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Agonistic and antagonistic properties of CD40 mAb G28-5 are dependent on binding valency.

Circulatory shock, 1995
CD40 functional responses can be triggered by binding of mAb G28-5. Here we show that G28-5 induces partial CD40 responses and functions as a partial antagonist of natural CD40 ligand, gp39, by preventing gp39 binding. Fab fragments of G28-5 retain inhibitory activity but lose crosslinking-dependent stimulatory activity.
J A, Ledbetter +4 more
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G28(P) Wipe and wait: improving skin cleansing and line access technique to reduce serious blood stream infections in a neonatal intensive care setting

QUALITY IMPROVEMENT; EMBEDDING A CULTURE OF QUALITY IMPROVEMENT, 2019
Background Central lines are a vital component of ongoing care in the neonatal intensive care unit (NICU). Central line associated bloodstream infection (CLABSI) is a leading source of sepsis in the NICU setting, with up to 20% mortality. Aim We aimed to achieve significant reduction in the number of positive blood culture and CLABSI events in a ...
HE Groves, R Bates, A Walker
openaire +1 more source

Agonistic activity of a CD40-specific single-chain Fv constructed from the variable regions of mAb G28-5.

Critical reviews in immunology, 1998
A single-chain Fv (sFv) was expressed from the variable regions of the CD40-specific mAb G28-5. The molecule bound CD40 with a high affinity (2.2 nM) and was a monomer in solution. Surprisingly, G28-5 sFv was a potent CD40 agonist that rapidly crosslinked CD40 on the cell surface but did not crosslink CD40-Ig in solution.
J A, Ledbetter +14 more
openaire +1 more source

G28

2022
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G28

2021
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G28 Psychosocial interventions for the treatment of functional abdominal pain disorders in children: a systematic review and meta-analysis