Results 11 to 20 of about 24,323 (182)

HGG-40. UNRAVELING THE IMMUNOLOGIC VULNERABILITIES OF DIFFUSE HEMISPHERIC GLIOMA, H3 G34-MUTANT [PDF]

Neuro Oncol
BACKGROUND Insights into the pathogenesis of diffuse hemispheric glioma, H3 G34-mutant (DHG-G34), an incurable high-grade glioma, have opened new therapeutic possibilities.
C. Chan, Nina Hofmann, Mareike Roscher, R. Euler-Lange, Kevin Steimel, Mathea Fransisca, Alessia Cais, Ivana Dokic, David T. W. Jones, Jürgen Burhenne, Ina Kurth, Stefan M. Pfister, Marc Zuckermann, C. Crowell, J. Bennett, P. Bandopadhayay, D. Sturm, Adam L. Green, Mary V Macneil, M. Vanan, Valérie Larouche, Samuele Renzi, B. Imber, Jacquelyn Jones, S. Perreault, D. Mata-Mbemba, Charlotte Feddersen, Olivia Vizzini, M. Zápotocký, Sylvia Cheng, Rebecca A Harrison, Aimee Popovacki, D. Klawinski, J. Hansford, Sarah Lapointe, Romain Cayrol, N. Mankuzhy, Christina Coleman, Mariah L Wright-Nadkarni, R. Salloum, M. Karajannis, C. Hawkins, Keith L. Ligon, N. Jabado, C. Erker, Krishnakumar Madhavan, Sahiti Donthula, Lays Faye M Walker, Martin Sobral, Ilango Balakrishnan, Angela M Pierce, S. Karam, Natalie J Serkova, S. Venkataraman, Nathan A. Dahl, Rebecca D. Haase, L. Kilburn, M. Filbin, Lame Balikani, Yasin Yilmaz, Emily Mattera, Jeffrey R. Leonard, Marco Leung, Karen Tsuchiya, K. Schieffer, Yassmine M N Akkari, Allison McEnroe, Aaron S McAllister, Catherine Cottrell, Elaine R Mardis, M. Fouladi, Sara Khan, D. Boue   +72 more
europepmc   +5 more sources

Imaging features and consideration of progression pattern of diffuse hemispheric gliomas, H3 G34-mutant. [PDF]

Acta Neuropathol Commun
Diffuse hemispheric glioma H3 G34-mutant (DHG) has been identified as a distinct pediatric-type high-grade glioma, according to the World Health Organization (WHO) classification of central nervous system tumors. Widely accepted treatment options include
Kibe Y, Chalise L, Ohka F, Motomura K, Nakahara N, Aoki K, Deguchi S, Shiba Y, Takeuchi K, Iwami K, Yamaguchi J, Shimizu H, Maeda S, Takido Y, Yamamoto R, Okuno Y, Sakai A, Karube K, Saito R.   +18 more
europepmc   +7 more sources

Characteristics of diffuse hemispheric gliomas, H3 G34-mutant in adults [PDF]

Neuro-Oncology Advances, 2021
Background Diffuse hemispheric gliomas, H3 G34-mutant (DHG H3G34-mutant) constitute a distinct type of aggressive brain tumors. Although initially described in children, they can also affect adults.
T. Picart, M. Barritault, D. Poncet, L. Berner, C. Izquierdo, E. Tabouret, D. Figarella-Branger, A. Idbaih, F. Bielle, V. Bourg, F. Vandenbos, E. Moyal, E. Uro-Coste, J. Guyotat, J. Honnorat, M. Gabut, D. Meyronet, F. Ducray   +17 more
semanticscholar   +7 more sources

The clinical and molecular landscape of diffuse hemispheric glioma, H3 G34-mutant. [PDF]

Neuro Oncol
Background Diffuse hemispheric glioma, histone 3 (H3) G34-mutant, has been newly defined in the 2021 World Health Organization (WHO) classification of central nervous system tumors. Here we sought to define the prognostic roles of clinical, neuroimaging,
Le Rhun E, Bink A, Felsberg J, Gramatzki D, Brandner S, Benhamida JK, Wick A, Tonn JC, Mohme M, Tabatabai G, Capper D, Snuderl M, Razis E, Ronellenfitsch MW, Neidert N, Ng HK, Pohl U, Bale T, Quach S, Rieger D, Schüller U, Onken J, Drüschler K, Maurage CA, Regli L, Healy E, Graham M, Hortobagyi T, Paine S, Bridges L, Lausova T, Medici V, Sievers P, Schrimpf D, Wick W, Sahm F, Reifenberger G, von Deimling A, Weller M.   +38 more
europepmc   +5 more sources

Neuroimaging features of diffuse hemispheric glioma, H3 G34‐mutant: A case series and systematic review [PDF]

Journal of Neuroimaging, 2021
Diffuse hemispheric gliomas, H3 G34‐mutant (DHGs‐G34m), are newly recognized malignant brain tumors characterized by histone gene mutations. However, the neuroradiologic characteristics of these tumors require elucidation.
R. Kurokawa, A. Baba, M. Kurokawa, Emile S. Pinarbasi, Naohiro Makise, Y. Ota, John Kim, A. Srinivasan, T. Moritani   +8 more
semanticscholar   +5 more sources

G34, another connection between MYCN and a pediatric tumor. [PDF]

Cancer Discovery, 2013
Abstract Summary: Recurrent mutations in H3F3A at K27 and G34 are frequent in pediatric glioblastoma, but it is unclear how these mutations promote tumorigenesis. In this issue of Cancer Discovery, Bjerke and colleagues identify mutations at G34 in H3F3A that result in elevated expression of MYCN as a potential mechanism in gliomagenesis.
Miller Huang, W. Weiss
semanticscholar   +6 more sources

G34 Integrating elements of undergraduate curriculum learning [PDF]

Archives of Disease in Childhood, 2015
Rapidly advancing practice and recognition of nursing, midwifery and medicine as a vital interrelated workforce, implies a need for a variety of curricula opportunities. This project addresses the challenge for healthcare educators to widen student engagement and participation through inter-professional education by creating learning environments ...
Angela H. Bell, D. Corkin, C. Moorhead, A. Devlin   +3 more
semanticscholar   +3 more sources

Pediatric Hemispheric High-Grade Gliomas and H3.3-G34 Mutation: A Review of the Literature on Biological Features and New Therapeutic Strategies. [PDF]

Genes (Basel)
Pediatric high-grade glioma (pHGG) encompasses a wide range of gliomas with different genomic, epigenomic, and transcriptomic features. Almost 50% of pHGGs present a mutation in genes coding for histone 3, including the subtype harboring the H3.3-G34 ...
Bonada M, Pittarello M, De Fazio E, Gans A, Alimonti P, Slika H, Legnani F, Di Meco F, Tyler B.   +8 more
europepmc   +4 more sources

H3.3-G34 mutations impair DNA repair and promote cGAS/STING-mediated immune responses in pediatric high-grade glioma models [PDF]

Journal of Clinical Investigation, 2022
Pediatric high-grade gliomas (pHGGs) are the leading cause of cancer-related deaths in children in the USA. Sixteen percent of hemispheric pediatric and young adult HGGs encode Gly34Arg/Val substitutions in the histone H3.3 (H3.3-G34R/V).
S. Haase, K. Banerjee, Anzar A. Mujeeb, Carson S. Hartlage, F. Nunez, Felipe J. Núñez, Mahmoud S. Alghamri, Padma Kadiyala, S. Carney, Marcus N Barissi, Ayman W. Taher, Emily K. Brumley, Sarah Thompson, Justin T. Dreyer, Caitlin T. Alindogan, M. Garcia-Fabiani, A. Comba, S. Venneti, V. Ravikumar, C. Koschmann, A. Carcaboso, M. Vinci, A. Rao, Jennifer S. Yu, P. Lowenstein, M. Castro   +25 more
semanticscholar   +2 more sources

Epigenetics to clinicopathological features: a bibliometric analysis of H3 G34-mutant diffuse hemispheric glioma literature. [PDF]

Childs Nerv Syst
Pediatric-type diffuse high-grade gliomas are the leading cause of cancer-related morbidity and mortality in children. More than 30% of diffuse hemispheric gliomas (DHG) in adolescents harbor histone H3 G34 mutations and are recognized by the World Health Organization as a distinct tumor entity.
Roach JT, Riviere-Cazaux C, Wells BA, Boop FA, Daniels DJ.   +4 more
europepmc   +4 more sources