Results 11 to 20 of about 22,293 (179)

H3 G34-mutant high-grade glioma [PDF]

Brain Tumor Pathology, 2020
H3F3A G34 (H3.3 G34)-mutant high-grade gliomas (HGG) are rare, and newly recognized infiltrating gliomas of the cerebral hemisphere. Here, we report the clinicopathological and molecular characteristics of four H3.3 G34-mutant gliomas in terms of its biological behavior compared to those of glioblastomas (GBMs) and H3 K27M-mutant diffuse midline ...
Ka Young Lim, Jae Kyung Won, Chul-Kee Park, Seung-Ki Kim, Seung Hong Choi, Taemin Kim, Hongseok Yun, Sung-Hye Park   +7 more
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MPC-5 Characteristics of H3 G34-mutant gliomas [PDF]

Neuro-Oncology Advances, 2021
Abstract Introduction: Diffuse hemispheric gliomas, H3 G34-mutant (DHG H3G34-mutant) are newly recognized infiltrating gliomas of the cerebral hemispheres of pediatric and young adult patients. We experienced 6 DHG H3G34-mutant cases. In this study, we describe the clinical, radiological and pathological characteristics of these cases.
Kibe, Yuji, Ohka, Fumiharu, Motomura, Kazuya, Aoki, Kosuke, Maeda, Sachi, Hirano, Masaki, Nishikawa, Tomohide, Yamaguchi, Junya, Yamazaki, Shintaro, Natsume, Atsushi, Saito, Ryuta   +10 more
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cIMPACT-NOW update 11: Proposal on adaptation of diagnostic criteria for IDH- and H3-wildtype diffuse high-grade gliomas and for posterior fossa ependymal tumors. [PDF]

Brain Pathol
Abstract The Consortium to Inform Molecular and Practical Approaches to Central Nervous System Tumor Taxonomy (cIMPACT‐NOW) updates provide guidelines for the diagnosis of central nervous system (CNS) tumors and suggestions for future World Health Organization (WHO) classification.
Wesseling P, Capper D, Reifenberger G, Sarkar C, Hawkins C, Perry A, Kleinschmidt-DeMasters B, Komori T, Paulus W, Santosh V, van den Bent M, Weller M, Pfister SM, Tabori U, Figarella-Branger D, Orr BA, Louis DN.   +16 more
europepmc   +2 more sources

Genomic Profiling of Pediatric Solid Tumors With a Dual DNA/RNA Panel: JCCG-TOP2 Study. [PDF]

Cancer Sci
In the JCCG‐TOP2 nationwide pediatric cancer genomic profiling study, 204 patients' tumors and peripheral blood from 50 institutions across Japan were successfully analyzed using a dual DNA/RNA panel. A total of 147 (72%) had potentially actionable findings, including diagnostic, prognostic, and therapeutic findings in 111 (54%), 61 (30%), and 64 (31%),
Tao K, Yoshioka T, Kato M, Komatsu K, Tsujimoto S, Sakamoto K, Tanimura K, Sugiyama M, Sekiguchi M, Nakano Y, Otani Y, Yatabe Y, Yoshida A, Okita H, Hirato J, Kohashi K, Tanaka Y, Kohsaka S, Kubo T, Sunami K, Hirata M, Tsutsumi S, Aburatani H, Koh K, Hirayama M, Karakawa S, Terashita Y, Fujisaki H, Yagi T, Yoneda A, Mochizuki S, Shichino H, Suzuki T, Takimoto T, Ichimura K, Ogawa C, Matsumoto K, Ichikawa H, Kato M.   +38 more
europepmc   +2 more sources

Characteristics of diffuse hemispheric gliomas, H3 G34-mutant in adults [PDF]

Neuro-Oncology Advances, 2021
Abstract Background Diffuse hemispheric gliomas, H3 G34-mutant (DHG H3G34-mutant) constitute a distinct type of aggressive brain tumors. Although initially described in children, they can also affect adults.
Thiébaud Picart, Marc Barritault, Delphine Poncet, Lise-Prune Berner, Cristina Izquierdo, Emeline Tabouret, Dominique Figarella-Branger, Ahmed Idbaïh, Franck Bielle, Véronique Bourg, Fanny Burel Vandenbos, Elizabeth Cohen-Jonathan Moyal, Emmanelle Uro-Coste, Jacques Guyotat, Jérôme Honnorat, Mathieu Gabut, David Meyronet, François Ducray   +17 more
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The clinical and molecular landscape of diffuse hemispheric glioma, H3 G34-mutant. [PDF]

Neuro Oncol
Abstract Background Diffuse hemispheric glioma, histone 3 (H3) G34-mutant, has been newly defined in the 2021 World Health Organization (WHO) classification of central nervous system tumors. Here we sought to define the prognostic roles of clinical, neuroimaging, pathological, and molecular features ...
Le Rhun E, Bink A, Felsberg J, Gramatzki D, Brandner S, Benhamida JK, Wick A, Tonn JC, Mohme M, Tabatabai G, Capper D, Snuderl M, Razis E, Ronellenfitsch MW, Neidert N, Ng HK, Pohl U, Bale T, Quach S, Rieger D, Schüller U, Onken J, Drüschler K, Maurage CA, Regli L, Healy E, Graham M, Hortobagyi T, Paine S, Bridges L, Lausova T, Medici V, Sievers P, Schrimpf D, Wick W, Sahm F, Reifenberger G, von Deimling A, Weller M.   +38 more
europepmc   +4 more sources

G34 Integrating elements of undergraduate curriculum learning [PDF]

Archives of Disease in Childhood, 2015
Rapidly advancing practice and recognition of nursing, midwifery and medicine as a vital interrelated workforce, implies a need for a variety of curricula opportunities. This project addresses the challenge for healthcare educators to widen student engagement and participation through inter-professional education by creating learning environments ...
A Bell, D Corkin, C Moorhead, A Devlin
openaire   +1 more source

G34, Another Connection between MYCN and a Pediatric Tumor [PDF]

Cancer Discovery, 2013
Abstract Summary: Recurrent mutations in H3F3A at K27 and G34 are frequent in pediatric glioblastoma, but it is unclear how these mutations promote tumorigenesis. In this issue of Cancer Discovery, Bjerke and colleagues identify mutations at G34 in H3F3A that result in elevated expression of MYCN as a potential mechanism in gliomagenesis.
Huang, Miller, Weiss, William A
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Histone H3.3 G34 mutations promote aberrant PRC2 activity and drive tumor progression [PDF]

Proceedings of the National Academy of Sciences, 2020
Significance A high frequency of missense mutations was recently discovered at histone H3.3 glycine 34 in 92% of giant cell tumors of the bone and 17% of high-grade astrocytomas. The molecular mechanism by which G34 mutations drive these tumors remains unclear.
Siddhant U. Jain, Sima Khazaei, Dylan M. Marchione, Stefan M. Lundgren, Xiaoshi Wang, Daniel N. Weinberg, Shriya Deshmukh, Nikoleta Juretic, Chao Lu, C. David Allis, Benjamin A. Garcia, Nada Jabado, Peter W. Lewis   +12 more
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H3F3A-G34R mutant high grade neuroepithelial neoplasms with glial and dysplastic ganglion cell components

Acta Neuropathologica Communications, 2019
The recently described malignant neuro-epithelial tumors with histone H3F3A point mutations at G34 (NET-H3-G34) occur most often in cerebral hemispheres of teenagers and young adults, and have a generally adverse prognosis.
Felipe Andreiuolo, Tomo Lisner, Jozef Zlocha, Christof Kramm, Arend Koch, Brigitte Bison, Albane Gareton, Marc Zanello, Andreas Waha, Pascale Varlet, Torsten Pietsch   +10 more
doaj   +1 more source