordon Ramage   +8 more
doaj   +1 more source